KFU. Card publication. Ethanol and the Developing Brain: Inhibition of Neuronal Activity and Neuroapoptosis

KAZAN
FEDERAL UNIVERSITY

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ETHANOL AND THE DEVELOPING BRAIN: INHIBITION OF NEURONAL ACTIVITY AND NEUROAPOPTOSIS

Form of presentation

Russian monographs

Year of publication

2018

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Authors, employees of KFU

Khazipov Rustem Narimanovich, author

Authors, postgraduates KFU

Lotfullina Nailya Zufarovna, postgraduate kfu

Bibliographic description in the original language

Lotfullina N. Ethanol and the Developing Brain: Inhibition of Neuronal Activity and Neuroapoptosis / Lotfullina N, Khazipov R. - Neuroscientist. 2018 Apr;24(2):130-141.

Annotation

Ethanol induces massive neuroapoptosis in the developing brain. One of the main hypotheses that has been put forward to explain the deleterious actions of ethanol in the immature brain involves an inhibition of neuronal activity. Here, we review recent evidence for this hypothesis obtained in the somatosensory cortex and hippocampus of neonatal rodents. In both structures, ethanol strongly inhibits brain activity. At the doses inducing massive neuroapoptosis, ethanol completely suppresses the early activity patterns of spindle-bursts and gamma oscillations in the neocortex and the early sharp-waves in the hippocampus. The inhibitory effects of ethanol decrease with age and in adult animals, ethanol only mildly depresses neuronal firing and induces delta-wave activity. Suppression of cortical activity in neonatal animals likely involves inhibition of the myoclonic twitches, an important physiological trigger for the early activity bursts, and inhibition of the thalamocortical and intrac

Keywords

ethanol, apoptosis, electroencephalogram, fetal alcohol syndrome, GABA, NMDA

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=188808&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Khazipov Rustem Narimanovich	ru_RU
dc.contributor.author	Lotfullina Nailya Zufarovna	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Lotfullina N. Ethanol and the Developing Brain: Inhibition of Neuronal Activity and Neuroapoptosis / Lotfullina N, Khazipov R. - Neuroscientist. 2018 Apr;24(2):130-141.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=188808&p_lang=2	ru_RU
dc.description.abstract	Ethanol induces massive neuroapoptosis in the developing brain. One of the main hypotheses that has been put forward to explain the deleterious actions of ethanol in the immature brain involves an inhibition of neuronal activity. Here, we review recent evidence for this hypothesis obtained in the somatosensory cortex and hippocampus of neonatal rodents. In both structures, ethanol strongly inhibits brain activity. At the doses inducing massive neuroapoptosis, ethanol completely suppresses the early activity patterns of spindle-bursts and gamma oscillations in the neocortex and the early sharp-waves in the hippocampus. The inhibitory effects of ethanol decrease with age and in adult animals, ethanol only mildly depresses neuronal firing and induces delta-wave activity. Suppression of cortical activity in neonatal animals likely involves inhibition of the myoclonic twitches, an important physiological trigger for the early activity bursts, and inhibition of the thalamocortical and intrac	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	ethanol	ru_RU
dc.subject	apoptosis	ru_RU
dc.subject	electroencephalogram	ru_RU
dc.subject	fetal alcohol syndrome	ru_RU
dc.subject	GABA	ru_RU
dc.subject	NMDA	ru_RU
dc.title	Ethanol and the Developing Brain: Inhibition of Neuronal Activity and Neuroapoptosis	ru_RU
dc.type	Russian monographs	ru_RU