| Form of presentation | Articles in international journals and collections |
| Year of publication | 2018 |
| Язык | английский |
|
Rizvanov Albert Anatolevich, author
Tarasova Gulzada Rafailovna, author
Cherepnev Georgiy Valentinovich, author
|
| Bibliographic description in the original language |
Kalacheva N. Water-soluble polyol-methanofullerenes as mitochondria-targeted antioxidants: Mechanism of astion / Natalia Kalacheva; Gulzada Tarasova; Guzel Fazleeva;Valentina Gubskaya; Dilara Gumerova; Albert Rizvanov; Georgy Cherepnev // Bioorganic and Medicinal Chemistry Letters. - 2018. - Vol.28, Is.6. - P.1097-1100.
|
| Annotation |
The mechanism of an antioxidant action of water-soluble polyol
- methanofullerenes С60[C9H10O4((OH)4]6 and С60[C13H18O4((OH)4]6, as the
mild uncouplers of an oxidative phosphorylation and respiration is
postulated. According to this mechanism, hydroxyl group of
methanofullerenols can aссept protons with the formation of oxonium
cations in acidic environment of intermembrane space of hyperpolarized
mitochondria. Protonation of fullerene derivatives is confirmed by the
decrease in their negative zeta potential in the pH below 5.4. Heavily
protonated methanofullerenols become positively charged and diffuse into
the mitochondrial matrix. As a consequence, the proton gradient is
disrupted, which causes a decrease in mitochondrial transmembrane
potential and reduction ROS production.
|
| Keywords |
methanofullerenols, antioxidant activity, protonation, zeta
potential, hyperpolarized mitoсhondria
|
| The name of the journal |
BIOORG MED CHEM LETT
|
| Please use this ID to quote from or refer to the card |
https://repository.kpfu.ru/eng/?p_id=191431&p_lang=2 |
Full metadata record  |
| Field DC |
Value |
Language |
| dc.contributor.author |
Rizvanov Albert Anatolevich |
ru_RU |
| dc.contributor.author |
Tarasova Gulzada Rafailovna |
ru_RU |
| dc.contributor.author |
Cherepnev Georgiy Valentinovich |
ru_RU |
| dc.date.accessioned |
2018-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2018-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2018 |
ru_RU |
| dc.identifier.citation |
Kalacheva N. Water-soluble polyol-methanofullerenes as mitochondria-targeted antioxidants: Mechanism of aсtion / Natalia Kalacheva; Gulzada Tarasova; Guzel Fazleeva;Valentina Gubskaya; Dilara Gumerova; Albert Rizvanov; Georgy Cherepnev // Bioorganic and Medicinal Chemistry Letters. - 2018. - Vol.28, Is.6. - P.1097-1100.
|
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/eng/?p_id=191431&p_lang=2 |
ru_RU |
| dc.description.abstract |
BIOORG MED CHEM LETT |
ru_RU |
| dc.description.abstract |
The mechanism of an antioxidant action of water-soluble polyol
- methanofullerenes С60[C9H10O4((OH)4]6 and С60[C13H18O4((OH)4]6, as the
mild uncouplers of an oxidative phosphorylation and respiration is
postulated. According to this mechanism, hydroxyl group of
methanofullerenols can aссept protons with the formation of oxonium
cations in acidic environment of intermembrane space of hyperpolarized
mitochondria. Protonation of fullerene derivatives is confirmed by the
decrease in their negative zeta potential in the pH below 5.4. Heavily
protonated methanofullerenols become positively charged and diffuse into
the mitochondrial matrix. As a consequence, the proton gradient is
disrupted, which causes a decrease in mitochondrial transmembrane
potential and reduction ROS production.
|
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
methanofullerenols |
ru_RU |
| dc.subject |
antioxidant activity |
ru_RU |
| dc.subject |
protonation |
ru_RU |
| dc.subject |
zeta
potential |
ru_RU |
| dc.subject |
hyperpolarized mitoсhondria
|
ru_RU |
| dc.title |
Water-soluble polyol-methanofullerenes as mitochondria-targeted antioxidants: Mechanism of aсtion |
ru_RU |
| dc.type |
Articles in international journals and collections |
ru_RU |
|
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