Kazan (Volga region) Federal University, KFU
KAZAN
FEDERAL UNIVERSITY
 
WATER-SOLUBLE POLYOL-METHANOFULLERENES AS MITOCHONDRIA-TARGETED ANTIOXIDANTS: MECHANISM OF AСTION
Form of presentationArticles in international journals and collections
Year of publication2018
Языканглийский
  • Rizvanov Albert Anatolevich, author
  • Tarasova Gulzada Rafailovna, author
  • Cherepnev Georgiy Valentinovich, author
  • Bibliographic description in the original language Kalacheva N. Water-soluble polyol-methanofullerenes as mitochondria-targeted antioxidants: Mechanism of astion / Natalia Kalacheva; Gulzada Tarasova; Guzel Fazleeva;Valentina Gubskaya; Dilara Gumerova; Albert Rizvanov; Georgy Cherepnev // Bioorganic and Medicinal Chemistry Letters. - 2018. - Vol.28, Is.6. - P.1097-1100.
    Annotation The mechanism of an antioxidant action of water-soluble polyol - methanofullerenes С60[C9H10O4((OH)4]6 and С60[C13H18O4((OH)4]6, as the mild uncouplers of an oxidative phosphorylation and respiration is postulated. According to this mechanism, hydroxyl group of methanofullerenols can aссept protons with the formation of oxonium cations in acidic environment of intermembrane space of hyperpolarized mitochondria. Protonation of fullerene derivatives is confirmed by the decrease in their negative zeta potential in the pH below 5.4. Heavily protonated methanofullerenols become positively charged and diffuse into the mitochondrial matrix. As a consequence, the proton gradient is disrupted, which causes a decrease in mitochondrial transmembrane potential and reduction ROS production.
    Keywords methanofullerenols, antioxidant activity, protonation, zeta potential, hyperpolarized mitoсhondria
    The name of the journal BIOORG MED CHEM LETT
    Please use this ID to quote from or refer to the card https://repository.kpfu.ru/eng/?p_id=191431&p_lang=2

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