KFU. Card publication. Conformational Variability of Cyclosporin C Dissolved in Dimethylformamide

KAZAN
FEDERAL UNIVERSITY

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CONFORMATIONAL VARIABILITY OF CYCLOSPORIN C DISSOLVED IN DIMETHYLFORMAMIDE

Form of presentation

Articles in international journals and collections

Year of publication

2019

Язык

английский

Authors, employees of KFU

Efimov Sergey Vladimirovich, author

Zgadzay Yuriy Olegovich, author

Klochkov Vladimir Vasilevich, author

Authors, students KFU

Darvish Shaza , author

Bibliographic description in the original language

Conformational Variability of Cyclosporin C Dissolved in Dimethylformamide / S.V. Efimov, Yu.O. Zgadzay, S. Darwish, V.V. Klochkov // BioNanoScience. - 2019. - Vol. 9, Is. 3. - P. 620-624.

Annotation

This paper presents characterization of conformational equilibrium of cyclosporin C dissolved in dimethylformamide. High-resolution NMR spectra recorded at 700 MHz allowed distinguishing most of observed amide proton signals. Existence of several intramolecular hydrogen bonds over the whole set of conformers was supposed; in most cases, however, these bonds are disrupted. Kinetics of a conformational transition is evaluated. Obtained results are in agreement with what is known about cyclosporin A, but can give new information on the role of additional H-bond donors (there are six of them in CsC vs. five in CsA) in the observed chain flexibility.

Keywords

dynamic NMR, cyclosporin C, chemical exchange, hydrogen bond

The name of the journal

BioNanoScience

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066106117&doi=10.1007%2fs12668-019-00641-z&partnerID=40&md5=cb85cba8236adc0f3df8a093f6c89161

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=204648&p_lang=2

Resource files

File name	Size (MB)	Format
BNSC_uncorrected_proof.pdf	0,54	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Efimov Sergey Vladimirovich	ru_RU
dc.contributor.author	Zgadzay Yuriy Olegovich	ru_RU
dc.contributor.author	Klochkov Vladimir Vasilevich	ru_RU
dc.contributor.author	Darvish Shaza	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Conformational Variability of Cyclosporin C Dissolved in Dimethylformamide / S.V. Efimov, Yu.O. Zgadzay, S. Darwish, V.V. Klochkov // BioNanoScience. - 2019. - Vol. 9, Is. 3. - P. 620-624.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=204648&p_lang=2	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	This paper presents characterization of conformational equilibrium of cyclosporin C dissolved in dimethylformamide. High-resolution NMR spectra recorded at 700 MHz allowed distinguishing most of observed amide proton signals. Existence of several intramolecular hydrogen bonds over the whole set of conformers was supposed; in most cases, however, these bonds are disrupted. Kinetics of a conformational transition is evaluated. Obtained results are in agreement with what is known about cyclosporin A, but can give new information on the role of additional H-bond donors (there are six of them in CsC vs. five in CsA) in the observed chain flexibility.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	dynamic NMR	ru_RU
dc.subject	cyclosporin C	ru_RU
dc.subject	chemical exchange	ru_RU
dc.subject	hydrogen bond	ru_RU
dc.title	Conformational Variability of Cyclosporin C Dissolved in Dimethylformamide	ru_RU
dc.type	Articles in international journals and collections	ru_RU