KFU. Card publication. A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy

KAZAN
FEDERAL UNIVERSITY

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A POTENTIAL ROLE FOR T-TYPE CALCIUM CHANNELS IN HOMOCYSTEINEMIA-INDUCED PERIPHERAL NEUROPATHY

Form of presentation

Articles in international journals and collections

Year of publication

2019

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Authors, employees of KFU

Gerasimova Elena Vyacheslavovna, author

Zakirova Gulshat Foatovna, author

Sitdikova Guzel Faritovna, author

Bibliographic description in the original language

Gaifullina AS, Lazniewska J, Gerasimova EV, Burkhanova GF, Rzhepetskyy Y, Tomin A, Rivas-Ramirez P, Huang J, Cmarko L, Zamponi GW ,Sitdikova GF, Weiss N. A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy. Pain. 2019, 160(12):2798-2810. doi: 10.1097/j.pain.0000000000001669

Annotation

Pain

Keywords

homocysteinemia, T-type calcium channels

The name of the journal

Pain

URL

https://www.ncbi.nlm.nih.gov/pubmed/31365467

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=206686&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gerasimova Elena Vyacheslavovna	ru_RU
dc.contributor.author	Zakirova Gulshat Foatovna	ru_RU
dc.contributor.author	Sitdikova Guzel Faritovna	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Gaifullina AS, Lazniewska J, Gerasimova EV, Burkhanova GF, Rzhepetskyy Y, Tomin A, Rivas-Ramirez P, Huang J, Cmarko L, Zamponi GW ,Sitdikova GF, Weiss N. A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy. Pain. 2019, 160(12):2798-2810. doi: 10.1097/j.pain.0000000000001669	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=206686&p_lang=2	ru_RU
dc.description.abstract	Pain	ru_RU
dc.description.abstract	Homocysteinemia is a metabolic condition characterized by abnormally high level of homocysteine in the blood and is considered to be a risk factor for peripheral neuropathy. However, the cellular mechanisms underlying toxic effects of homocysteine on the processing of peripheral nociception have not yet been investigated comprehensively. Here, using a rodent model of experimental homocysteinemia, we report the causal association between homocysteine and the development of mechanical allodynia. Homocysteinemia-induced mechanical allodynia was reversed upon pharmacological inhibition of T-type calcium channels. In addition, our in vitro studies indicate that homocysteine enhances recombinant T-type calcium currents by promoting the recycling of Cav3.2 channels back to the plasma membrane via a PKC-dependent signaling pathway that requires the direct phosphorylation of Cav3.2 at specific loci. Altogether, these results reveal an unrecognized signaling pathway that modulates the expression of T-type calcium channels, and may potentially contribute to the development of peripheral neuropathy associated with homocysteinemia.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	homocysteinemia	ru_RU
dc.subject	T-type calcium channels	ru_RU
dc.title	A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy	ru_RU
dc.type	Articles in international journals and collections	ru_RU