KFU. Card publication. Different Approaches to Modulation of Microglia Phenotypes After Spinal Cord Injury

KAZAN
FEDERAL UNIVERSITY

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DIFFERENT APPROACHES TO MODULATION OF MICROGLIA PHENOTYPES AFTER SPINAL CORD INJURY

Form of presentation

Articles in international journals and collections

Year of publication

2019

Authors, employees of KFU

Akhmetzyanova Elvira Ruslanovna, author

Kletenkov Konstantin Sergeevich, author

Mukhamedshina Yana Olegovna, author

Rizvanov Albert Anatolevich, author

Authors, postgraduates KFU

Akhmetzyanova Elvira Ruslanovna, postgraduate kfu

Bibliographic description in the original language

Akhmetzyanova, E.R., Kletenkov, K.S., Mukhamedshina, Y.O. and Rizvanov, A., 2019. Different approaches to modulation of microglia phenotypes after spinal cord injury. Frontiers in Systems Neuroscience, 13, p.37.

Annotation

Frontiers in system neuroscience

Keywords

microglia, phenotypes, modulation, spinal cord injury, neuroregeneration.

Place of publication

Lausanne

The name of the journal

Frontiers in system neuroscience

Publishing house

Frontiers

URL

https://doi.org/10.3389/fnsys.2019.00037

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=210579&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Akhmetzyanova Elvira Ruslanovna	ru_RU
dc.contributor.author	Kletenkov Konstantin Sergeevich	ru_RU
dc.contributor.author	Mukhamedshina Yana Olegovna	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Akhmetzyanova Elvira Ruslanovna	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Akhmetzyanova, E.R., Kletenkov, K.S., Mukhamedshina, Y.O. and Rizvanov, A., 2019. Different approaches to modulation of microglia phenotypes after spinal cord injury. Frontiers in Systems Neuroscience, 13, p.37.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=210579&p_lang=2	ru_RU
dc.description.abstract	Frontiers in system neuroscience	ru_RU
dc.description.abstract	Microglial cells, which are highly plastic, immediately respond to any change in the microenvironment by becoming activated and shifting the phenotype toward neurotoxicity or neuroprotection. The polarization of microglia/macrophages after spinal cord injury (SCI) seems to be a dynamic process and can change depending on the microenvironment, stage, course, and severity of the posttraumatic process. Effective methods to modulate microglia toward a neuroprotective phenotype in order to stimulate neuroregeneration are actively sought for. In this context, available approaches that can selectively impact the polarization of microglia/macrophages regulate synthesis of trophic factors and cytokines/chemokines in them, and their phagocytic function and effects on the course and outcome of SCI are discussed in this review.	ru_RU
dc.language.iso	ru	ru_RU
dc.publisher	Frontiers	ru_RU
dc.subject	microglia	ru_RU
dc.subject	phenotypes	ru_RU
dc.subject	modulation	ru_RU
dc.subject	spinal cord injury	ru_RU
dc.subject	neuroregeneration.	ru_RU
dc.title	Different Approaches to Modulation of Microglia Phenotypes After Spinal Cord Injury	ru_RU
dc.type	Articles in international journals and collections	ru_RU