KFU. Card publication. Detection of Macro-throtropin in patients with Hashimotos Thyroiditis and subclinical hypothyroidism

KAZAN
FEDERAL UNIVERSITY

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DETECTION OF MACRO-THROTROPIN IN PATIENTS WITH HASHIMOTOS THYROIDITIS AND SUBCLINICAL HYPOTHYROIDISM

Form of presentation

Articles in international journals and collections

Year of publication

2019

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Authors, employees of KFU

Abramova Zinaida Ivanovna, author

Biktagirova Elnara Mauletovna, author

Nevzorova Tatyana Aleksandrovna, author

Authors, postgraduates KFU

Abramov Sergey Nikolaevich, postgraduate kfu

Semakov Grigoriy Pavlovich, postgraduate kfu

Bibliographic description in the original language

Zolotoverkchova Z. I. Detection of Macro-thyrotropin in patients with Hashimotos Thyroiditis and subclinical hypothyroidism /Z. I. Zolotoverkchova, E. M. Biktagirova, G. P. Semakov, S.N. Abramov, T. A. Nevzorova, G. R. Vagapova, Z. I. Abramova //Human Gene Therapy.-2019.-V.30.- No. 11.-A120-120

Annotation

The level of thyroid stimulating hormone (TSH) is one of the diagnostic markers of thyroid function. In subclinical hypothyroidism, the concentration of TSH in the blood serum increases, while the level of thyroid hormones stay the same. The reason for this observation is the macroTSH phenomenon, in which the macro isoforms of TSH (a complex of TSH with IgG) are present in the blood. Blood serum collected from 50 patients (30 patients with subclinical hypothyroidism, 10 - with manifest hypothyroidism, 10 - control group) was screened for the presence of macroTSH by polyethylene glycol (PEG)-precipitation and analyzed using gel filtration chromatography. As a result of the screening, 56–98% of 50–100% serum TSH was identified as true macroTSH. In patients with subclinical hypothyroidism with the TSH level of more than 10 μIU/ml, a trend towards an increase in the level of macroTSH has been shown. It is known that elevated levels of antibodies to thyroperoxidase (TPO) can lead to the generation of macroTSH. Thus, we identified that the amount of macroTSH complex in patients with subclinical hypothyroidism, in whom the level of antibodies to TPO is >500 U/L, is significantly higher compared with patients with manifest hypothyroidism. Patients with the TSH level of more than 10 μIU/ml are candidates for screening for the presence of the macroTSH complex. This research was supported by the subsidy of the Russian Government to support the Program of the competitive growth of Kazan Federal University.

Keywords

thyroid stimulating hormone, Macro-thyrotropin, hashimotos thyroiditis

The name of the journal

HUMAN GENE THERAPY

URL

https://www.liebertpub.com/doi/10.1089/hum.2019.29095.abstracts

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=214949&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abramova Zinaida Ivanovna	ru_RU
dc.contributor.author	Biktagirova Elnara Mauletovna	ru_RU
dc.contributor.author	Nevzorova Tatyana Aleksandrovna	ru_RU
dc.contributor.author	Abramov Sergey Nikolaevich	ru_RU
dc.contributor.author	Semakov Grigoriy Pavlovich	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Zolotoverkchova Z. I. Detection of Macro-thyrotropin in patients with Hashimotos Thyroiditis and subclinical hypothyroidism /Z. I. Zolotoverkchova, E. M. Biktagirova, G. P. Semakov, S.N. Abramov, T. A. Nevzorova, G. R. Vagapova, Z. I. Abramova //Human Gene Therapy.-2019.-V.30.- No. 11.-A120-120	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=214949&p_lang=2	ru_RU
dc.description.abstract	HUMAN GENE THERAPY	ru_RU
dc.description.abstract	The level of thyroid stimulating hormone (TSH) is one of the diagnostic markers of thyroid function. In subclinical hypothyroidism, the concentration of TSH in the blood serum increases, while the level of thyroid hormones stay the same. The reason for this observation is the macroTSH phenomenon, in which the macro isoforms of TSH (a complex of TSH with IgG) are present in the blood. Blood serum collected from 50 patients (30 patients with subclinical hypothyroidism, 10 - with manifest hypothyroidism, 10 - control group) was screened for the presence of macroTSH by polyethylene glycol (PEG)-precipitation and analyzed using gel filtration chromatography. As a result of the screening, 56–98% of 50–100% serum TSH was identified as true macroTSH. In patients with subclinical hypothyroidism with the TSH level of more than 10 μIU/ml, a trend towards an increase in the level of macroTSH has been shown. It is known that elevated levels of antibodies to thyroperoxidase (TPO) can lead to the generation of macroTSH. Thus, we identified that the amount of macroTSH complex in patients with subclinical hypothyroidism, in whom the level of antibodies to TPO is >500 U/L, is significantly higher compared with patients with manifest hypothyroidism. Patients with the TSH level of more than 10 μIU/ml are candidates for screening for the presence of the macroTSH complex. This research was supported by the subsidy of the Russian Government to support the Program of the competitive growth of Kazan Federal University.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	thyroid stimulating hormone	ru_RU
dc.subject	Macro-thyrotropin	ru_RU
dc.subject	hashimotos thyroiditis	ru_RU
dc.title	Detection of Macro-throtropin in patients with Hashimotos Thyroiditis and subclinical hypothyroidism	ru_RU
dc.type	Articles in international journals and collections	ru_RU