KFU. Card publication. Определение феномена макротиротропинемии у пациентов с аутоиммунным тиреоидитом и субклиническим гипотиреозом

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

ОПРЕДЕЛЕНИЕ ФЕНОМЕНА МАКРОТИРОТРОПИНЕМИИ У ПАЦИЕНТОВ С АУТОИММУННЫМ ТИРЕОИДИТОМ И СУБКЛИНИЧЕСКИМ ГИПОТИРЕОЗОМ

Form of presentation

Articles in Russian journals and collections

Year of publication

2019

Язык

русский

Authors, employees of KFU

Abramova Zinaida Ivanovna, author

Akberova Natalya Ivanovna, author

Andrianova Izabella Aleksandrovna, author

Biktagirova Elnara Mauletovna, author

Nevzorova Tatyana Aleksandrovna, author

Authors, postgraduates KFU

Semakov Grigoriy Pavlovich, postgraduate kfu

Authors, students KFU

Evtyugina Natalya Gennadevna, author

Zolotoverkhova Svetlana Aleksandrovna, author

Bibliographic description in the original language

Biktagirova E.M. Opredelenie fenomena makrotirotropinemii u pacientov s autoimmunnym tireoiditom i subklinicheskim gipotireozom / E. M. Biktagirova, G. P. Semakov, N. I. Zolotoverkhova, T. A. Nevzorova, I. A. Andrianova, N. G. Evtyugina, N. I. Akberova, A. N. Khisamutdinov, G. R. Vagapova, Z. I. Abramova // Medicinskaya immunologiya. – 2019. – T. – 21, № - 6.-S. - 1063-1072 (IF 0.240 SJR 0.120 RINC 0.706)

Annotation

The level of thyroid stimulating hormone is one of the diagnostic indicators of thyroid function. In subclinical hypothyroidism, its concentration in the blood serum increases, while the level of thyroid hormones remains normal. One of the reasons for this is the phenomenon of macrotyrotropinemia, in which the macro isoforms of thyrotropin (a complex of thyrotropic hormone with immunoglobulin) are present in the blood. It is assumed that the biological activity of macrotyrotropin is low, and may accumulate in the circulation, causing a falsely elevated level of thyroid-stimulating hormone in serum. The aim of this study is to identify the nature and prevalence of the macrothyrotropinemia phenomenon among patients with subclinical hypothyroidism in presence of autoimmune thyroiditis and a group of healthy donors. Materials and methods: Fifty serum samples of venous blood served as the material for the study: 30 patients with subclinical hypothyroidism in presence of autoimmune thyroiditis; 10, with manifesting hypothyroidism, 10 conditionally healthy donors without thyroid gland pathology (control group). The group was derived from results of the clinical laboratory at the Clinical Hospital at the Kazan station railway. Patients' blood serum was screened for the presence of macrotrorotropin by polyethylene glycol precipitation method, followed by analysis by gel filtration chromatography. Results of this study were as follows: screening of blood sera was performed by gel filtration and affinity chromatography. Polyethylene glycol was shown to precipitate 50 to 100% serum thyrotropin, of which true macrotrothropin makes 56-98%. In the patients with subclinical hypothyroidism with a thyroid-stimulating hormone level of more than 10 ?IU/ml, a trend towards an increase in the level of macrothyrotrophinaemia has been shown. The content of macrotyrotropin complex in patients with subclinical hypothyroidism, in whom the level of antibodies to thyroperoxidase is > 500 U/L, is significantly higher if compared to the patients with manifesting hypothyroidism. Elevated levels of antibodies to thyroperoxidase can lead to the generation of macrotyropin. Our findings have shown that the phenomenon of macrothyrotropinemia is quite common in patients with subclinical and manifesting hypothyroidism with Hashimoto thyroiditis (53.3%) and in control group (25%). Macrotyrotropin complex probably consists of thyrotropin and IgG. Patients with a thyroid-stimulating hormone level of > 10 ?IU/ml are candidates for screening for the presence of the macrotyrotropin complex. The activity of the autoimmune process may correlate with the phenomenon of macrothyrotropinemia. The results can be used to develop an additional tool when choosing therapy in clinical practice.

Keywords

макротиротропинемия, аутоиммунный тиреоидит, субклинический гипотиреоз, гель-фильтрационная хроматография, аффинная хроматография

The name of the journal

Медицинская иммунология

URL

https://www.mimmun.ru/mimmun/article/view/1777

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=215215&p_lang=2

Resource files

File name	Size (MB)	Format
F_FENOMEN_MAKROTIROTROPINEMII.pdf	0,42	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abramova Zinaida Ivanovna	ru_RU
dc.contributor.author	Akberova Natalya Ivanovna	ru_RU
dc.contributor.author	Andrianova Izabella Aleksandrovna	ru_RU
dc.contributor.author	Biktagirova Elnara Mauletovna	ru_RU
dc.contributor.author	Nevzorova Tatyana Aleksandrovna	ru_RU
dc.contributor.author	Evtyugina Natalya Gennadevna	ru_RU
dc.contributor.author	Zolotoverkhova Svetlana Aleksandrovna	ru_RU
dc.contributor.author	Semakov Grigoriy Pavlovich	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Биктагирова Э.М. Определение феномена макротиротропинемии у пациентов с аутоиммунным тиреоидитом и субклиническим гипотиреозом / Э. М. Биктагирова, Г. П. Семаков, Н. И. Золотоверхова, Т. А. Невзорова, И. А. Андрианова, Н. Г. Евтюгина, Н. И. Акберова, А. Н. Хисамутдинов, Г. Р. Вагапова, З. И. Абрамова // Медицинская иммунология. – 2019. – Т. – 21, № - 6.-С. - 1063-1072 (IF 0.240 SJR 0.120 РИНЦ 0.706)	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=215215&p_lang=2	ru_RU
dc.description.abstract	Медицинская иммунология	ru_RU
dc.description.abstract	The level of thyroid stimulating hormone is one of the diagnostic indicators of thyroid function. In subclinical hypothyroidism, its concentration in the blood serum increases, while the level of thyroid hormones remains normal. One of the reasons for this is the phenomenon of macrotyrotropinemia, in which the macro isoforms of thyrotropin (a complex of thyrotropic hormone with immunoglobulin) are present in the blood. It is assumed that the biological activity of macrotyrotropin is low, and may accumulate in the circulation, causing a falsely elevated level of thyroid-stimulating hormone in serum. The aim of this study is to identify the nature and prevalence of the macrothyrotropinemia phenomenon among patients with subclinical hypothyroidism in presence of autoimmune thyroiditis and a group of healthy donors. Materials and methods: Fifty serum samples of venous blood served as the material for the study: 30 patients with subclinical hypothyroidism in presence of autoimmune thyroiditis; 10, with manifesting hypothyroidism, 10 conditionally healthy donors without thyroid gland pathology (control group). The group was derived from results of the clinical laboratory at the Clinical Hospital at the Kazan station railway. Patients' blood serum was screened for the presence of macrotrorotropin by polyethylene glycol precipitation method, followed by analysis by gel filtration chromatography. Results of this study were as follows: screening of blood sera was performed by gel filtration and affinity chromatography. Polyethylene glycol was shown to precipitate 50 to 100% serum thyrotropin, of which true macrotrothropin makes 56-98%. In the patients with subclinical hypothyroidism with a thyroid-stimulating hormone level of more than 10 ?IU/ml, a trend towards an increase in the level of macrothyrotrophinaemia has been shown. The content of macrotyrotropin complex in patients with subclinical hypothyroidism, in whom the level of antibodies to thyroperoxidase is > 500 U/L, is significantly higher if compared to the patients with manifesting hypothyroidism. Elevated levels of antibodies to thyroperoxidase can lead to the generation of macrotyropin. Our findings have shown that the phenomenon of macrothyrotropinemia is quite common in patients with subclinical and manifesting hypothyroidism with Hashimoto thyroiditis (53.3%) and in control group (25%). Macrotyrotropin complex probably consists of thyrotropin and IgG. Patients with a thyroid-stimulating hormone level of > 10 ?IU/ml are candidates for screening for the presence of the macrotyrotropin complex. The activity of the autoimmune process may correlate with the phenomenon of macrothyrotropinemia. The results can be used to develop an additional tool when choosing therapy in clinical practice.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	макротиротропинемия	ru_RU
dc.subject	аутоиммунный тиреоидит	ru_RU
dc.subject	субклинический гипотиреоз	ru_RU
dc.subject	гель-фильтрационная хроматография	ru_RU
dc.subject	аффинная хроматография	ru_RU
dc.title	Определение феномена макротиротропинемии у пациентов с аутоиммунным тиреоидитом и субклиническим гипотиреозом	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU