KFU. Card publication. Synthesis and biological evaluation of new isatin-based QACs with high antimicrobial potency.

KAZAN
FEDERAL UNIVERSITY

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SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW ISATIN-BASED QACS WITH HIGH ANTIMICROBIAL POTENCY.

Form of presentation

Articles in international journals and collections

Year of publication

2019

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Authors, employees of KFU

Bogdanov Andrey Vladimirovich, author

Mironov Vladimir Fedorovich, author

Bibliographic description in the original language

A.V.Bogdanov, I.F.Zaripova, A.D.Voloshina, A.S.Sapunova, N.V.Kulik, S.V. Bukharov, J.K.Voronina, A.E.Vandyukov, V.F.Mironov. Synthesis and biological evaluation of new isatin-based QACs with high antimicrobial potency. // Chemistry Select. 2019. Vol. 4. No 20. P. 6162-6166. Doi 10.1002/slct.201901708.

Annotation

A simple and easy condensation reaction of aryl- or Nsubstituted isatins with Girard's reagents P and T was found to be useful in obtaining of water-soluble isatin-based quaternary ammonium compounds (QACs) bearing pyridinium or trimethylammonium moiety with high yields. Their antimicrobial activity was evaluated. Selective activity against Gram-positive bacteria (S. aureus 209p and B. cereus 8035) and yeast-like fungus Candida albicans 855–653 was shown. The influence of the substituent's nature as in the aromatic fragment as at position 1 on the activity was established. The most active are the pyridinium salts containing sterically hindered phenolic fragment at the position 1 of the heterocycle. The structures of all novel compounds were fully characterized using IR and NMR spectroscopies as well as XRD analysis.

Keywords

isatin, quaternary ammonium compounds, antimicrobial activity, XRD analysis

The name of the journal

CHEMISTRYSELECT

URL

https://onlinelibrary.wiley.com/doi/full/10.1002/slct.201901708

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=215420&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Bogdanov Andrey Vladimirovich	ru_RU
dc.contributor.author	Mironov Vladimir Fedorovich	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	A.V.Bogdanov, I.F.Zaripova, A.D.Voloshina, A.S.Sapunova, N.V.Kulik, S.V. Bukharov, J.K.Voronina, A.E.Vandyukov, V.F.Mironov. Synthesis and biological evaluation of new isatin-based QACs with high antimicrobial potency. // Chemistry Select. 2019. Vol. 4. No 20. P. 6162-6166. Doi 10.1002/slct.201901708.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=215420&p_lang=2	ru_RU
dc.description.abstract	CHEMISTRYSELECT	ru_RU
dc.description.abstract	A simple and easy condensation reaction of aryl- or Nsubstituted isatins with Girard's reagents P and T was found to be useful in obtaining of water-soluble isatin-based quaternary ammonium compounds (QACs) bearing pyridinium or trimethylammonium moiety with high yields. Their antimicrobial activity was evaluated. Selective activity against Gram-positive bacteria (S. aureus 209p and B. cereus 8035) and yeast-like fungus Candida albicans 855–653 was shown. The influence of the substituent's nature as in the aromatic fragment as at position 1 on the activity was established. The most active are the pyridinium salts containing sterically hindered phenolic fragment at the position 1 of the heterocycle. The structures of all novel compounds were fully characterized using IR and NMR spectroscopies as well as XRD analysis.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	isatin	ru_RU
dc.subject	quaternary ammonium compounds	ru_RU
dc.subject	antimicrobial activity	ru_RU
dc.subject	XRD analysis	ru_RU
dc.title	Synthesis and biological evaluation of new isatin-based QACs with high antimicrobial potency.	ru_RU
dc.type	Articles in international journals and collections	ru_RU