KFU. Card publication. The Reaction of the 3-Week-Old Rats Heart to Α2-Adrenoceptors Stimulation

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THE REACTION OF THE 3-WEEK-OLD RATS HEART TO Α2-ADRENOCEPTORS STIMULATION

Form of presentation

Articles in Russian journals and collections

Year of publication

2019

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Authors, employees of KFU

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Kupcova Anna Mikhaylovna, author

Faskhutdinov Lenar Ilsurovich, author

Bibliographic description in the original language

Zefirov T.L. The Reaction of the 3-Week-Old Rats Heart to Α2-Adrenoceptors Stimulation / T.L. Zefirov, A.M. Kuptsova, L.I. Khisamieva, L.I. Faskhutdinov, N.I. Ziyatdinova // Biosc.Biotech.Res.Comm Special Issue. - Vol. 12. - �5. - 2019. - P. 248-253.

Annotation

Heart development is an accurate and complex process controlled by the nervous and humoral regulation of the body. Modern literature presents a sufficient number of results on the formation, development, and growth of sympathetic and parasympathetic nerve fibers in the heart. Adrenergic regulation of cardiac activity is realized through many subtypes of adrenergic receptors (AR). In the heart of mammals and humans, α2-adrenergic receptors (α2-AR) of presynaptic membranes take part in the modulation of the release of norepinephrine, inhibiting the release of acetylcholine from cholinergic synapses, stimulating platelet aggregation, and narrowing the vessels of certain organs. In the central nervous system, activation of postsynaptic α2-adrenergic receptors causes a protective reflex, a sedative effect, and lowers blood pressure. Non-selective stimulation of α2-AR in isolated hearts of guinea pigs leads to a drop in pressure developed by the left ventricle during sympathetic stimulation. The objective of the research was to identify the effect of stimulation of α2-AR in the heart of rats during the onset of the formation of sympathetic innervation of the heart. Ex vivo experiments were performed on Langendorff-isolated hearts. In vivo experiments were performed on a holistic organism. Studies on the whole organism showed that intravenous administration of clonidine hydrochloride leads to bradycardia in 3-week-old rats. Application of the α2-adrenergic receptor antagonist - clonidine hydrochloride in experiments on a Langendorff-isolated heart of 3-week-old rats also causes a decrease in heart rate. The severity of this effect has a concentration dependence. Clonidine had a multidirectional effect on the blood supply to the heart. An agonist at a concentration of 10–9 M and 10–6 M reduces, and at a concentration of 10–8 M increases the coronary flow. Clonidine hydrochloride at a concentration of 10-7 M causes the multidirectional effects of heart circulation of 3-week-old rats. The multidirectional effect of stimulation of α2-adrenergic receptors on CF can be associated with different localization (pre- and postsynaptic) of different subtypes of α2-AR, as well as the ability of these adrenoreceptors to bind to different G-proteins.

Keywords

Alpha2-Adrenergic Receptors, Isolated Heart, Heart Rate, Coronary Flow, Sympathetic Cardiac Innervation, Rat

The name of the journal

Bioscience Biotechnology Research Communications

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=215556&p_lang=2

Resource files

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Full metadata record

Field DC	Value	Language
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Kupcova Anna Mikhaylovna	ru_RU
dc.contributor.author	Faskhutdinov Lenar Ilsurovich	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Zefirov T.L. The Reaction of the 3-Week-Old Rats Heart to Α2-Adrenoceptors Stimulation / T.L. Zefirov, A.M. Kuptsova, L.I. Khisamieva, L.I. Faskhutdinov, N.I. Ziyatdinova // Biosc.Biotech.Res.Comm Special Issue. - Vol. 12. - �5. - 2019. - P. 248-253.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=215556&p_lang=2	ru_RU
dc.description.abstract	Bioscience Biotechnology Research Communications	ru_RU
dc.description.abstract	Heart development is an accurate and complex process controlled by the nervous and humoral regulation of the body. Modern literature presents a sufficient number of results on the formation, development, and growth of sympathetic and parasympathetic nerve fibers in the heart. Adrenergic regulation of cardiac activity is realized through many subtypes of adrenergic receptors (AR). In the heart of mammals and humans, α2-adrenergic receptors (α2-AR) of presynaptic membranes take part in the modulation of the release of norepinephrine, inhibiting the release of acetylcholine from cholinergic synapses, stimulating platelet aggregation, and narrowing the vessels of certain organs. In the central nervous system, activation of postsynaptic α2-adrenergic receptors causes a protective reflex, a sedative effect, and lowers blood pressure. Non-selective stimulation of α2-AR in isolated hearts of guinea pigs leads to a drop in pressure developed by the left ventricle during sympathetic stimulation. The objective of the research was to identify the effect of stimulation of α2-AR in the heart of rats during the onset of the formation of sympathetic innervation of the heart. Ex vivo experiments were performed on Langendorff-isolated hearts. In vivo experiments were performed on a holistic organism. Studies on the whole organism showed that intravenous administration of clonidine hydrochloride leads to bradycardia in 3-week-old rats. Application of the α2-adrenergic receptor antagonist - clonidine hydrochloride in experiments on a Langendorff-isolated heart of 3-week-old rats also causes a decrease in heart rate. The severity of this effect has a concentration dependence. Clonidine had a multidirectional effect on the blood supply to the heart. An agonist at a concentration of 10–9 M and 10–6 M reduces, and at a concentration of 10–8 M increases the coronary flow. Clonidine hydrochloride at a concentration of 10-7 M causes the multidirectional effects of heart circulation of 3-week-old rats. The multidirectional effect of stimulation of α2-adrenergic receptors on CF can be associated with different localization (pre- and postsynaptic) of different subtypes of α2-AR, as well as the ability of these adrenoreceptors to bind to different G-proteins.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Alpha2-Adrenergic Receptors	ru_RU
dc.subject	Isolated Heart	ru_RU
dc.subject	Heart Rate	ru_RU
dc.subject	Coronary Flow	ru_RU
dc.subject	Sympathetic Cardiac Innervation	ru_RU
dc.subject	Rat	ru_RU
dc.title	The Reaction of the 3-Week-Old Rats Heart to Α2-Adrenoceptors Stimulation	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU