KFU. Card publication. Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene

KAZAN
FEDERAL UNIVERSITY

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SYNTHETIC MODULATOR OF CHYMOTRYPSIN ACTIVITY BASED ON P-TERT-BUTYLTHIACALIX[4]ARENE

Form of presentation

Articles in Russian journals and collections

Year of publication

2019

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Authors, employees of KFU

Zuev Yuriy Fedorovich, author

Mostovaya Olga Aleksandrovna, author

Padnya Pavel Leonidovich, author

Stoykov Ivan Ivanovich, author

Bibliographic description in the original language

Mostovaya O. A. Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene / O. A. Mostovaya, Yu. A. Valiullina, Ch. T. Chan, O. S. Potrekeeva, P. L. Padnya, Yu. F. Zuev, I. I. Stoikov // Mendeleev Commun. - 2019. - 29. - P. 520–522.

Annotation

A p-tert-butylthiacalix[4]arene derivative containing tryptophan moieties on the lower rim was synthesized and proposed as a chymotrypsin inhibitor. Its ability to competitively inhibit the enzyme was revealed by kinetic methods. A mechanism of the inhibitory action has been established, which consists in the binding of macrocycle tryptophan moieties to the enzyme active site, resulting in its blocking.

Keywords

��, ��, �� , thiacalix[4]arenes, tryptophan, enzymatic activity

The name of the journal

MENDELEEV COMMUN

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=216350&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zuev Yuriy Fedorovich	ru_RU
dc.contributor.author	Mostovaya Olga Aleksandrovna	ru_RU
dc.contributor.author	Padnya Pavel Leonidovich	ru_RU
dc.contributor.author	Stoykov Ivan Ivanovich	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Mostovaya O. A. Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene / O. A. Mostovaya, Yu. A. Valiullina, Ch. T. Chan, O. S. Potrekeeva, P. L. Padnya, Yu. F. Zuev, I. I. Stoikov // Mendeleev Commun. - 2019. - 29. - P. 520–522.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=216350&p_lang=2	ru_RU
dc.description.abstract	MENDELEEV COMMUN	ru_RU
dc.description.abstract	A p-tert-butylthiacalix[4]arene derivative containing tryptophan moieties on the lower rim was synthesized and proposed as a chymotrypsin inhibitor. Its ability to competitively inhibit the enzyme was revealed by kinetic methods. A mechanism of the inhibitory action has been established, which consists in the binding of macrocycle tryptophan moieties to the enzyme active site, resulting in its blocking.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	��	ru_RU
dc.subject	��	ru_RU
dc.subject	��	ru_RU
dc.subject	thiacalix[4]arenes	ru_RU
dc.subject	tryptophan	ru_RU
dc.subject	enzymatic activity	ru_RU
dc.title	Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU