KFU. Card publication. An improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion

KAZAN
FEDERAL UNIVERSITY

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- 中文
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AN IMPROVED METHOD OF DELIVERING A SCLEROSING AGENT FOR THE TREATMENT OF MALIGNANT PLEURAL EFFUSION

Form of presentation

Articles in international journals and collections

Year of publication

2019

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Authors, employees of KFU

Bumber Yanis Alekseevich, author

Deneka Aleksandr Yaroslavovich, author

Other authors

Beck Tim , author

Chai Louis , author

Golemis Erica , author

Johal Priya , author

Kanach Colin , author

Laub Glenn , author

Bibliographic description in the original language

Beck T.N. An improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion / T.N. Beck, A.Y. Deneka, L. Chai, C. Kanach, P. Johal, N.J. Alvarez, Y. Boumber, E.A. Golemis, G.W. Laub // BMC Cancer. – 2019.-V.19, N.1.-A: 614. doi: 10.1186/s12885-019-5777-z.

Annotation

BMC Cancer

Keywords

Lung cancer, Metastatic cancer, Talc, Pleurodesis, Malignant pleural effusion, Mouse model, Sclerosing agent, Thermosensitive hydrogel

The name of the journal

BMC Cancer

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=220755&p_lang=2

Resource files

File name	Size (MB)	Format
F_11._Beck_et_al_2019_BMC_Cancer.pdf	5,47	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Bumber Yanis Alekseevich	ru_RU
dc.contributor.author	Deneka Aleksandr Yaroslavovich	ru_RU
dc.contributor.author	Beck Tim	ru_RU
dc.contributor.author	Chai Louis	ru_RU
dc.contributor.author	Golemis Erica	ru_RU
dc.contributor.author	Johal Priya	ru_RU
dc.contributor.author	Kanach Colin	ru_RU
dc.contributor.author	Laub Glenn	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Beck T.N. An improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion / T.N. Beck, A.Y. Deneka, L. Chai, C. Kanach, P. Johal, N.J. Alvarez, Y. Boumber, E.A. Golemis, G.W. Laub // BMC Cancer. – 2019.-V.19, N.1.-A: 614. doi: 10.1186/s12885-019-5777-z.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=220755&p_lang=2	ru_RU
dc.description.abstract	BMC Cancer	ru_RU
dc.description.abstract	Background: Malignant pleural effusion (MPE) is a devastating sequela associated with cancer. Talc pleurodesis is a common treatment strategy for MPE but has been estimated to be unsuccessful in up to 20–50% of patients. Clinical failure of talc pleurodesis is thought to be due to poor dispersion. This monograph reports the development of a foam delivery system designed to more effectively coat the pleural cavity. Methods: C57BL/6 mice were injected with Lewis lung carcinoma (LL/2) cells intrapleurally to induce MPE. The mice then received either normal saline (NS) control, foam control (F), talc slurry (TS, 2 mg/g) or talc foam (TF, 2 mg/g). Airspace volume was evaluated by CT, lungs/pleura were collected, and percent fibrosis was determined. Results: The TF group had significantly better survival than the TS group (21 vs 13.5 days, p < 0.0001). The average effusion volume was less in the talc groups compared to the control group (140 vs 628 μL, p < 0.001). TF induced significant lung fibrosis (p < 0.01), similar to TS. On CT, TF significantly (p < 0.05) reduced loss of right lung volume (by 30–40%) compared to the control group. This was not seen with TS (p > 0.05). Conclusions: This report describes using a novel talc foam delivery system for the treatment of MPE. In the LL/2 model, mice treated with the TF had better survival outcomes and less reduction of lung volume than mice treated with the standard of care TS. These data provide support for translational efforts to move talc foam from animal models into clinical trials.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Lung cancer	ru_RU
dc.subject	Metastatic cancer	ru_RU
dc.subject	Talc	ru_RU
dc.subject	Pleurodesis	ru_RU
dc.subject	Malignant pleural effusion	ru_RU
dc.subject	Mouse model	ru_RU
dc.subject	Sclerosing agent	ru_RU
dc.subject	Thermosensitive hydrogel	ru_RU
dc.title	An improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion	ru_RU
dc.type	Articles in international journals and collections	ru_RU