Form of presentation | Articles in international journals and collections |
Year of publication | 2020 |
Язык | английский |
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Chumanova Arina Arkadevna, author
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Guerrero Cindy , author
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Bibliographic description in the original language |
Facilitation of Serotonin-Induced Signaling by the Migraine Mediator CGRP in Rat Trigeminal Neurons |
Annotation |
BioNanoScience |
Keywords |
CGRP, trigeminal nerve |
The name of the journal |
BioNanoScience
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Please use this ID to quote from or refer to the card |
https://repository.kpfu.ru/eng/?p_id=235428&p_lang=2 |
Resource files | |
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Full metadata record ![](https://shelly.kpfu.ru/pdf/picture/arrow_black_right.gif) |
Field DC |
Value |
Language |
dc.contributor.author |
Chumanova Arina Arkadevna |
ru_RU |
dc.contributor.author |
Guerrero Cindy |
ru_RU |
dc.date.accessioned |
2020-01-01T00:00:00Z |
ru_RU |
dc.date.available |
2020-01-01T00:00:00Z |
ru_RU |
dc.date.issued |
2020 |
ru_RU |
dc.identifier.citation |
Facilitation of Serotonin-Induced Signaling by the Migraine Mediator CGRP in Rat Trigeminal Neurons |
ru_RU |
dc.identifier.uri |
https://repository.kpfu.ru/eng/?p_id=235428&p_lang=2 |
ru_RU |
dc.description.abstract |
BioNanoScience |
ru_RU |
dc.description.abstract |
The monoamine neurotransmitter serotonin (5-HT) and the neuropeptide calcitonin gene-related peptide (CGRP) play an important role in migraine pathophysiology. To study potential interplay between 5-HT and CGRP in peripheral trigeminal nociception, we performed calcium imagining and patch clamp studies in rat trigeminal ganglia cells. We found that 5-HT activated Ca²⁺ transients in 18 % of trigeminal ganglia neurons. Exposure of trigeminal cells to CGRP significantly increased the number of 5-HT positive cells to 35 % and increased the amplitude of 5-HT-induced Ca²⁺ transients. Using patch clamp technique, we show that 37 % percent of trigeminal cells generated desensitizing membrane currents suggesting functional expression of 5-HT3 receptors. These responses were partially co-localized either with ATP-gated or capsaicin-sensitive neurons. Exposure to CGRP for 2 h increased the current density in the ATP-sensitive fraction of trigeminal neurons. |
ru_RU |
dc.language.iso |
ru |
ru_RU |
dc.subject |
CGRP |
ru_RU |
dc.subject |
trigeminal nerve |
ru_RU |
dc.title |
Facilitation of Serotonin-Induced Signaling by the Migraine Mediator CGRP in Rat Trigeminal Neurons |
ru_RU |
dc.type |
Articles in international journals and collections |
ru_RU |
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