KFU. Card publication. Analyzing the age diversity of patients with colorectal cancer

KAZAN
FEDERAL UNIVERSITY

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ANALYZING THE AGE DIVERSITY OF PATIENTS WITH COLORECTAL CANCER

Form of presentation

Articles in international journals and collections

Year of publication

2020

Язык

английский

Authors, employees of KFU

Doynikova Anastasiya Nikolaevna, author

Zelenikhin Pavel Valerevich, author

Ilinskaya Olga Nikolaevna, author

Kharitonova Mayya Aleksandrovna, author

Bibliographic description in the original language

Ilinskaya, O.N. Analyzing the age diversity of patients with colorectal cancer / O. N. Ilinskaya, M. A. Kharitonova, A. N. Doynikova, B.I. Gataullin, P.V. Zelenikhin // International Journal of Pharmaceutical Research. – 2020.- V.12, №.1. – P.768-774. https://doi.org/10.31838/ijpr/2020.12.01.149

Annotation

International Journal of Pharmaceutical Research

Keywords

colorectal cancer, KRAS, microbiome, high-resolution melting method, metagenomic sequencing

The name of the journal

International Journal of Pharmaceutical Research

URL

https://doi.org/10.31838/ijpr/2020.12.01.149

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=235814&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Doynikova Anastasiya Nikolaevna	ru_RU
dc.contributor.author	Zelenikhin Pavel Valerevich	ru_RU
dc.contributor.author	Ilinskaya Olga Nikolaevna	ru_RU
dc.contributor.author	Kharitonova Mayya Aleksandrovna	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Ilinskaya, O.N. Analyzing the age diversity of patients with colorectal cancer / O. N. Ilinskaya, M. A. Kharitonova, A. N. Doynikova, B.I. Gataullin, P.V. Zelenikhin // International Journal of Pharmaceutical Research. – 2020.- V.12, №.1. – P.768-774. https://doi.org/10.31838/ijpr/2020.12.01.149	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=235814&p_lang=2	ru_RU
dc.description.abstract	International Journal of Pharmaceutical Research	ru_RU
dc.description.abstract	Of the goal of this investigation is to assess the number of primary diseases with colorectal cancer (CRC). Based on this study the number has increased in recent 50 years in Russia. Analysis of patients with diagnosed rectal cancer in the RT revealed that the overall incidence of KRAS mutations was 33%, 68% of cases with mutations in the 12th codon, 33% of the detected mutant KRASs are homoduplexes. Patients older than 60 years carry the mutant KRAS, which nullifies the effectiveness of Epidermal Growth Factor receptor (EFGR) inhibitors, in only 10% of cases. In the group of patients younger than 50 years, KRAS mutations were found in 58.3% of cases. The microbial profile of the biopsy specimens revealed a tendency for phylum Bacteroides and Enterobacteriaceae to predominate on intact epithelium and replace them with tumor genera Faecalibacterium, Streptococcus and Fusobacterium on tumor. The taxonomic structure of bacterial communities of biopsy specimens is diverse; in tumor tissue, diversity can both decrease and increase. The representation of the Prevotella genus in the epithelium with the mutant KRAS gene was increased in 50% of cases. Expanding the spectrum of molecular targets in the epithelium and intestinal microbiome should ensure the effectiveness of personified antitumor therapy.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	colorectal cancer	ru_RU
dc.subject	KRAS	ru_RU
dc.subject	microbiome	ru_RU
dc.subject	high-resolution melting method	ru_RU
dc.subject	metagenomic sequencing	ru_RU
dc.title	Analyzing the age diversity of patients with colorectal cancer	ru_RU
dc.type	Articles in international journals and collections	ru_RU