KFU. Card publication. Bacillus pumilus ribonuclease rescues mice infected by double-stranded RNA-containing reovirus serotype 1

KAZAN
FEDERAL UNIVERSITY

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BACILLUS PUMILUS RIBONUCLEASE RESCUES MICE INFECTED BY DOUBLE-STRANDED RNA-CONTAINING REOVIRUS SEROTYPE 1

Form of presentation

Articles in international journals and collections

Year of publication

2020

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Authors, employees of KFU

Efimova Marina Anatolevna, author

Ilinskaya Olga Nikolaevna, author

Kolpakov Aleksey Ivanovich, author

Ulyanova Vera Vladimirovna, author

Shakh Makhmud Raikhan , author

Shuralev Eduard Arkadevich, author

Other authors

Ravilov Rustam Kh., author

Bibliographic description in the original language

Shah Mahmud R. Bacillus pumilus ribonuclease rescues mice infected by double-stranded RNA-containing reovirus serotype 1 / R. Shah Mahmud, M.A Efimova, V. Ulyanova, R. Ravilov, E. Shuralev, A. Kolpakov, O. Ilinskaya // Virus Research. - 2020. - V.286. - Art. � 198086. DOI: 10.1016/j.virusres.2020.198086

Annotation

Here, we first have shown that RNase from Bacillus pumilus (binase) acts as an antiviral agent at the level of the whole animal organism infected by Mammalian orthoreovirus 1 strain Lang (TL1). The results obtained on the mice model infected with 10 LD50 and 20 LD50 doses of reovirus indicate the restoration of mice physiological parameters under binase treatment at the dose of 50 μg/mouse. Thus, our research supports the relevance of binase as a promising antiviral agent that affects viral RNA.

Keywords

reovirus serotype 1, strain Lang, binase, ribonuclease, mice infection, antiviral

The name of the journal

Virus Research

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087749764&doi=10.1016%2fj.virusres.2020.198086&partnerID=40&md5=aa0b137d63ddb6339df2875c702660ea

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=236666&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Efimova Marina Anatolevna	ru_RU
dc.contributor.author	Ilinskaya Olga Nikolaevna	ru_RU
dc.contributor.author	Kolpakov Aleksey Ivanovich	ru_RU
dc.contributor.author	Ulyanova Vera Vladimirovna	ru_RU
dc.contributor.author	Shakh Makhmud Raikhan	ru_RU
dc.contributor.author	Shuralev Eduard Arkadevich	ru_RU
dc.contributor.author	Ravilov Rustam Kh.	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Shah Mahmud R. Bacillus pumilus ribonuclease rescues mice infected by double-stranded RNA-containing reovirus serotype 1 / R. Shah Mahmud, M.A Efimova, V. Ulyanova, R. Ravilov, E. Shuralev, A. Kolpakov, O. Ilinskaya // Virus Research. - 2020. - V.286. - Art. � 198086. DOI: 10.1016/j.virusres.2020.198086	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=236666&p_lang=2	ru_RU
dc.description.abstract	Virus Research	ru_RU
dc.description.abstract	Here, we first have shown that RNase from Bacillus pumilus (binase) acts as an antiviral agent at the level of the whole animal organism infected by Mammalian orthoreovirus 1 strain Lang (TL1). The results obtained on the mice model infected with 10 LD50 and 20 LD50 doses of reovirus indicate the restoration of mice physiological parameters under binase treatment at the dose of 50 μg/mouse. Thus, our research supports the relevance of binase as a promising antiviral agent that affects viral RNA.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	reovirus serotype 1	ru_RU
dc.subject	strain Lang	ru_RU
dc.subject	binase	ru_RU
dc.subject	ribonuclease	ru_RU
dc.subject	mice infection	ru_RU
dc.subject	antiviral	ru_RU
dc.title	Bacillus pumilus ribonuclease rescues mice infected by double-stranded RNA-containing reovirus serotype 1	ru_RU
dc.type	Articles in international journals and collections	ru_RU