KFU. Card publication. Direct interaction of fibrinogen with lipid microparticles modulates clotting kinetics and clot structure.

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

DIRECT INTERACTION OF FIBRINOGEN WITH LIPID MICROPARTICLES MODULATES CLOTTING KINETICS AND CLOT STRUCTURE.

Form of presentation

Articles in international journals and collections

Year of publication

2020

��

��

Authors, employees of KFU

Salnikov Vadim Vladimirovich, author

Other authors

Zuev Yuriy Fedorovich, author

Bibliographic description in the original language

Dzhigangir Faizullin, Yuliya Valiullina, Vadim Salnikov, , Yuriy Zuev. Direct interaction of fibrinogen with lipid microparticles modulates clotting kinetics and clot structure. Nanomedicine: Nanotechnology, Biology, and Medicine 23 (2020)

Annotation

Extensive studies revealed the role of blood lipid microparticles (liposomes, microvesicles) in activation of coagulation cascade. The direct interaction of fibrinogen/fibrin with lipid surfaces and its consequence for hemostasis received much less attention. We observed pronounced changes in both clot morphology and kinetics of fibrin clotting in the presence of artificial liposomes. The evidence was obtained that lipid microparticles per se present a diffusion barrier to the three-dimensional fibril assembling and pose spatial restrictions for fiber elongation. On the other hand, fibrinogen adsorption results in its high local concentration on liposome surface that accelerates fibrin polymerization. Adsorption induces Fg secondary structure alterations which may contribute to the abnormal clot morphology. In dependence on lipid composition and size of microparticles, the interplay of all the outlined mechanisms determines functionally important changes of clot morphology. The obtained results contribute to the knowledge of clotting mechanisms in the presence of artificial and natural lipid microparticles.

Keywords

Liposomes; Fibrinogen; Adsorption; Fibrin clotting

The name of the journal

Nanomedicine

URL

https://www.sciencedirect.com/science/article/pii/S1549963419301820

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=236722&p_lang=2

Resource files

File name	Size (MB)	Format
Fayzullin_ea_2020.pdf	0,48	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Salnikov Vadim Vladimirovich	ru_RU
dc.contributor.author	Zuev Yuriy Fedorovich	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Dzhigangir Faizullin, Yuliya Valiullina, Vadim Salnikov, , Yuriy Zuev. Direct interaction of fibrinogen with lipid microparticles modulates clotting kinetics and clot structure. Nanomedicine: Nanotechnology, Biology, and Medicine 23 (2020)	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=236722&p_lang=2	ru_RU
dc.description.abstract	Nanomedicine	ru_RU
dc.description.abstract	Extensive studies revealed the role of blood lipid microparticles (liposomes, microvesicles) in activation of coagulation cascade. The direct interaction of fibrinogen/fibrin with lipid surfaces and its consequence for hemostasis received much less attention. We observed pronounced changes in both clot morphology and kinetics of fibrin clotting in the presence of artificial liposomes. The evidence was obtained that lipid microparticles per se present a diffusion barrier to the three-dimensional fibril assembling and pose spatial restrictions for fiber elongation. On the other hand, fibrinogen adsorption results in its high local concentration on liposome surface that accelerates fibrin polymerization. Adsorption induces Fg secondary structure alterations which may contribute to the abnormal clot morphology. In dependence on lipid composition and size of microparticles, the interplay of all the outlined mechanisms determines functionally important changes of clot morphology. The obtained results contribute to the knowledge of clotting mechanisms in the presence of artificial and natural lipid microparticles.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Direct interaction of fibrinogen with lipid microparticles modulates clotting kinetics and clot structure.	ru_RU
dc.type	Articles in international journals and collections	ru_RU