KFU. Card publication. Soft Nanocontainers Based on Hydroxyethylated Geminis: Role of Spacer in Self-Assembling, Solubilization, and Complexation with Oligonucleotide

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SOFT NANOCONTAINERS BASED ON HYDROXYETHYLATED GEMINIS: ROLE OF SPACER IN SELF-ASSEMBLING, SOLUBILIZATION, AND COMPLEXATION WITH OLIGONUCLEOTIDE

Form of presentation

Articles in international journals and collections

Year of publication

2020

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Authors, employees of KFU

Salnikov Vadim Vladimirovich, author

Other authors

Zakharova Lyuciya Yarullovna, author

Bibliographic description in the original language

Dinar R. Gabdrakhmanov,Elmira A. Vasilieva,Mikhail A. Voronin,Darya A. Kuznetsova,Farida G. Valeeva,Alla B. Mirgorodskaya,Svetlana S. Lukashenko,Valery M. Zakharov,Alexander R. Mukhitov,�Dzhigangir A. Faizullin,Vadim V. Salnikov,Victor V. Syakaev,?Shamil K. Latypov,Yuriy F. Zuev,and Lucia Ya. Zakharova/ Soft Nanocontainers Based on Hydroxyethylated Geminis: Role ofSpacer in Self-Assembling, Solubilization, and Complexation with Oligonucleotide. J. Phys. Chem. C 2020, 124, 2178−2192

Annotation

Self-organization of hydroxyethylated gemini surfactants with di ﬀ erent spacer fragments 16-s-16(OH) (s = 4, 6, 10, and 12) was studied in single solutions and in binary surfactant-oligonucleotide systems. Despite the fact that aggregation activity and solubilization capacity of aggregates decrease with an increase in spacer length, gemini with the longer spacer demonstrate superior binding capacity toward oligonucleotide as compared to single head surfactant and gemini analogs with shorter spacers. The detailed study testi ﬁ ed that gemini with longer spacers are characterized by a looser packing mode, a moist and more polar interior, and tend to show polymorphism. These features in combination with favorable geometry factor providing suitable orientation of components are probably responsible for the bene ﬁ cial lipoplex formation in the case of longer spacers. The e ﬀ ectiveness of oligonucleotide-surfactant complexation changes in the same order as transfection e ﬃ cacy mediated by these gemini reported earlier [Zakharova, L. et al. Colloids Surf. B, 2016, 140, 269 − 277], which indicates that physicochemical aspects probably play a key role upon the design of nonviral vectors and may be used for prediction of transfection e ﬃ cacy mediated by amphiphilic agents.

Keywords

Self-organization of hydroxyethylated gemini surfactants

The name of the journal

J. Phys. Chem. C

URL

https://www.researchgate.net/publication/338471150_Soft_Nanocontainers_Based_on_Hydroxyethylated_Geminis_Role_of_Spacer_in_Self-Assembling_Solubilization_and_Complexation_with_Oligonucleotide

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=236723&p_lang=2

Resource files

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Zacharova_2020.pdf	5,65	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Salnikov Vadim Vladimirovich	ru_RU
dc.contributor.author	Zakharova Lyuciya Yarullovna	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Dinar R. Gabdrakhmanov,Elmira A. Vasilieva,Mikhail A. Voronin,Darya A. Kuznetsova,Farida G. Valeeva,Alla B. Mirgorodskaya,Svetlana S. Lukashenko,Valery M. Zakharov,Alexander R. Mukhitov,�Dzhigangir A. Faizullin,Vadim V. Salnikov,Victor V. Syakaev,?Shamil K. Latypov,Yuriy F. Zuev,and Lucia Ya. Zakharova/ Soft Nanocontainers Based on Hydroxyethylated Geminis: Role ofSpacer in Self-Assembling, Solubilization, and Complexation with Oligonucleotide. J. Phys. Chem. C 2020, 124, 2178−2192	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=236723&p_lang=2	ru_RU
dc.description.abstract	J. Phys. Chem. C	ru_RU
dc.description.abstract	Self-organization of hydroxyethylated gemini surfactants with di ﬀ erent spacer fragments 16-s-16(OH) (s = 4, 6, 10, and 12) was studied in single solutions and in binary surfactant-oligonucleotide systems. Despite the fact that aggregation activity and solubilization capacity of aggregates decrease with an increase in spacer length, gemini with the longer spacer demonstrate superior binding capacity toward oligonucleotide as compared to single head surfactant and gemini analogs with shorter spacers. The detailed study testi ﬁ ed that gemini with longer spacers are characterized by a looser packing mode, a moist and more polar interior, and tend to show polymorphism. These features in combination with favorable geometry factor providing suitable orientation of components are probably responsible for the bene ﬁ cial lipoplex formation in the case of longer spacers. The e ﬀ ectiveness of oligonucleotide-surfactant complexation changes in the same order as transfection e ﬃ cacy mediated by these gemini reported earlier [Zakharova, L. et al. Colloids Surf. B, 2016, 140, 269 − 277], which indicates that physicochemical aspects probably play a key role upon the design of nonviral vectors and may be used for prediction of transfection e ﬃ cacy mediated by amphiphilic agents.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Soft Nanocontainers Based on Hydroxyethylated Geminis: Role of Spacer in Self-Assembling, Solubilization, and Complexation with Oligonucleotide	ru_RU
dc.type	Articles in international journals and collections	ru_RU