KFU. Card publication. Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine

KAZAN
FEDERAL UNIVERSITY

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URINE-DERIVED STEM CELLS: APPLICATIONS IN REGENERATIVE AND PREDICTIVE MEDICINE

Form of presentation

Articles in international journals and collections

Year of publication

2020

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Authors, employees of KFU

Rizvanov Albert Anatolevich, author

Shafigullina Aygul Kasyymovna, author

Other authors

Guida Bento , author

Macedo Maria Paula , author

Oliveira Paulo J. , author

Sardão Vilma A. , author

Bibliographic description in the original language

Guida Bento et al. Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine / Guida Bento, Aygul K. Shafigullina, Albert A. Rizvanov, Vilma A. Sardão, Maria Paula Macedo and Paulo J. Oliveira // Cells. 2020 Mar; 9(3): 573.

Annotation

Despite being a biological waste, human urine contains a small population of cells with self-renewal capacity and differentiation potential into several cell types. Being derived from the convoluted tubules of nephron, renal pelvis, ureters, bladder and urethra, urine-derived stem cells (UDSC) have a similar phenotype to mesenchymal stroma cells (MSC) and can be reprogrammed into iPSC (induced pluripotent stem cells). Having simple, safer, low-cost and noninvasive collection procedures, the interest in UDSC has been growing in the last decade. With great potential in regenerative medicine applications, UDSC can also be used as biological models for pharmacology and toxicology tests. This review describes UDSC biological characteristics and differentiation potential and their possible use, including the potential of UDSC-derived iPSC to be used in drug discovery and toxicology, as well as in regenerative medicine. Being a new cellular platform amenable to noninvasive collection for disease stratification and personalized therapy could be a future application for UDSC.

Keywords

urine-derived stem cells; personalized medicine; regenerative medicine; induced-pluripotent stem cells

The name of the journal

CELLS

URL

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140531/

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=240972&p_lang=2

Resource files

File name	Size (MB)	Format
titulnik_stati.jpg	0,13	jpg	show / download
manuscript.v6__1_.pdf	0,52	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Shafigullina Aygul Kasyymovna	ru_RU
dc.contributor.author	Guida Bento	ru_RU
dc.contributor.author	Macedo Maria Paula	ru_RU
dc.contributor.author	Oliveira Paulo J.	ru_RU
dc.contributor.author	Sardão Vilma A.	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Guida Bento et al. Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine / Guida Bento, Aygul K. Shafigullina, Albert A. Rizvanov, Vilma A. Sardão, Maria Paula Macedo and Paulo J. Oliveira // Cells. 2020 Mar; 9(3): 573.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=240972&p_lang=2	ru_RU
dc.description.abstract	CELLS	ru_RU
dc.description.abstract	Despite being a biological waste, human urine contains a small population of cells with self-renewal capacity and differentiation potential into several cell types. Being derived from the convoluted tubules of nephron, renal pelvis, ureters, bladder and urethra, urine-derived stem cells (UDSC) have a similar phenotype to mesenchymal stroma cells (MSC) and can be reprogrammed into iPSC (induced pluripotent stem cells). Having simple, safer, low-cost and noninvasive collection procedures, the interest in UDSC has been growing in the last decade. With great potential in regenerative medicine applications, UDSC can also be used as biological models for pharmacology and toxicology tests. This review describes UDSC biological characteristics and differentiation potential and their possible use, including the potential of UDSC-derived iPSC to be used in drug discovery and toxicology, as well as in regenerative medicine. Being a new cellular platform amenable to noninvasive collection for disease stratification and personalized therapy could be a future application for UDSC.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine	ru_RU
dc.type	Articles in international journals and collections	ru_RU