KFU. Card publication. Solubilization of azo-dye-modified isatin derivative by amphiphilic carboxyresorcinarenes: the effect of macrocycle structure on the supramolecular association.

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SOLUBILIZATION OF AZO-DYE-MODIFIED ISATIN DERIVATIVE BY AMPHIPHILIC CARBOXYRESORCINARENES: THE EFFECT OF MACROCYCLE STRUCTURE ON THE SUPRAMOLECULAR ASSOCIATION.

Form of presentation

Articles in international journals and collections

Year of publication

2018

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Authors, employees of KFU

Bogdanov Andrey Vladimirovich, author

Ermakova Alina Marselovna, author

Konovalov Aleksandr Ivanovich, author

Mironov Vladimir Fedorovich, author

Morozova Yuliya Ernestovna, author

Shalaeva Yana Viktorovna, author

Other authors

Voloshina Aleksandra Dmitrievna, author

Zobov Vladimir Vasilevich, author

Kadirov Marsil Kakhirovich, author

Nizameev Irek Rashatovich, author

Syakaev Viktor Vasilevich, author

Bibliographic description in the original language

Syakaev V. V., Solubilization of azo-dye-modified isatin derivative by amphiphilic carboxyresorcinarenes: the effect of macrocycle structure on the supramolecular association. / Syakaev V. V., Morozova Ju. E., Bogdanov A. V., Shalaeva Ya. V., Ermakova A. M., Voloshina A. D., Zobov V. V., Nizameev I. R., Kadirov M. K., Mironov V. F., Konovalov A. I. // Colloids Surf., A. – 2018. – V. 553. – P. 368-377. DOI: 10.1016/j.colsurfa.2018.05.078

Annotation

Here we present the consecutive study of colloid systems formed by novel isatin derivative as compound with high pharmacological potential and series of carboxyresorcinarenes. The azo-modiﬁed isatin derivative bearing ammonium moiety (I-3) was synthesized and its antimicrobial activity was investigated. To increase its solubility the solubilization experiment using amphiphilic carboxyresorcinarenes, characterized by low hemolytic activity, was carried out. The I-3 – macrocycles systems were studied by NMR, UV–vis, DLS and TEM. The FT PGSE and 2D NOESY NMR methods demonstrated, that solubilization of I-3 is caused by the incorporation of its molecules in the hydrophobic part of the macrocycles associates. Herewith the loading eﬃciency of I-3 into the macro- cycles associates was reached of 20–30% due to the change of the volume of hydrophobic part of associates by varying the length and structure of hydrophobic substituents of macrocyclic amphiphiles

Keywords

Isatin derivative, NMR spectroscopy, Resorcinarene, Solubilization, Supramolecular systems

The name of the journal

Colloids and Surfaces A: Physicochemical and Engineering Aspects

URL

https://www.sciencedirect.com/science/article/pii/S0927775718304540?via%3Dihub

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=241485&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Bogdanov Andrey Vladimirovich	ru_RU
dc.contributor.author	Ermakova Alina Marselovna	ru_RU
dc.contributor.author	Konovalov Aleksandr Ivanovich	ru_RU
dc.contributor.author	Mironov Vladimir Fedorovich	ru_RU
dc.contributor.author	Morozova Yuliya Ernestovna	ru_RU
dc.contributor.author	Shalaeva Yana Viktorovna	ru_RU
dc.contributor.author	Voloshina Aleksandra Dmitrievna	ru_RU
dc.contributor.author	Zobov Vladimir Vasilevich	ru_RU
dc.contributor.author	Kadirov Marsil Kakhirovich	ru_RU
dc.contributor.author	Nizameev Irek Rashatovich	ru_RU
dc.contributor.author	Syakaev Viktor Vasilevich	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Syakaev V. V., Solubilization of azo-dye-modified isatin derivative by amphiphilic carboxyresorcinarenes: the effect of macrocycle structure on the supramolecular association. / Syakaev V. V., Morozova Ju. E., Bogdanov A. V., Shalaeva Ya. V., Ermakova A. M., Voloshina A. D., Zobov V. V., Nizameev I. R., Kadirov M. K., Mironov V. F., Konovalov A. I. // Colloids Surf., A. – 2018. – V. 553. – P. 368-377. DOI: 10.1016/j.colsurfa.2018.05.078	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=241485&p_lang=2	ru_RU
dc.description.abstract	Colloids and Surfaces A: Physicochemical and Engineering Aspects	ru_RU
dc.description.abstract	Here we present the consecutive study of colloid systems formed by novel isatin derivative as compound with high pharmacological potential and series of carboxyresorcinarenes. The azo-modiﬁed isatin derivative bearing ammonium moiety (I-3) was synthesized and its antimicrobial activity was investigated. To increase its solubility the solubilization experiment using amphiphilic carboxyresorcinarenes, characterized by low hemolytic activity, was carried out. The I-3 – macrocycles systems were studied by NMR, UV–vis, DLS and TEM. The FT PGSE and 2D NOESY NMR methods demonstrated, that solubilization of I-3 is caused by the incorporation of its molecules in the hydrophobic part of the macrocycles associates. Herewith the loading eﬃciency of I-3 into the macro- cycles associates was reached of 20–30% due to the change of the volume of hydrophobic part of associates by varying the length and structure of hydrophobic substituents of macrocyclic amphiphiles	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Isatin derivative	ru_RU
dc.subject	NMR spectroscopy	ru_RU
dc.subject	Resorcinarene	ru_RU
dc.subject	Solubilization	ru_RU
dc.subject	Supramolecular systems	ru_RU
dc.title	Solubilization of azo-dye-modified isatin derivative by amphiphilic carboxyresorcinarenes: the effect of macrocycle structure on the supramolecular association.	ru_RU
dc.type	Articles in international journals and collections	ru_RU