KFU. Card publication. Translesion DNA Synthesis and Carcinogenesis

KAZAN
FEDERAL UNIVERSITY

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- 中文
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TRANSLESION DNA SYNTHESIS AND CARCINOGENESIS

Form of presentation

Articles in Russian journals and collections

Year of publication

2020

Язык

английский

Authors, employees of KFU

Khayrullin Rafil Fidailevich, author

Other authors

Makarova Alena Vladimirovna, author

Bibliographic description in the original language

Shilkin E., Boldinova E., Stolyarenko A., Goncharova RI., Chuprov-Netochin RN., Khairullin RF, Smal MP, Makarova AV Translesion DNA Synthesis and Carcinogenesis. Biochemistry Moscow 85, 425–435 (2020).

Annotation

Tens of thousands of DNA lesions are formed in mammalian cells each day. DNA translesion synthesis is the main mechanism of cell defense against unrepaired DNA lesions. DNA polymerases iota (Pol ι), eta (Pol η), kappa (Pol κ), and zeta (Pol ζ) have active sites that are less stringent toward the DNA template structure and efficiently incorporate nucleotides opposite DNA lesions. However, these polymerases display low accuracy of DNA synthesis and can introduce mutations in genomic DNA. Impaired functioning of these enzymes can lead to an increased risk of cancer.

Keywords

DNA Synthesis, Carcinogenesis, polymerases, mutation

The name of the journal

Biochemistry (Moscow)

URL

https://link.springer.com/article/10.1134/S0006297920040033#citeas

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=242007&p_lang=2

Resource files

File name	Size (MB)	Format
F_Article.jpg	0,11	jpg	show / download
F_Shilkin2020_Article_TranslesionDNASynthesisAndCarc.pdf	0,42	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Khayrullin Rafil Fidailevich	ru_RU
dc.contributor.author	Makarova Alena Vladimirovna	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Shilkin E., Boldinova E., Stolyarenko A., Goncharova RI., Chuprov-Netochin RN., Khairullin RF, Smal MP, Makarova AV Translesion DNA Synthesis and Carcinogenesis. Biochemistry Moscow 85, 425–435 (2020).	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=242007&p_lang=2	ru_RU
dc.description.abstract	Biochemistry (Moscow)	ru_RU
dc.description.abstract	Tens of thousands of DNA lesions are formed in mammalian cells each day. DNA translesion synthesis is the main mechanism of cell defense against unrepaired DNA lesions. DNA polymerases iota (Pol ι), eta (Pol η), kappa (Pol κ), and zeta (Pol ζ) have active sites that are less stringent toward the DNA template structure and efficiently incorporate nucleotides opposite DNA lesions. However, these polymerases display low accuracy of DNA synthesis and can introduce mutations in genomic DNA. Impaired functioning of these enzymes can lead to an increased risk of cancer.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	DNA Synthesis	ru_RU
dc.subject	Carcinogenesis	ru_RU
dc.subject	polymerases	ru_RU
dc.subject	mutation	ru_RU
dc.title	Translesion DNA Synthesis and Carcinogenesis	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU