KFU. Card publication. Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolone derivatives as new anti-cancer agents

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-QUINOLYL-1,3-TROPOLONE DERIVATIVES AS NEW ANTI-CANCER AGENTS

Form of presentation

Articles in international journals and collections

Year of publication

2021

��

��

Authors, employees of KFU

Abramova Zinaida Ivanovna, author

Bulatov Emil Rafaelevich, author

Bumber Yanis Alekseevich, author

Serebriyskiy Ilya Genrikhovich, author

Topchu Yuliya Alekseevna, author

Usak Mukhammet , author

Authors, postgraduates KFU

Mazitova Aleksandra Maratovna, postgraduate kfu

Bibliographic description in the original language

Gusakov, E. Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolon derivatives as new anti-cancer agents /A. Gusakov, Iu. A. Topchu, A. M. Mazitova, I. V. Dorogan, E. R. Bulatov, I. G. Serebriiskii, Z. I. Abramova, I. O. Tupaeva, O. P. Demidov, D. N. Toan, T. D. Lam, D. N. Bang, Y.A. Boumber, Y. A. Sayapin, V. I. Minkin. // RSC Advances.- 2021.- V.11.-P.4555-4571(Q1 IF3.119)

Annotation

biologic effects. We developed a series of new 2-quinolyl-1,3-tropolones derivatives that were prepared by the acid-catalyzed reaction of 4,7-dichloro-2-methylquinolines with 1,2-benzoquinones. 2-Quinolyl-1,3-tropolones have been synthesized and tested for their anti-proliferative activity against several human cancer cell lines. Two compounds (3d and mixture B of 3i?k) showed excellent activity against six cancer cell lines of different tissue of origin. The promising compounds 3d and mixture B of 3i?k also demonstrated induction of apoptotic cell death of ovarian cancer (OVCAR-3, OVCAR-8) and colon cancer (HCT 116) cell lines and affected ERK signaling. In summary, 2-quinolyl-1,3-tropolones are promising compounds for development of effective anticancer agents.

Keywords

Design, synthesis, and biological, 2-quinolyl-1,3-tropolon, anti-cancer agents

The name of the journal

RSC Advances

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100133501&doi=10.1039%2fd0ra10610k&partnerID=40&md5=d4fd3935525b6f2447cb01f1ebbd4ac8

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=249941&p_lang=2

Resource files

File name	Size (MB)	Format
F_RSC_Advances_2021.pdf	1,56	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abramova Zinaida Ivanovna	ru_RU
dc.contributor.author	Bulatov Emil Rafaelevich	ru_RU
dc.contributor.author	Bumber Yanis Alekseevich	ru_RU
dc.contributor.author	Serebriyskiy Ilya Genrikhovich	ru_RU
dc.contributor.author	Topchu Yuliya Alekseevna	ru_RU
dc.contributor.author	Usak Mukhammet	ru_RU
dc.contributor.author	Usak Mukhammet	ru_RU
dc.contributor.author	Mazitova Aleksandra Maratovna	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Gusakov, E. Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolon derivatives as new anti-cancer agents /A. Gusakov, Iu. A. Topchu, A. M. Mazitova, I. V. Dorogan, E. R. Bulatov, I. G. Serebriiskii, Z. I. Abramova, I. O. Tupaeva, O. P. Demidov, D. N. Toan, T. D. Lam, D. N. Bang, Y.A. Boumber, Y. A. Sayapin, V. I. Minkin. // RSC Advances.- 2021.- V.11.-P.4555-4571(Q1 IF3.119)	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=249941&p_lang=2	ru_RU
dc.description.abstract	RSC Advances	ru_RU
dc.description.abstract	biologic effects. We developed a series of new 2-quinolyl-1,3-tropolones derivatives that were prepared by the acid-catalyzed reaction of 4,7-dichloro-2-methylquinolines with 1,2-benzoquinones. 2-Quinolyl-1,3-tropolones have been synthesized and tested for their anti-proliferative activity against several human cancer cell lines. Two compounds (3d and mixture B of 3i?k) showed excellent activity against six cancer cell lines of different tissue of origin. The promising compounds 3d and mixture B of 3i?k also demonstrated induction of apoptotic cell death of ovarian cancer (OVCAR-3, OVCAR-8) and colon cancer (HCT 116) cell lines and affected ERK signaling. In summary, 2-quinolyl-1,3-tropolones are promising compounds for development of effective anticancer agents.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Design	ru_RU
dc.subject	synthesis	ru_RU
dc.subject	and biological	ru_RU
dc.subject	2-quinolyl-1	ru_RU
dc.subject	3-tropolon	ru_RU
dc.subject	anti-cancer agents	ru_RU
dc.title	Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolone derivatives as new anti-cancer agents	ru_RU
dc.type	Articles in international journals and collections	ru_RU