KFU. Card publication. Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity

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BLOOD SERUM CYTOKINES IN PATIENTS WITH SUBACUTE SPINAL CORD INJURY: A PILOT STUDY TO SEARCH FOR BIOMARKERS OF INJURY SEVERITY

Form of presentation

Articles in international journals and collections

Year of publication

2021

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Authors, employees of KFU

Baychurina Irina Alekseevna, author

Garanina Ekaterina Evgenevna, author

Kostennikov Aleksandr Aleksandrovich, author

Masgutova Galina Andreevna, author

Mukhamedshina Yana Olegovna, author

Ogurcov Sergey Vasilevich, author

Rizvanov Albert Anatolevich, author

Shulman Ilya Aleksandrovich, author

Bibliographic description in the original language

Ogurcov S, Shulman I, Garanina E, Sabirov D, Baichurina I, Kuznetcov M, Masgutova G, Kostennikov A, Rizvanov A, James V, Mukhamedshina Y. Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity. Brain Sci. 2021 Mar 4;11(3):322. doi: 10.3390/brainsci11030322. PMID: 33806460; PMCID: PMC8000354.

Annotation

Brain Sciences

Keywords

blood serum; clinical trial; cytokine profile; inflammation; traumatic spinal cord injury

The name of the journal

Brain Sciences

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=251583&p_lang=2

Resource files

File name	Size (MB)	Format
brainsci_11_00322__1_.pdf	1,54	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Baychurina Irina Alekseevna	ru_RU
dc.contributor.author	Garanina Ekaterina Evgenevna	ru_RU
dc.contributor.author	Kostennikov Aleksandr Aleksandrovich	ru_RU
dc.contributor.author	Masgutova Galina Andreevna	ru_RU
dc.contributor.author	Mukhamedshina Yana Olegovna	ru_RU
dc.contributor.author	Ogurcov Sergey Vasilevich	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Shulman Ilya Aleksandrovich	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Ogurcov S, Shulman I, Garanina E, Sabirov D, Baichurina I, Kuznetcov M, Masgutova G, Kostennikov A, Rizvanov A, James V, Mukhamedshina Y. Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity. Brain Sci. 2021 Mar 4;11(3):322. doi: 10.3390/brainsci11030322. PMID: 33806460; PMCID: PMC8000354.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=251583&p_lang=2	ru_RU
dc.description.abstract	Brain Sciences	ru_RU
dc.description.abstract	Background. Despite considerable interest in the search for a spinal cord injury (SCI) therapy, there is a critical need to develop a panel of diagnostic biomarkers to determine injury severity. In this regard, there is a requirement for continuing research into the fundamental processes of neuroinflammatory and autoimmune reactions in SCI, identifying changes in the expression of cytokines. Methods. In this pilot study, an extended multiplex analysis of the cytokine profiles in the serum of patients at 2 weeks post-SCI (n = 28) was carried out, together with an additional assessment of neuron-specific enolase (NSE) and vascular endothelial growth factor (VEGF) levels by enzyme-linked immunosorbent assay. A total of 16 uninjured subjects were enrolled as controls. Results. The data obtained showed a large elevation of IFNγ (>52 fold), CCL27 (>13 fold), and CCL26 (>8 fold) 2 weeks after SCI. The levels of cytokines CXCL5, CCL11, CXCL11, IL10, TNFα, and MIF were different between patients with baseline American Spinal Injury Association Impairment Scale (AIS) grades of A or B, whilst IL2 (>2 fold) and MIP-3a (>6 fold) were significantly expressed in the cervical and thoracic regions. There was a trend towards increasing levels of NSE. However, the difference in NSE was lost when the patient set was segregated based on AIS group. Conclusions. Our pilot research demonstrates that serum concentrations of cytokines can be used as an affordable and rapid detection tool to accurately stratify SCI severity in patients.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity	ru_RU
dc.type	Articles in international journals and collections	ru_RU