Form of presentation | Articles in international journals and collections |
Year of publication | 2021 |
Язык | русский |
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Gerasimova Elena Vyacheslavovna, author
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Bibliographic description in the original language |
ElenaGerasimova,Gulshat Burkhanova,Kseniya Chernova, AndreyZakharov,,Daniel Enikeev, Nail Khaertdinov, Rashid Giniatullin,Guzel Sitdikova// Hyperhomocysteinemia increases susceptibility to cortical spreading depression associated with photophobia, mechanical allodynia, and anxiety in rats// Behavioural Brain Research.-2021.- V. 409,.-r.1-8
https://doi.org/10.1016/j.bbr.2021.113324.
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Annotation |
Behavioural Brain Research |
Keywords |
Migraine, Hyperhomocysteinemia,Cortical spreading depression
Cortical excitability,Allodynia,Anxiety |
The name of the journal |
Behavioural Brain Research
|
Please use this ID to quote from or refer to the card |
https://repository.kpfu.ru/eng/?p_id=252550&p_lang=2 |
Full metadata record ![](https://shelly.kpfu.ru/pdf/picture/arrow_black_right.gif) |
Field DC |
Value |
Language |
dc.contributor.author |
Gerasimova Elena Vyacheslavovna |
ru_RU |
dc.date.accessioned |
2021-01-01T00:00:00Z |
ru_RU |
dc.date.available |
2021-01-01T00:00:00Z |
ru_RU |
dc.date.issued |
2021 |
ru_RU |
dc.identifier.citation |
ElenaGerasimova,Gulshat Burkhanova,Kseniya Chernova, AndreyZakharov,,Daniel Enikeev, Nail Khaertdinov, Rashid Giniatullin,Guzel Sitdikova// Hyperhomocysteinemia increases susceptibility to cortical spreading depression associated with photophobia, mechanical allodynia, and anxiety in rats// Behavioural Brain Research.-2021.- V. 409,.-р.1-8
https://doi.org/10.1016/j.bbr.2021.113324.
|
ru_RU |
dc.identifier.uri |
https://repository.kpfu.ru/eng/?p_id=252550&p_lang=2 |
ru_RU |
dc.description.abstract |
Behavioural Brain Research |
ru_RU |
dc.description.abstract |
Epidemiological data suggest that elevated homocysteine is associated with migraine with aura. However, how
homocysteine contributes to migraine is still unclear. Here, we tested whether hyperhomocysteinemia (hHCY)
promotes cortical spreading depression (CSD), a phenomenon underlying migraine with aura, and whether hHCY
contributes to pain behavior. hHCY was induced by dietary methionine in female rats while the testing was
performed on their 6–8week-old offspring. CSD and multiple unit activity (MUA) induced by KCl were recorded
from the primary somatosensory cortex, S1, using multichannel electrodes. In hHCY rats, compared to control,
we found: i) higher probability of CSD occurrence; ii) induction of CSD by lower concentrations of KCl; iii) faster
horizontal propagation of CSD; iv) smaller CSD with longer duration; v) higher frequency of MUA at CSD onset
along with slower reappearance. Rats with hHCY demonstrated high level of locomotor activity and grooming
while spent less time in the central area of the open field, indicating anxiety. These animals showed light
sensitivity and facial mechanical allodinia. Thus, hHCY acquired at birth promotes multiple features of migraine
such as higher cortical excitability, mechanical allodynia, photophobia, and anxiety. Our results provide the first
experimental explanation for the higher occurrence of migraine with aura in patients with hHCY. |
ru_RU |
dc.language.iso |
ru |
ru_RU |
dc.subject |
Migraine |
ru_RU |
dc.subject |
Hyperhomocysteinemia |
ru_RU |
dc.subject |
Cortical spreading depression
Cortical excitability |
ru_RU |
dc.subject |
Allodynia |
ru_RU |
dc.subject |
Anxiety |
ru_RU |
dc.title |
Hyperhomocysteinemia increases susceptibility to cortical spreading depression associated with photophobia, mechanical allodynia, and anxiety in rats |
ru_RU |
dc.type |
Articles in international journals and collections |
ru_RU |
|