KFU. Card publication. Влияние некоторых белков аутофагии (LC3b и Beclin1) и апоптоза (Casp8 и Bcl2) на клиническое течение рака яичников

KAZAN
FEDERAL UNIVERSITY

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ВЛИЯНИЕ НЕКОТОРЫХ БЕЛКОВ АУТОФАГИИ (LC3B И BECLIN1) И АПОПТОЗА (CASP8 И BCL2) НА КЛИНИЧЕСКОЕ ТЕЧЕНИЕ РАКА ЯИЧНИКОВ

Form of presentation

Articles in Russian journals and collections

Year of publication

2021

Язык

русский

Authors, employees of KFU

Abramova Zinaida Ivanovna, author

Other authors

Afanaseva Zinaida Aleksandrovna, author

Garipov Karim Albertovich, author

Gafiullina Aliya Damirovna, author

Bibliographic description in the original language

Gafiullina A. D. Vliyanie nekotorykh belkov autofagii (LC3b i Beclin1) i apoptoza (Casp8 i Bcl2) na klinicheskoe techenie raka yaichnikov /A. D. Gafiullina, Z. A. Afanaseva, K. A. Garipov, Z. I. Abramova //Voprosy onkologii.- 2021.- T. 67, №4.- S.474-479 (Q4) https://elibrary.ru/item.asp?id=46503550&

Annotation

Treatment of ovarian cancer remains an important problem in practical oncology due to the increase in morbidity and mortality from this disease. The aim is to summarize the available literature data on the molecular mechanisms of the participation of various proteins of autophagy and apoptosis in the development, progression, formation of chemoresistance and in the assessment of the prognosis of epithelial ovarian cancer. Materials and methods. The search for information was carried out in the materials of the databases Medline, Cochrane Library, Elibrary, NCBI, RSCI, instructions for the medical use of drugs, using keywords in the title. Used 39 articles to write this systematic review. Results. The review examines the molecular mechanisms of autophagy and apoptosis involved in the progression of ovarian cancer and in the formation of resistance to anticancer drug therapy. It has been shown that modulation of autophagy and apoptosis can change the effectiveness of drug treatment for this tumor. Conclusion. Considering the literature data on the ambiguous role of autophagy and apoptosis in the course of ovarian cancer and the formation of resistance to antitumor treatment, further study is required and the search for new molecular targets for their modulation is required.

Keywords

обзор, эпителиальный рак яичников, аутофагия, апоптоз, препараты платины, химиорезистентность ХИМИОРЕЗИСТЕНТНОСТЬ

The name of the journal

Вопросы онкологии

URL

https://doi.org/10.37469/0507-3758-2021-67-4-474-479

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=253312&p_lang=2

Resource files

File name	Size (MB)	Format
F_Statya_Vliyanie_nekotorykh_belkov_autofagii__LC3b_i_Beclin__i_apotoza.pdf	1,27	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abramova Zinaida Ivanovna	ru_RU
dc.contributor.author	Afanaseva Zinaida Aleksandrovna	ru_RU
dc.contributor.author	Garipov Karim Albertovich	ru_RU
dc.contributor.author	Gafiullina Aliya Damirovna	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Гафиуллина А. Д. Влияние некоторых белков аутофагии (LC3b и Beclin1) и апоптоза (Casp8 и Bcl2) на клиническое течение рака яичников /А. Д. Гафиуллина, З. А. Афанасьева, К. А. Гарипов, З. И. Абрамова //Вопросы онкологии.- 2021.- Т. 67, №4.- С.474-479 (Q4) https://elibrary.ru/item.asp?id=46503550&	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=253312&p_lang=2	ru_RU
dc.description.abstract	Вопросы онкологии	ru_RU
dc.description.abstract	Treatment of ovarian cancer remains an important problem in practical oncology due to the increase in morbidity and mortality from this disease. The aim is to summarize the available literature data on the molecular mechanisms of the participation of various proteins of autophagy and apoptosis in the development, progression, formation of chemoresistance and in the assessment of the prognosis of epithelial ovarian cancer. Materials and methods. The search for information was carried out in the materials of the databases Medline, Cochrane Library, Elibrary, NCBI, RSCI, instructions for the medical use of drugs, using keywords in the title. Used 39 articles to write this systematic review. Results. The review examines the molecular mechanisms of autophagy and apoptosis involved in the progression of ovarian cancer and in the formation of resistance to anticancer drug therapy. It has been shown that modulation of autophagy and apoptosis can change the effectiveness of drug treatment for this tumor. Conclusion. Considering the literature data on the ambiguous role of autophagy and apoptosis in the course of ovarian cancer and the formation of resistance to antitumor treatment, further study is required and the search for new molecular targets for their modulation is required.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	обзор	ru_RU
dc.subject	эпителиальный рак яичников	ru_RU
dc.subject	аутофагия	ru_RU
dc.subject	апоптоз	ru_RU
dc.subject	препараты платины	ru_RU
dc.subject	химиорезистентность ХИМИОРЕЗИСТЕНТНОСТЬ	ru_RU
dc.title	Влияние некоторых белков аутофагии (LC3b и Beclin1) и апоптоза (Casp8 и Bcl2) на клиническое течение рака яичников	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU