KFU. Card publication. Role of A2-adrenoceptors in Rat Heart with the Model of myocardial Infarction

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FEDERAL UNIVERSITY

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ROLE OF A2-ADRENOCEPTORS IN RAT HEART WITH THE MODEL OF MYOCARDIAL INFARCTION

Form of presentation

Articles in international journals and collections

Year of publication

2021

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Authors, employees of KFU

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Kupcova Anna Mikhaylovna, author

Khabibrakhmanov Insaf Ilkhamovich, author

Authors, postgraduates KFU

Bugrov Roman Kutdusovich, postgraduate kfu

Kobzarev Roman Sergeevich, postgraduate kfu

Bibliographic description in the original language

Kuptsova A.M. Role of A2-adrenoceptors in Rat Heart with the Model of myocardial Infarction / A.M. Kuptsova, R.K. Bugrov, I.I. Khabibrakhmanov, R.S. Kobzarev, N.I. Ziyatdinova, T.L. Zefirov // Journal of Chemical Health Risks. 2021. - Vol. 11(2). pp. 129-134

Annotation

Chronic adrenergic and angiotensin-energic stimulation of the heart muscle is one of the main causes of the onset and development of heart failure. α2-AR is widespread in the cardiovascular system and can be further applied and introduced into the heart's regenerative cell therapy. This study's objective was to study the effect of α2-AR stimulation on the performance of an isolated heart in rats with a model of myocardial infarction. To study the mechanisms of MI, experiments were carried out according to the classical technique of H. Selye - ligation of the anterior branch of the left coronary artery and perfusion of a Langendorff heart with a model of myocardial infarction. We studied the parameters of myocardial activity by changes in heart rate, as well as the left ventricle pressure (LVP), and the CF (dp/dtmax)/(dp/dtmin) of the left ventricle. Coronary dilator activity was assessed by measuring the outflow of the perfusion solution through the coronary arteries. The amplitude of the left ventricle's pressure wave after application of the α2-AR agonist clonidine hydrochloride at a concentration of 10-6 M to the perfused solution increased by 44% (p≤0.05) from the initial values. The rate of contraction and the rate of relaxation of the left ventricular myocardium also increased by 20% (p≤0.05) and 37% (p≤0.05), respectively. The activation of α2-AR in adult rats' isolated hearts with a model of myocardial infarction caused a decrease in heart rate by 18% (p≤0.05) and CF by 2% (p≤0.05).

Keywords

Model Myocardial infarction; α2-adrenoreceptors; Isolated heart; Rat

The name of the journal

Journal of Chemical Health Risks

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=253398&p_lang=2

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Full metadata record

Field DC	Value	Language
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Kupcova Anna Mikhaylovna	ru_RU
dc.contributor.author	Khabibrakhmanov Insaf Ilkhamovich	ru_RU
dc.contributor.author	Bugrov Roman Kutdusovich	ru_RU
dc.contributor.author	Kobzarev Roman Sergeevich	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Kuptsova A.M. Role of A2-adrenoceptors in Rat Heart with the Model of myocardial Infarction / A.M. Kuptsova, R.K. Bugrov, I.I. Khabibrakhmanov, R.S. Kobzarev, N.I. Ziyatdinova, T.L. Zefirov // Journal of Chemical Health Risks. 2021. - Vol. 11(2). pp. 129-134	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=253398&p_lang=2	ru_RU
dc.description.abstract	Journal of Chemical Health Risks	ru_RU
dc.description.abstract	Chronic adrenergic and angiotensin-energic stimulation of the heart muscle is one of the main causes of the onset and development of heart failure. α2-AR is widespread in the cardiovascular system and can be further applied and introduced into the heart's regenerative cell therapy. This study's objective was to study the effect of α2-AR stimulation on the performance of an isolated heart in rats with a model of myocardial infarction. To study the mechanisms of MI, experiments were carried out according to the classical technique of H. Selye - ligation of the anterior branch of the left coronary artery and perfusion of a Langendorff heart with a model of myocardial infarction. We studied the parameters of myocardial activity by changes in heart rate, as well as the left ventricle pressure (LVP), and the CF (dp/dtmax)/(dp/dtmin) of the left ventricle. Coronary dilator activity was assessed by measuring the outflow of the perfusion solution through the coronary arteries. The amplitude of the left ventricle's pressure wave after application of the α2-AR agonist clonidine hydrochloride at a concentration of 10-6 M to the perfused solution increased by 44% (p≤0.05) from the initial values. The rate of contraction and the rate of relaxation of the left ventricular myocardium also increased by 20% (p≤0.05) and 37% (p≤0.05), respectively. The activation of α2-AR in adult rats' isolated hearts with a model of myocardial infarction caused a decrease in heart rate by 18% (p≤0.05) and CF by 2% (p≤0.05).	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Role of A2-adrenoceptors in Rat Heart with the Model of myocardial Infarction	ru_RU
dc.type	Articles in international journals and collections	ru_RU