KFU. Card publication. Effect of α2-Adrenoreceptors stimulation after blockade of the current activated by hyperpolarization, if, in 6-week-old rat's isolated heart

- RUS
- 中文
- ES

EFFECT OF α2-ADRENORECEPTORS STIMULATION AFTER BLOCKADE OF THE CURRENT ACTIVATED BY HYPERPOLARIZATION, IF, IN 6-WEEK-OLD RAT'S ISOLATED HEART

Form of presentation

Articles in international journals and collections

Year of publication

2020

��

��

Authors, employees of KFU

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Kupcova Anna Mikhaylovna, author

Leonova Alina Maratovna, author

Authors, postgraduates KFU

Leonova Alina Maratovna, postgraduate kfu

Miller Arnold Geynrikhovich, postgraduate kfu

Bibliographic description in the original language

Kuptsova A.M. Effect of α2-Adrenoreceptors stimulation after blockade of the current activated by hyperpolarization, if, in 6-week-old rat's isolated heart / A.M. Kuptsova, A.M. Galieva, A.G. Miller, N.I. Ziyatdinova, T.L. Zefirov // Archivos Venezolanos de Farmacología y Terapéutica. 2020. - Vol. 39, N.7. - pp.826-830.

Annotation

Adrenergic receptors agonists are widely used to treat car- diovascular diseases. All 3 subtypes of α2-adrenergic recep- tors (α2-AR) have been found in the human heart using the polymerase chain reaction. Radioligand test and immunob- lotting revealed α2-AR in the myocardium of normotensive and also spontaneously hypertensive rats. The evidence demonstrated the interaction of α2-AR and If in the relief of mechanical and thermal pain. The α2-AR agonist, clonidine, by inhibiting HCN channels, causes a strong bradycardic ef- fect. The objective of this research is to study the effect of the activation of α2-AR in the presence of the blockade of If with ZD7288, on the parameters of the isolated rat heart after the formation of adrenergic regulation of the heart. Experi- ments on isolated hearts were performed ex vivo, using the Langendorff-isolated heart preparation. During the study, the coronary flow (CF), heart rate (HR), pressure wave amplitude (PWA), maximum wave rise rate (dP/dtmax), maximum wave drop rate (dP/dtmin) were studied. The findings demonstrate a role of α2-AR and If in the adrenergic regulation mechanisms of the function of an isolated heart of 6-week-old rats, since they showed that the blockade of If with ZD7288, caused an increase in heart inotropy, as well as multidirectional effects on the rhythm and blood flow of the isolated rat heart after the formation of adrenergic innervation.

Keywords

α2-adrenoreceptors, If-currents, isolated heart, rat.

The name of the journal

Archivos Venezolanos de Farmacología y Terapéutica

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=253700&p_lang=2

Resource files

File name	Size (MB)	Format
F_KAM_Effect_of___945_2_adrenoreceptors_stimulation.pdf	0,35	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Kupcova Anna Mikhaylovna	ru_RU
dc.contributor.author	Leonova Alina Maratovna	ru_RU
dc.contributor.author	Leonova Alina Maratovna	ru_RU
dc.contributor.author	Miller Arnold Geynrikhovich	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Kuptsova A.M. Effect of α2-Adrenoreceptors stimulation after blockade of the current activated by hyperpolarization, if, in 6-week-old rat's isolated heart / A.M. Kuptsova, A.M. Galieva, A.G. Miller, N.I. Ziyatdinova, T.L. Zefirov // Archivos Venezolanos de Farmacología y Terapéutica. 2020. - Vol. 39, N.7. - pp.826-830.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=253700&p_lang=2	ru_RU
dc.description.abstract	Archivos Venezolanos de Farmacología y Terapéutica	ru_RU
dc.description.abstract	Adrenergic receptors agonists are widely used to treat car- diovascular diseases. All 3 subtypes of α2-adrenergic recep- tors (α2-AR) have been found in the human heart using the polymerase chain reaction. Radioligand test and immunob- lotting revealed α2-AR in the myocardium of normotensive and also spontaneously hypertensive rats. The evidence demonstrated the interaction of α2-AR and If in the relief of mechanical and thermal pain. The α2-AR agonist, clonidine, by inhibiting HCN channels, causes a strong bradycardic ef- fect. The objective of this research is to study the effect of the activation of α2-AR in the presence of the blockade of If with ZD7288, on the parameters of the isolated rat heart after the formation of adrenergic regulation of the heart. Experi- ments on isolated hearts were performed ex vivo, using the Langendorff-isolated heart preparation. During the study, the coronary flow (CF), heart rate (HR), pressure wave amplitude (PWA), maximum wave rise rate (dP/dtmax), maximum wave drop rate (dP/dtmin) were studied. The findings demonstrate a role of α2-AR and If in the adrenergic regulation mechanisms of the function of an isolated heart of 6-week-old rats, since they showed that the blockade of If with ZD7288, caused an increase in heart inotropy, as well as multidirectional effects on the rhythm and blood flow of the isolated rat heart after the formation of adrenergic innervation.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	α2-adrenoreceptors	ru_RU
dc.subject	If-currents	ru_RU
dc.subject	isolated heart	ru_RU
dc.subject	rat.	ru_RU
dc.title	Effect of α2-Adrenoreceptors stimulation after blockade of the current activated by hyperpolarization, if, in 6-week-old rat's isolated heart	ru_RU
dc.type	Articles in international journals and collections	ru_RU