KFU. Card publication. Rational Design 2-Hydroxypropylphosphonium Salts as Cancer Cell Mitochondria-Targeted Vectors: Synthesis, Structure, and Biological Properties

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RATIONAL DESIGN 2-HYDROXYPROPYLPHOSPHONIUM SALTS AS CANCER CELL MITOCHONDRIA-TARGETED VECTORS: SYNTHESIS, STRUCTURE, AND BIOLOGICAL PROPERTIES

Form of presentation

Articles in international journals and collections

Year of publication

2021

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Authors, employees of KFU

Titov Evgeniy Andreevich, author

Bibliographic description in the original language

Rational Design 2-Hydroxypropylphosphonium Salts as Cancer Cell Mitochondria-Targeted Vectors: Synthesis, Structure, and Biological Properties / Mironov V.F., Nemtarev A.V., Tsepaeva O.V., Dimukhametov M.N., Litvinov I.A., Voloshina A.D., Pashirova T.N., Titov E.A., Lyubina A.P., Amerhanova S.K., Gubaidullin A.T., Islamov D.R. // Molecules. MDPI AG - 2021. - V. 26, N. 21, P. 6350

Annotation

Molecules

Keywords

phosphonium salt; P?C bond formation; oxirane; glycidyl ether; triphenylphosphine; addition reaction; nucleophilic substitution

The name of the journal

Molecules

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=257826&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Titov Evgeniy Andreevich	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Rational Design 2-Hydroxypropylphosphonium Salts as Cancer Cell Mitochondria-Targeted Vectors: Synthesis, Structure, and Biological Properties / Mironov V.F., Nemtarev A.V., Tsepaeva O.V., Dimukhametov M.N., Litvinov I.A., Voloshina A.D., Pashirova T.N., Titov E.A., Lyubina A.P., Amerhanova S.K., Gubaidullin A.T., Islamov D.R. // Molecules. MDPI AG - 2021. - V. 26, N. 21, P. 6350	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=257826&p_lang=2	ru_RU
dc.description.abstract	Molecules	ru_RU
dc.description.abstract	It has been shown for a wide range of epoxy compounds that their interaction with tri- phenylphosphonium triflate occurs with a high chemoselectivity and leads to the formation of (2- hydroxypropyl)triphenylphosphonium triflates 3 substituted in the 3-position with an alkoxy, al- kylcarboxyl group, or halogen, which were isolated in a high yield. Using the methodology for the disclosure of epichlorohydrin with alcohols in the presence of boron trifluoride etherate, followed by the substitution of iodine for chlorine and treatment with triphenylphosphine, 2-hydroxypro- pyltriphenylphosphonium iodides 4 were also obtained. The molecular and supramolecular struc- ture of the obtained phosphonium salts was established, and their high antitumor activity was re- vealed in relation to duodenal adenocarcinoma. The formation of liposomal systems based on phos- phonium salt 3 and L-α-phosphatidylcholine (PC) was employed for improving the bioavailability and reducing the toxicity. They were produced by the thin film rehydration method and exhibited cytotoxic properties. This rational design of phosphonium salts 3 and 4 has promising potential of new vectors for targeted delivery into mitochondria of tumor cells	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Rational Design 2-Hydroxypropylphosphonium Salts as Cancer Cell Mitochondria-Targeted Vectors: Synthesis, Structure, and Biological Properties	ru_RU
dc.type	Articles in international journals and collections	ru_RU