| Form of presentation | Articles in Russian journals and collections |
| Year of publication | 2019 |
| Язык | английский |
|
Khaziev Rail Maratovich, author
|
| Bibliographic description in the original language |
Khaziev, R. Synthesis and antimicrobial activity of adamantyl substituted pyridoxine derivatives / R. Khaziev, N. Shtyrlin, R. Pavelyev, R. Nigmatullin, R. Gabbasova, D. Grishaev, A. Shtro, A. Galochkina, Y. Nikolaeva, T. Vinogradova, O. Manicheva, M. Dogonadze, O. Gnezdilov, E. Sokolovich, P. Yablonskiy, K. Balakin, Yu. Shtyrlin // Letters in Drug Design & Discovery. – 2019. – V. 16, N. 2. – P. 1360-1369 |
| Annotation |
Adamantane derivatives possess multiple pharmacological activities such
as antiviral, anticancer, antimycobacterial, antidiabetic, antiparkinsonian and others. The interest of
medicinal chemists in adamantane compounds is due to their unique spatial structure, high lipophilicity,
and carbon cage rigidity. As a result, these molecules can easily penetrate biological lipid
membranes and often have unique target-specific activity profile. Another pharmacophore studied in
this work is pyridoxine (vitamin B6). Pyridoxine plays highly important roles in living cells as a key
cofactor of many enzymes. On the other hand, its molecular scaffold is a valuable structural platform
which has led to the development of several launched drugs (Pyritinol, Pirisudanol, Cycletanine,
Mangafodipir) and a wide number of preclinical and clinical drug candidates |
| Keywords |
Pyridoxine, adamantane derivatives, antimycobacterial activity, antiviral activity, M. tuberculosis, dipharmacophore
molecules |
| The name of the journal |
LETTERS IN DRUG DESIGN & DISCOVERY
|
| Please use this ID to quote from or refer to the card |
https://repository.kpfu.ru/eng/?p_id=257993&p_lang=2 |
Full metadata record  |
| Field DC |
Value |
Language |
| dc.contributor.author |
Khaziev Rail Maratovich |
ru_RU |
| dc.date.accessioned |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2019 |
ru_RU |
| dc.identifier.citation |
Khaziev, R. Synthesis and antimicrobial activity of adamantyl substituted pyridoxine derivatives / R. Khaziev, N. Shtyrlin, R. Pavelyev, R. Nigmatullin, R. Gabbasova, D. Grishaev, A. Shtro, A. Galochkina, Y. Nikolaeva, T. Vinogradova, O. Manicheva, M. Dogonadze, O. Gnezdilov, E. Sokolovich, P. Yablonskiy, K. Balakin, Yu. Shtyrlin // Letters in Drug Design & Discovery. – 2019. – V. 16, N. 2. – P. 1360-1369 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/eng/?p_id=257993&p_lang=2 |
ru_RU |
| dc.description.abstract |
LETTERS IN DRUG DESIGN & DISCOVERY |
ru_RU |
| dc.description.abstract |
Adamantane derivatives possess multiple pharmacological activities such
as antiviral, anticancer, antimycobacterial, antidiabetic, antiparkinsonian and others. The interest of
medicinal chemists in adamantane compounds is due to their unique spatial structure, high lipophilicity,
and carbon cage rigidity. As a result, these molecules can easily penetrate biological lipid
membranes and often have unique target-specific activity profile. Another pharmacophore studied in
this work is pyridoxine (vitamin B6). Pyridoxine plays highly important roles in living cells as a key
cofactor of many enzymes. On the other hand, its molecular scaffold is a valuable structural platform
which has led to the development of several launched drugs (Pyritinol, Pirisudanol, Cycletanine,
Mangafodipir) and a wide number of preclinical and clinical drug candidates |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Pyridoxine |
ru_RU |
| dc.subject |
adamantane derivatives |
ru_RU |
| dc.subject |
antimycobacterial activity |
ru_RU |
| dc.subject |
antiviral activity |
ru_RU |
| dc.subject |
M. tuberculosis |
ru_RU |
| dc.subject |
dipharmacophore
molecules |
ru_RU |
| dc.title |
Synthesis and antimicrobial activity of adamantyl substituted pyridoxine derivatives |
ru_RU |
| dc.type |
Articles in Russian journals and collections |
ru_RU |
|
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