KFU. Card publication. The Study of Cerebrospinal Fluid microRNAs in Spinal Cord Injury and Neurodegenerative Diseases: Methodological Problems and Possible Solutions

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THE STUDY OF CEREBROSPINAL FLUID MICRORNAS IN SPINAL CORD INJURY AND NEURODEGENERATIVE DISEASES: METHODOLOGICAL PROBLEMS AND POSSIBLE SOLUTIONS

Form of presentation

Articles in international journals and collections

Year of publication

2022

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Authors, employees of KFU

Baychurina Irina Alekseevna, author

Mukhamedshina Yana Olegovna, author

Rizvanov Albert Anatolevich, author

Other authors

James Victoria , author

Valiullin Viktor Vladimirovich, author

Bibliographic description in the original language

Baichurina I. et al. The Study of Cerebrospinal Fluid microRNAs in Spinal Cord Injury and Neurodegenerative Diseases: Methodological Problems and Possible Solutions/ I. Baichurina ,V. Valiullin ,V. James ,A. Rizvanov,Y. Mukhamedshina //International journal of molecular sciences; 2022. – T. 23. – �. 1. – S. 114.

Annotation

International journal of molecular sciences

Keywords

neurological disorders; spinal cord injury; neurodegenerative diseases; miRNA; cerebrospinal fluid; biomarkers

The name of the journal

International journal of molecular sciences

On-line resource for training course

http://dspace.kpfu.ru/xmlui/bitstream/handle/net/166602/F_ijms_23_00114_v2.pdf?sequence=1&isAllowed=y

URL

https://www.mdpi.com/1422-0067/23/1/114

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=261957&p_lang=2

Resource files

File name	Size (MB)	Format
F_ijms_23_00114_v2.pdf	0,65	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Baychurina Irina Alekseevna	ru_RU
dc.contributor.author	Mukhamedshina Yana Olegovna	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	James Victoria	ru_RU
dc.contributor.author	Valiullin Viktor Vladimirovich	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Baichurina I. et al. The Study of Cerebrospinal Fluid microRNAs in Spinal Cord Injury and Neurodegenerative Diseases: Methodological Problems and Possible Solutions/ I. Baichurina ,V. Valiullin ,V. James ,A. Rizvanov,Y. Mukhamedshina //International journal of molecular sciences; 2022. – �. 23. – �. 1. – �. 114.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=261957&p_lang=2	ru_RU
dc.description.abstract	International journal of molecular sciences	ru_RU
dc.description.abstract	Despite extensive research on neurological disorders, unanswered questions remain regarding the molecular mechanisms underpinning the course of these diseases, and the search continues for effective biomarkers for early diagnosis, prognosis, or therapeutic intervention. These questions are especially acute in the study of spinal cord injury (SCI) and neurodegenerative diseases. It is believed that the changes in gene expression associated with processes triggered by neurological disorders are the result of post-transcriptional gene regulation. microRNAs (miRNAs) are key regulators of post-transcriptional gene expression and, as such, are often looked to in the search for effective biomarkers. We propose that cerebrospinal fluid (CSF) is potentially a source of biomarkers since it is in direct contact with the central nervous system and therefore may contain biomarkers indicating neurodegeneration or damage to the brain and spinal cord. However, since the abundance of miRNAs in CSF is low, their isolation and detection is technically difficult. In this review, we evaluate the findings of recent studies of CSF miRNAs as biomarkers of spinal cord injury (SCI) and neurodegenerative diseases. We also summarize the current knowledge concerning the methods of studying miRNA in CSF, including RNA isolation and normalization of the data, highlighting the caveats of these approaches and possible solutions.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	The Study of Cerebrospinal Fluid microRNAs in Spinal Cord Injury and Neurodegenerative Diseases: Methodological Problems and Possible Solutions	ru_RU
dc.type	Articles in international journals and collections	ru_RU