KFU. Card publication. Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage

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INCREASING SEVERITY OF SPINAL CORD INJURY RESULTS IN MICROGLIA/MACROPHAGES WITH ANNULAR-SHAPED MORPHOLOGY AND NO CHANGE IN EXPRESSION OF CD40 AND TUMOR GROWTH FACTOR-β DURING THE CHRONIC POST-INJURY STAGE

Form of presentation

Articles in international journals and collections

Year of publication

2022

Authors, employees of KFU

Arkhipova Svetlana Sergeevna, author

Rizvanov Albert Anatolevich, author

Rogozhin Aleksandr Aleksandrovich, author

Other authors

Victoria James

Authors, postgraduates KFU

Akhmetzyanova Elvira Ruslanovna, postgraduate kfu

Kostennikov Aleksandr Aleksandrovich, postgraduate kfu

Sabirov Davran Khudayshukurovich, postgraduate kfu

Bibliographic description in the original language

Akhmetzyanova E.R, Timofeeva A.V, Sabirov D.K, Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage//Frontiers in Molecular Neuroscience. - 2022. - Vol.14, Is.. - Art. �802558.

Annotation

Determination of the quantitative composition of phenotypically and morphologically different populations of resident microglia and infiltrating macrophages in spinal cord injury (SCI) of various degrees of severity could lead to much needed novel therapeutic interventions in neurotrauma. In this regard, we investigated the CD40 and TGF-β expressing populations of microglia/macrophages and their morphological states in a rat model of SCI of varying severity. We are the first to describe the annular-shaped microglia/macrophages, the morphology of which was formed due to the spatial orientation of the processes that form round or oval micro-territories, which include disintegrating myelin fibers. This type of cell morphology was found only in the injured spinal cord and mainly in the white matter. At the same time, an assessment of the number of annular-shaped microglia/macrophages and the diameter of micro-territories formed by their processes showed an elevation in these indicators as

Keywords

spinal cord injury, microglia, rat, polarization, morphology

The name of the journal

Frontiers in Molecular Neuroscience

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=265444&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Arkhipova Svetlana Sergeevna	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Rogozhin Aleksandr Aleksandrovich	ru_RU
dc.contributor.author	Akhmetzyanova Elvira Ruslanovna	ru_RU
dc.contributor.author	Kostennikov Aleksandr Aleksandrovich	ru_RU
dc.contributor.author	Sabirov Davran Khudayshukurovich	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Akhmetzyanova E.R, Timofeeva A.V, Sabirov D.K, Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage//Frontiers in Molecular Neuroscience. - 2022. - Vol.14, Is.. - Art. �802558.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=265444&p_lang=2	ru_RU
dc.description.abstract	Frontiers in Molecular Neuroscience	ru_RU
dc.description.abstract	Determination of the quantitative composition of phenotypically and morphologically different populations of resident microglia and infiltrating macrophages in spinal cord injury (SCI) of various degrees of severity could lead to much needed novel therapeutic interventions in neurotrauma. In this regard, we investigated the CD40 and TGF-β expressing populations of microglia/macrophages and their morphological states in a rat model of SCI of varying severity. We are the first to describe the annular-shaped microglia/macrophages, the morphology of which was formed due to the spatial orientation of the processes that form round or oval micro-territories, which include disintegrating myelin fibers. This type of cell morphology was found only in the injured spinal cord and mainly in the white matter. At the same time, an assessment of the number of annular-shaped microglia/macrophages and the diameter of micro-territories formed by their processes showed an elevation in these indicators as	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	spinal cord injury	ru_RU
dc.subject	microglia	ru_RU
dc.subject	rat	ru_RU
dc.subject	polarization	ru_RU
dc.subject	morphology	ru_RU
dc.title	Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage	ru_RU
dc.type	Articles in international journals and collections	ru_RU