KFU. Card publication. Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid

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DESIGN, SPECTRAL CHARACTERISTICS, PHOTOSTABILITY, AND POSSIBILITIES FOR PRACTICAL APPLICATION OF BODIPY FL-LABELED THIOTERPENOID

Form of presentation

Articles in international journals and collections

Year of publication

2022

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Authors, employees of KFU

Pavelev Roman Sergeevich, author

Bibliographic description in the original language

Guseva, G.B. Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid / G.B. Guseva, E.V. Antina, M.B. Berezin, A.S. Smirnova, R.S. Pavelyev, I.R. Gilfanov, O.G. Shevchenko, S.V. Pestova, E.S. Izmest'ev, S.A. Rubtsova, O.V. Ostolopovskaya, S.V. Efimov, V.V. Klochkov, I.Z. Rakhmatullin, A.F. Timerova, I.A. Khodov, O.A. Lodochnikova, D.R. Islamov, P.V. Dorovatovskii, L.E. Nikitina, S.V. Boichuk // Bioengineering, 2022, 9, 210.

Annotation

Bioengineering

Keywords

fluorescent biomarker; BODIPY dyes; thioterpenoid; erythrocytes; spectral properties; membranotropic effect

The name of the journal

Bioengineering

URL

https://www.mdpi.com/2306-5354/9/5/210/htm

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=268761&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Pavelev Roman Sergeevich	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Guseva, G.B. Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid / G.B. Guseva, E.V. Antina, M.B. Berezin, A.S. Smirnova, R.S. Pavelyev, I.R. Gilfanov, O.G. Shevchenko, S.V. Pestova, E.S. Izmest'ev, S.A. Rubtsova, O.V. Ostolopovskaya, S.V. Efimov, V.V. Klochkov, I.Z. Rakhmatullin, A.F. Timerova, I.A. Khodov, O.A. Lodochnikova, D.R. Islamov, P.V. Dorovatovskii, L.E. Nikitina, S.V. Boichuk // Bioengineering, 2022, 9, 210.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=268761&p_lang=2	ru_RU
dc.description.abstract	Bioengineering	ru_RU
dc.description.abstract	This paper presents the design and a comparative analysis of the structural and solvation factors on the spectral and biological properties of the BODIPY biomarker with a thioterpene fragment. Covalent binding of the thioterpene moiety to the butanoic acid residue of meso-substituted BODIPY was carried out to find out the membranotropic effect of conjugate to erythrocytes, and to assess the possibilities of its practical application in bioimaging. The molecular structure of the conjugate was confirmed via X-ray, UV/vis-, NMR-, and MS-spectra. It was found that dye demonstrates high photostability and high fluorescence quantum yield (to ~100%) at 514–519 nm. In addition, the marker was shown to effectively penetrate the erythrocytes membrane in the absence of erythrotoxicity. The conjugation of BODIPY with thioterpenoid is an excellent way to increase affinity dyes to biostructures, including blood components.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid	ru_RU
dc.type	Articles in international journals and collections	ru_RU