KFU. Card publication. Postnatal development of the microstructure of cortical GABAergic synapses and perineuronal nets requires sensory input

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FEDERAL UNIVERSITY

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POSTNATAL DEVELOPMENT OF THE MICROSTRUCTURE OF CORTICAL GABAERGIC SYNAPSES AND PERINEURONAL NETS REQUIRES SENSORY INPUT

Form of presentation

Articles in international journals and collections

Year of publication

2022

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Authors, employees of KFU

Aganov Albert Vartanovich, author

Arnst Nikita Igorevich, author

Kiyasov Andrey Pavlovich, author

Kochneva Anastasiya Anatolevna, author

Melnikova Anastasiya Aleksandrovna, author

Osin Yuriy Nikolaevich, author

Titova Angelina Andreevna, author

Fedosimova Svetlana Vladimirovna, author

Shaykhutdinov Nurislam Maratovich, author

Other authors

Pavelev Mikhail , author

Authors, postgraduates KFU

Lipachev Nikita Sergeevich, postgraduate kfu

Authors, students KFU

Dvoeglazova Anastasiya Sergeevna, author

Bibliographic description in the original language

Lipachev, N. Postnatal development of the microstructure of cortical GABAergic synapses and perineuronal nets requires sensory input / N. Lipachev, A. Melnikova, S. Kuznetsova, N. Arnst, A. Kochneva, N. Shaikhutdinov, A. Dvoeglazova, A. Titova, M. Mavlikeev, A.V. Aganov, Yu.N. Osin, A.P. Kiyasov, M. Paveliev // Neuroscience Research. – 2022. – V.182. – P. 32–40

Annotation

The brain synaptic circuitry is formed as a result of pre-defined genetic programs and sensory experience during postnatal development. Perineuronal nets ensheath synaptic boutons and control several crucial features of the synapse physiology. Formation of the perineuronal net microstructure during the brain development remains largely unstudied. Here we provide a detailed quantitative description of the 3-dimensional geometry of the synapse and the surrounding perineuronal net in the mouse somatosensory cortex layer IV. We compare the morphology of the synapse+perineuronal net complex in the adult brain formed under normal conditions or in the whisker shaving model of somatosensory deprivation. We demonstrate that the sensory deprivation causes flattening of the 3D PNN mesh geometry and reduction of the VGAT-positive cluster volume in presynaptic boutons. These results reveal a mechanism of the sensory input-dependent synapse morphogenesis during the brain development.

Keywords

Perineuronal nets, GABAergic synapses, Postnatal development, Quantitative analysis

The name of the journal

NEUROSCIENCE

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=273329&p_lang=2

Resource files

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Lipachev_N.___Neuroscience_Research_2022___Postnatal_development_of_the_microstructure_of_cortical_GABAergic.pdf	8,21	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Aganov Albert Vartanovich	ru_RU
dc.contributor.author	Arnst Nikita Igorevich	ru_RU
dc.contributor.author	Kiyasov Andrey Pavlovich	ru_RU
dc.contributor.author	Kochneva Anastasiya Anatolevna	ru_RU
dc.contributor.author	Melnikova Anastasiya Aleksandrovna	ru_RU
dc.contributor.author	Osin Yuriy Nikolaevich	ru_RU
dc.contributor.author	Titova Angelina Andreevna	ru_RU
dc.contributor.author	Fedosimova Svetlana Vladimirovna	ru_RU
dc.contributor.author	Shaykhutdinov Nurislam Maratovich	ru_RU
dc.contributor.author	Pavelev Mikhail	ru_RU
dc.contributor.author	Dvoeglazova Anastasiya Sergeevna	ru_RU
dc.contributor.author	Lipachev Nikita Sergeevich	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Lipachev, N. Postnatal development of the microstructure of cortical GABAergic synapses and perineuronal nets requires sensory input / N. Lipachev, A. Melnikova, S. Kuznetsova, N. Arnst, A. Kochneva, N. Shaikhutdinov, A. Dvoeglazova, A. Titova, M. Mavlikeev, A.V. Aganov, Yu.N. Osin, A.P. Kiyasov, M. Paveliev // Neuroscience Research. – 2022. – V.182. – P. 32–40	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=273329&p_lang=2	ru_RU
dc.description.abstract	NEUROSCIENCE	ru_RU
dc.description.abstract	The brain synaptic circuitry is formed as a result of pre-defined genetic programs and sensory experience during postnatal development. Perineuronal nets ensheath synaptic boutons and control several crucial features of the synapse physiology. Formation of the perineuronal net microstructure during the brain development remains largely unstudied. Here we provide a detailed quantitative description of the 3-dimensional geometry of the synapse and the surrounding perineuronal net in the mouse somatosensory cortex layer IV. We compare the morphology of the synapse+perineuronal net complex in the adult brain formed under normal conditions or in the whisker shaving model of somatosensory deprivation. We demonstrate that the sensory deprivation causes flattening of the 3D PNN mesh geometry and reduction of the VGAT-positive cluster volume in presynaptic boutons. These results reveal a mechanism of the sensory input-dependent synapse morphogenesis during the brain development.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Perineuronal nets	ru_RU
dc.subject	GABAergic synapses	ru_RU
dc.subject	Postnatal development	ru_RU
dc.subject	Quantitative analysis	ru_RU
dc.title	Postnatal development of the microstructure of cortical GABAergic synapses and perineuronal nets requires sensory input	ru_RU
dc.type	Articles in international journals and collections	ru_RU