KFU. Card publication. Competing Role of Water in Inclusion of Indomethacin and Volatile Organic Compounds by Native Cyclodextrins

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FEDERAL UNIVERSITY

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COMPETING ROLE OF WATER IN INCLUSION OF INDOMETHACIN AND VOLATILE ORGANIC COMPOUNDS BY NATIVE CYCLODEXTRINS

Form of presentation

Articles in Russian journals and collections

Year of publication

2022

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Authors, employees of KFU

Gatiatulin Askar Kamilevich, author

Gorbachuk Valeriy Vilenovich, author

Ziganshin Marat Akhmedovich, author

Klimovickiy Aleksandr Evgenevich, author

Oselskaya Viktoriya Yurevna, author

Bibliographic description in the original language

Osel'skaya, V. Yu. Competing Role of Water in Inclusion of Indomethacin and Volatile Organic Compounds by Native Cyclodextrins/ V. Yu. Osel'skaya, A. K. Gatiatulin, A. E. Klimovitskii, M. A. Ziganshin, V. V. Gorbatchuk //Macroheterocycles. - 2022. –V.15, N3. – P.174-185. – DOI: 10.6060/mhc224319g.

Annotation

The hydration was found to reduce an efficiency of drug encapsulation by native cyclodextrins (CDs) when water is added above a certain threshold level. The hydration water competes with indomethacin for solid-phase inclusion in γ-cyclodextrin (γCD) and β-cyclodextrin (βCD) with an increase of water contents to the saturation level. No competing effect was observed for α-cyclodextrin (αCD) with this drug. The hydration effect for indomethacin correlates with the influence of hydration water on inclusion of volatile organic guests by native CDs. For these guests and γCD, the competing hydration effect was estimated also by determination of vapor sorption isotherms and was found higher than that for βCD but in most cases lower than such effect for αCD. The inclusion affinity and capacity of dried γCD for water and organic guests were determined and a significant size exclusion effect was observed, which contributes to the water-guest competition. The ratio between competing and activation roles of water for the studied three native cyclodextrins correlates with the parameters of their unit cells in hydrates and in dried state.

Keywords

γ-cyclodextrin, β-cyclodextrin, α-cyclodextrin, indomethacin, inclusion compound, encapsulation

The name of the journal

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URL

http://mhc-isuct.ru/article/view/4319

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=275329&p_lang=2

Resource files

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M_C_2022.pdf	1,65	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gatiatulin Askar Kamilevich	ru_RU
dc.contributor.author	Gorbachuk Valeriy Vilenovich	ru_RU
dc.contributor.author	Ziganshin Marat Akhmedovich	ru_RU
dc.contributor.author	Klimovickiy Aleksandr Evgenevich	ru_RU
dc.contributor.author	Oselskaya Viktoriya Yurevna	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Osel'skaya, V. Yu. Competing Role of Water in Inclusion of Indomethacin and Volatile Organic Compounds by Native Cyclodextrins/ V. Yu. Osel'skaya, A. K. Gatiatulin, A. E. Klimovitskii, M. A. Ziganshin, V. V. Gorbatchuk //Macroheterocycles. - 2022. –V.15, N3. – P.174-185. – DOI: 10.6060/mhc224319g.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=275329&p_lang=2	ru_RU
dc.description.abstract	��	ru_RU
dc.description.abstract	The hydration was found to reduce an efficiency of drug encapsulation by native cyclodextrins (CDs) when water is added above a certain threshold level. The hydration water competes with indomethacin for solid-phase inclusion in γ-cyclodextrin (γCD) and β-cyclodextrin (βCD) with an increase of water contents to the saturation level. No competing effect was observed for α-cyclodextrin (αCD) with this drug. The hydration effect for indomethacin correlates with the influence of hydration water on inclusion of volatile organic guests by native CDs. For these guests and γCD, the competing hydration effect was estimated also by determination of vapor sorption isotherms and was found higher than that for βCD but in most cases lower than such effect for αCD. The inclusion affinity and capacity of dried γCD for water and organic guests were determined and a significant size exclusion effect was observed, which contributes to the water-guest competition. The ratio between competing and activation roles of water for the studied three native cyclodextrins correlates with the parameters of their unit cells in hydrates and in dried state.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	γ-cyclodextrin	ru_RU
dc.subject	β-cyclodextrin	ru_RU
dc.subject	α-cyclodextrin	ru_RU
dc.subject	indomethacin	ru_RU
dc.subject	inclusion compound	ru_RU
dc.subject	encapsulation	ru_RU
dc.title	Competing Role of Water in Inclusion of Indomethacin and Volatile Organic Compounds by Native Cyclodextrins	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU