KFU. Card publication. Microbiota of the Colonic Diverticula in the Complicated Form of Diverticulitis: A Case Report

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FEDERAL UNIVERSITY

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MICROBIOTA OF THE COLONIC DIVERTICULA IN THE COMPLICATED FORM OF DIVERTICULITIS: A CASE REPORT

Form of presentation

Articles in international journals and collections

Year of publication

2022

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Authors, employees of KFU

Yarullina Dina Rashidovna, author

Bibliographic description in the original language

Yarullina Dina, Pankratova Yuliia, Karaseva Olga, Grigoryeva T, Karpukhin O. Microbiota of the Colonic Diverticula in the Complicated Form of Diverticulitis: A Case Report//LIFE. - 2022. - Vol.12, Is.12. - Art. �2129.

Annotation

Intestinal microbiota appears to be implicated in the pathogenesis of diverticular disease. We present the case of a patient with diverticular colon disease complicated by a pelvic abscess. During the successful surgical treatment, two specimens were taken from the resected colon segment for the microbiota analysis: an inflamed and perforated diverticulum and a diverticulum without signs of inflammation. Culturing and 16S rRNA gene sequencing revealed significant changes in the microbial community structure and composition associated with the acute inflammation and perforation of the colonic diverticulum. The characteristics that are usually associated with the inflammatory process in the gut, namely reduced microbial diversity and richness, decreased Firmicutes-to-Bacteroidetes (F/B) ratio, depletion of butyrate-producing bacteria, and Enterobacteriaceae blooming, were more pronounced in the non-inflamed diverticulum rather than in the adjacent inflamed and perforated one. This is the first study of the intraluminal microbiota of the diverticular pockets, which is more relevant to the etiology of diverticular disease than mucosa-associated microbiota via biopsies and luminal microbiota via fecal samples.

Keywords

diverticulitis, inflamed diverticulum, non-inflamed diverticulum, microbiota

The name of the journal

Life

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=278456&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Yarullina Dina Rashidovna	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Yarullina Dina, Pankratova Yuliia, Karaseva Olga, Grigoryeva T, Karpukhin O. Microbiota of the Colonic Diverticula in the Complicated Form of Diverticulitis: A Case Report//LIFE. - 2022. - Vol.12, Is.12. - Art. �2129.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=278456&p_lang=2	ru_RU
dc.description.abstract	Life	ru_RU
dc.description.abstract	Intestinal microbiota appears to be implicated in the pathogenesis of diverticular disease. We present the case of a patient with diverticular colon disease complicated by a pelvic abscess. During the successful surgical treatment, two specimens were taken from the resected colon segment for the microbiota analysis: an inflamed and perforated diverticulum and a diverticulum without signs of inflammation. Culturing and 16S rRNA gene sequencing revealed significant changes in the microbial community structure and composition associated with the acute inflammation and perforation of the colonic diverticulum. The characteristics that are usually associated with the inflammatory process in the gut, namely reduced microbial diversity and richness, decreased Firmicutes-to-Bacteroidetes (F/B) ratio, depletion of butyrate-producing bacteria, and Enterobacteriaceae blooming, were more pronounced in the non-inflamed diverticulum rather than in the adjacent inflamed and perforated one. This is the first study of the intraluminal microbiota of the diverticular pockets, which is more relevant to the etiology of diverticular disease than mucosa-associated microbiota via biopsies and luminal microbiota via fecal samples.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	diverticulitis	ru_RU
dc.subject	inflamed diverticulum	ru_RU
dc.subject	non-inflamed diverticulum	ru_RU
dc.subject	microbiota	ru_RU
dc.title	Microbiota of the Colonic Diverticula in the Complicated Form of Diverticulitis: A Case Report	ru_RU
dc.type	Articles in international journals and collections	ru_RU