KFU. Card publication. The Role of Intercellular Signaling in the Regulation of Bacterial Adaptive Proliferation

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FEDERAL UNIVERSITY

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THE ROLE OF INTERCELLULAR SIGNALING IN THE REGULATION OF BACTERIAL ADAPTIVE PROLIFERATION

Form of presentation

Articles in international journals and collections

Year of publication

2023

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Authors, employees of KFU

Vorobev Vladimir Nikolaevich, author

Bibliographic description in the original language

Olga Petrova , Olga Parfirova , Natalia Gogoleva , Vladimir Vorob'ev , Yuri Gogolev and Vladimir Gorshkov. The Role of Intercellular Signaling in the Regulation of Bacterial Adaptive Proliferation//Int. J. Mol. Sci. 2023, 24, 7266

Annotation

International Journal of Molecular Sciences

Keywords

adaptive proliferation; intercellular communication; starvation stress; autoinducers; Pectobacterium atrosepticum; quorum sensing; cross-protection

The name of the journal

International Journal of Molecular Sciences

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=279362&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Vorobev Vladimir Nikolaevich	ru_RU
dc.date.accessioned	2023-01-01T00:00:00Z	ru_RU
dc.date.available	2023-01-01T00:00:00Z	ru_RU
dc.date.issued	2023	ru_RU
dc.identifier.citation	Olga Petrova , Olga Parfirova , Natalia Gogoleva , Vladimir Vorob'ev , Yuri Gogolev and Vladimir Gorshkov. The Role of Intercellular Signaling in the Regulation of Bacterial Adaptive Proliferation//Int. J. Mol. Sci. 2023, 24, 7266	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=279362&p_lang=2	ru_RU
dc.description.abstract	International Journal of Molecular Sciences	ru_RU
dc.description.abstract	Bacterial adaptation is regulated at the population level with the involvement of intercellular communication (quorum sensing). When the population density is insufficient for adaptation under starvation, bacteria can adjust it to a quorum level through cell divisions at the expense of endogenous resources. This phenomenon has been described for the phytopathogenic bacterium Pectobacterium atrosepticum (Pba), and it is called, in our study, adaptive proliferation. An important attribute of adaptive proliferation is its timely termination, which is necessary to prevent the waste of endogenous resources when the required level of population density is achieved. However, metabolites that provide the termination of adaptive proliferation remained unidentified. We tested the hypothesis of whether quorum sensing-related autoinducers prime the termination of adaptive proliferation and assessed whether adaptive proliferation is a common phenomenon in the bacterial world. We showed that both known Pba quorum sensing-related autoinducers act synergistically and mutually compensatory to provide the timely termination of adaptive proliferation and formation of cross-protection. We also demonstrated that adaptive proliferation is implemented by bacteria of many genera and that bacteria with similar quorum sensing-related autoinducers have similar signaling backgrounds that prime the termination of adaptive proliferation, enabling the collaborative regulation of this adaptive program in multispecies communities.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	The Role of Intercellular Signaling in the Regulation of Bacterial Adaptive Proliferation	ru_RU
dc.type	Articles in international journals and collections	ru_RU