KFU. Card publication. The synthesis and cytotoxic activity of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro[chromeno[3,4-c]pyrrolidine-1,11'-indeno[1,2-b]quinoxalines]

- RUS
- 中文
- ES

THE SYNTHESIS AND CYTOTOXIC ACTIVITY OF N-UNSUBSTITUTED 3-ARYL-4-(TRIFLUOROMETHYL)-4H-SPIRO[CHROMENO[3,4-C]PYRROLIDINE-1,11'-INDENO[1,2-B]QUINOXALINES]

Form of presentation

Articles in international journals and collections

Year of publication

2022

��

��

Authors, employees of KFU

Madzhidov Timur Ismailovich, author

Bibliographic description in the original language

Barkovskii S.V. The synthesis and cytotoxic activity of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro[chromeno[3,4-c]pyrrolidine-1,11'-indeno[1,2-b]quinoxalines] / Barkovskii S.V., Ulitko M.V., Barkov A.Yu., Kochnev I.A., Zimnitskiy N.S., Korotaev V.Yu., Sosnovskikh V.Ya., Stepanyuk R.A., Madzhidov T.I. // Chemistry of Heterocyclic Compounds. - 2022. - Vol. 58. - P. 462-472.

Annotation

Chemistry of Heterocyclic Compounds

Keywords

azomethine ylides, benzylamines, indeno[1,2-b]quinoxalin-11-one, 3-nitro-2-trifluoromethyl-2H-chromenes, spiro[chromeno- [3,4-c]pyrrolidine-1,11'-indeno[1,2-b]quinoxalines], cytotoxic activity, 1,3-dipolar cycloaddition, in silico modeling.

The name of the journal

Chemistry of Heterocyclic Compounds

URL

https://link.springer.com/article/10.1007/s10593-022-03113-7

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=281123&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Madzhidov Timur Ismailovich	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Barkovskii S.V. The synthesis and cytotoxic activity of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro[chromeno[3,4-c]pyrrolidine-1,11'-indeno[1,2-b]quinoxalines] / Barkovskii S.V., Ulitko M.V., Barkov A.Yu., Kochnev I.�., Zimnitskiy N.S., Korotaev V.Yu., Sosnovskikh V.Ya., Stepanyuk R.�., Madzhidov T.I. // Chemistry of Heterocyclic Compounds. - 2022. - Vol. 58. - P. 462-472.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=281123&p_lang=2	ru_RU
dc.description.abstract	Chemistry of Heterocyclic Compounds	ru_RU
dc.description.abstract	A method for a regio- and stereoselective synthesis of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro[chromeno[3,4-c]pyrrolidine- 1,11'-indeno[1,2-b]quinoxalines] in 52–85% yields based on the three-component reaction of 3-nitro-2-trifluoromethyl-2H-chromenes with azomethine ylides generated in situ from benzylamines and indeno[1,2-b]quinoxalin-11-one by heating under reflux in CH2Cl2 for 2 h in the presence of 0.1 equiv of pyrrolidine was developed. The resulting compounds exhibited moderate cytotoxic activity against HeLa human cervical carcinoma cells in the concentration range of 10–5–10–4 M.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	azomethine ylides	ru_RU
dc.subject	benzylamines	ru_RU
dc.subject	indeno[1	ru_RU
dc.subject	2-b]quinoxalin-11-one	ru_RU
dc.subject	3-nitro-2-trifluoromethyl-2H-chromenes	ru_RU
dc.subject	spiro[chromeno- [3	ru_RU
dc.subject	4-c]pyrrolidine-1	ru_RU
dc.subject	11'-indeno[1	ru_RU
dc.subject	2-b]quinoxalines]	ru_RU
dc.subject	cytotoxic activity	ru_RU
dc.subject	1	ru_RU
dc.subject	3-dipolar cycloaddition	ru_RU
dc.subject	in silico modeling.	ru_RU
dc.title	The synthesis and cytotoxic activity of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro[chromeno[3,4-c]pyrrolidine-1,11'-indeno[1,2-b]quinoxalines]	ru_RU
dc.type	Articles in international journals and collections	ru_RU