Kazan (Volga region) Federal University, KFU
KAZAN
FEDERAL UNIVERSITY
 
MORPHOFUNCTIONAL CHANGES IN THE SPINAL CORD OF RATS AFTER CONTUSION INJURY WITH LOCAL DELIVERY OF METHYLPREDNISOLONE IN COMBINATION WITH A COPOLYMER
Form of presentationArticles in international journals and collections
Year of publication2023
Языканглийский
  • Baltin Maksim Eduardovich, author
  • Baltina Tatyana Valerevna, author
  • Sabirova Diana Emilevna, author
  • Sachenkov Oskar Aleksandrovich, author
  • Chernova Olga Nikolaevna, author
  • Sabirova Diana Emilevna, postgraduate kfu
  • Bibliographic description in the original language Baltin, M.E. Morphofunctional Changes in the Spinal Cord of Rats after Contusion Injury with Local Delivery of Methylprednisolone in Combination with a Copolymer/M.E. Baltin, D.E.Sabirova, O.N.Chernova, T. V. Baltina, O. A. Sachenkov //Bull Exp Biol Med. - 2023. - Vol.174, No6. - P. 810–815.
    Annotation methylprednisolone in combination with a block copolymer after contusion spinal cord injury in rats. Histological analysis of the spinal cord showed that delivery of a complex of methylprednisolone with a block copolymer reduced the volume of white and gray matter lesions. An increase in the amplitude of the evoked response of the gastrocnemius muscle was observed during epidural stimulation of the spinal cord 6 h after the injury. The maximum amplitude of the muscle response was greater in the group with local delivery of the methylprednisolone complex with the polymer 72 h after the injury. The obtained results demonstrate the neuroprotective effect of the local administration of the complex and allow to make positive prognosis for the recovery of the sensorimotor functions in rats.
    Keywords spinal cord injury, methylprednisolone, trifunctional block copolymer, morphometric analysis, evoked muscle responses
    The name of the journal Bulletin of Experimental Biology and Medicine
    URL https://www.scopus.com/inward/record.uri?eid=2-s2.0-85158970172&doi=10.1007%2fs10517-023-05795-1&partnerID=40&md5=9cdd8b824646fc45dbc318d19a6593b9
    Please use this ID to quote from or refer to the card https://repository.kpfu.ru/eng/?p_id=281375&p_lang=2
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