KFU. Card publication. Response of Isolated Rat Heart to ?2-Adrenergic Receptor Stimulation after If Current Blockade in the Late Postinfarction Period

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RESPONSE OF ISOLATED RAT HEART TO ?2-ADRENERGIC RECEPTOR STIMULATION AFTER IF CURRENT BLOCKADE IN THE LATE POSTINFARCTION PERIOD

Form of presentation

Articles in international journals and collections

Year of publication

2022

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Authors, employees of KFU

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Kupcova Anna Mikhaylovna, author

Authors, postgraduates KFU

Bugrov Roman Kutdusovich, postgraduate kfu

Bibliographic description in the original language

Bugrov R.K. Response of Isolated Rat Heart to ?2-Adrenergic Receptor Stimulation after If Current Blockade in the Late Postinfarction Period /R.K. Bugrov , A.M. Kuptsova, N.I. Ziyatdinova, T.L. Zefirov // Bulletin of Experimental Biology and Medicine. - 2022. - Vol.174, Is.1. - P.22-25.

Annotation

We studied the effect of α2-adrenoreceptor activation after preliminary If-current blockade on the performance of the Langendorff-isolated rat heart 54 days after modeling myocardial infarction. Stimulation of α2-adrenoreceptors against the background of application of If blocker ZD7288 in concentrations of 10-9 and 10-5 M decreased myocardial inotropy in isolated rat hearts by 50 and 39% (p<0.05) and increased HR by 20 and 15% (p<0.05), respectively. Activation of α2-adrenoreceptors against the background of application of ZD7288 in a concentration of 10-9 and 10-5 M led to a decrease in the coronary flow in the isolated rat heart with the model of myocardial infarction by 21% (p<0.05) and 32% (p<0.05), respectively.

Keywords

If-currents; isolated heart; myocardial infarction model; rat; α2-adrenergic receptors.

The name of the journal

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URL

https://link.springer.com/article/10.1007/s10517-022-05640-x

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=289998&p_lang=2

Resource files

File name	Size (MB)	Format
F_BEBiM_2022_Response_of_Isolated_Rat__eart_to___945_2_Adrenergic_Receptor.pdf	0,42	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Kupcova Anna Mikhaylovna	ru_RU
dc.contributor.author	Bugrov Roman Kutdusovich	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Bugrov R.K. Response of Isolated Rat Heart to ?2-Adrenergic Receptor Stimulation after If Current Blockade in the Late Postinfarction Period /R.K. Bugrov , A.M. Kuptsova, N.I. Ziyatdinova, T.L. Zefirov // Bulletin of Experimental Biology and Medicine. - 2022. - Vol.174, Is.1. - P.22-25.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=289998&p_lang=2	ru_RU
dc.description.abstract	��	ru_RU
dc.description.abstract	We studied the effect of α2-adrenoreceptor activation after preliminary If-current blockade on the performance of the Langendorff-isolated rat heart 54 days after modeling myocardial infarction. Stimulation of α2-adrenoreceptors against the background of application of If blocker ZD7288 in concentrations of 10-9 and 10-5 M decreased myocardial inotropy in isolated rat hearts by 50 and 39% (p<0.05) and increased HR by 20 and 15% (p<0.05), respectively. Activation of α2-adrenoreceptors against the background of application of ZD7288 in a concentration of 10-9 and 10-5 M led to a decrease in the coronary flow in the isolated rat heart with the model of myocardial infarction by 21% (p<0.05) and 32% (p<0.05), respectively.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Response of Isolated Rat Heart to ?2-Adrenergic Receptor Stimulation after If Current Blockade in the Late Postinfarction Period	ru_RU
dc.type	Articles in international journals and collections	ru_RU