KFU. Card publication. Pacemaker currents are involved in the regulation of 3-weekold rat's atrial myocardial contractility

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FEDERAL UNIVERSITY

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PACEMAKER CURRENTS ARE INVOLVED IN THE REGULATION OF 3-WEEKOLD RAT'S ATRIAL MYOCARDIAL CONTRACTILITY

Form of presentation

Articles in international journals and collections

Year of publication

2023

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Authors, employees of KFU

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Kupcova Anna Mikhaylovna, author

Faskhutdinov Lenar Ilsurovich, author

Khisamieva Luiza Irekovna, author

Authors, postgraduates KFU

Shakirov Ranis Rishatovich, postgraduate kfu

Bibliographic description in the original language

Kuptsova A.M. Pacemaker currents are involved in the regulation of 3-weekold rat's atrial myocardial contractility /A.M. Kuptsova, L.I. Khisamieva, L.I. Faskhutdinov, R.R. Shakirov,N.I. Ziyatdinova, T.L. Zefirov // Biophysical Reviews. - 2023. - Vol. 15. - p. 1461-1462.

Annotation

Hyperpolarization-activated cyclic nucleotide-regulated channels (HCN4) are key membrane proteins involved in the initiation and regulation of heartbeat. The pacemaker cells in the sinoatrial node generate the electrical impulse that underlies the contraction of atrial and ventricular cardiomyocytes. HCN4 channels contribute to the control of resting membrane potential and rhythmic activity of excitable cells expressing these channels. In addition to abundant expression in the pacing and conduction system, the membrane of adult rat working myocardium cells is characterized by low levels of HCN channels. However, in the early embryonic stages, HCN4 channels is abundantly transcribed throughout the heart and makes an important role in ventricular myocyte automatism triggered by If. By birth, HCN4 channels transcription is suppressed in working-type cardiomyocytes and remains at low levels in the adult body, which prevents pathological remodeling of the heart.

Keywords

Pacemaker currents, 3-weekold rat?s, atrial myocardial contractility

The name of the journal

Biophysical Journal

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=290414&p_lang=2

Resource files

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F_Kupcova_biophysics_2023_37_38.pdf	0,37	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Kupcova Anna Mikhaylovna	ru_RU
dc.contributor.author	Faskhutdinov Lenar Ilsurovich	ru_RU
dc.contributor.author	Khisamieva Luiza Irekovna	ru_RU
dc.contributor.author	Shakirov Ranis Rishatovich	ru_RU
dc.date.accessioned	2023-01-01T00:00:00Z	ru_RU
dc.date.available	2023-01-01T00:00:00Z	ru_RU
dc.date.issued	2023	ru_RU
dc.identifier.citation	Kuptsova A.M. Pacemaker currents are involved in the regulation of 3-weekold rat's atrial myocardial contractility /A.M. Kuptsova, L.I. Khisamieva, L.I. Faskhutdinov, R.R. Shakirov,N.I. Ziyatdinova, T.L. Zefirov // Biophysical Reviews. - 2023. - Vol. 15. - p. 1461-1462.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=290414&p_lang=2	ru_RU
dc.description.abstract	Biophysical Journal	ru_RU
dc.description.abstract	Hyperpolarization-activated cyclic nucleotide-regulated channels (HCN4) are key membrane proteins involved in the initiation and regulation of heartbeat. The pacemaker cells in the sinoatrial node generate the electrical impulse that underlies the contraction of atrial and ventricular cardiomyocytes. HCN4 channels contribute to the control of resting membrane potential and rhythmic activity of excitable cells expressing these channels. In addition to abundant expression in the pacing and conduction system, the membrane of adult rat working myocardium cells is characterized by low levels of HCN channels. However, in the early embryonic stages, HCN4 channels is abundantly transcribed throughout the heart and makes an important role in ventricular myocyte automatism triggered by If. By birth, HCN4 channels transcription is suppressed in working-type cardiomyocytes and remains at low levels in the adult body, which prevents pathological remodeling of the heart.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Pacemaker currents	ru_RU
dc.subject	3-weekold rat?s	ru_RU
dc.subject	atrial myocardial contractility	ru_RU
dc.title	Pacemaker currents are involved in the regulation of 3-weekold rat's atrial myocardial contractility	ru_RU
dc.type	Articles in international journals and collections	ru_RU