KFU. Card publication. Rat cardiomyocytes electrical activity during α2-adrenoreceptors stimulation after If currents blockade

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FEDERAL UNIVERSITY

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RAT CARDIOMYOCYTES ELECTRICAL ACTIVITY DURING α2-ADRENORECEPTORS STIMULATION AFTER IF CURRENTS BLOCKADE

Form of presentation

Articles in international journals and collections

Year of publication

2023

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Authors, employees of KFU

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Kupcova Anna Mikhaylovna, author

Faskhutdinov Lenar Ilsurovich, author

Authors, postgraduates KFU

Vakhitov Linar Ildarovich, postgraduate kfu

Bibliographic description in the original language

Kuptsova A.M. Rat cardiomyocytes electrical activity during α2-adrenoreceptors stimulation after If currents blockade /A.M. Kuptsova, L.I. Faskhutdinov, L.I Vakhitov, N.I. Ziyatdinova, T.L. Zefirov // Biophysical Reviews. - 2023. - Vol. 15. - p. 1468-1469.

Annotation

Biophysical Reviews

Keywords

α2-adrenoreceptors, If currents, rat heart

The name of the journal

Biophysical Reviews

URL

https://link.springer.com/article/10.1007/s12551-023-01150-w

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=290489&p_lang=2

Resource files

File name	Size (MB)	Format
F_Kupcova_biophysics_2023_44_45.pdf	0,37	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Kupcova Anna Mikhaylovna	ru_RU
dc.contributor.author	Faskhutdinov Lenar Ilsurovich	ru_RU
dc.contributor.author	Vakhitov Linar Ildarovich	ru_RU
dc.date.accessioned	2023-01-01T00:00:00Z	ru_RU
dc.date.available	2023-01-01T00:00:00Z	ru_RU
dc.date.issued	2023	ru_RU
dc.identifier.citation	Kuptsova A.M. Rat cardiomyocytes electrical activity during α2-adrenoreceptors stimulation after If currents blockade /A.M. Kuptsova, L.I. Faskhutdinov, L.I Vakhitov, N.I. Ziyatdinova, T.L. Zefirov // Biophysical Reviews. - 2023. - Vol. 15. - p. 1468-1469.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=290489&p_lang=2	ru_RU
dc.description.abstract	Biophysical Reviews	ru_RU
dc.description.abstract	The α2-adrenoreceptors (α2-AR) in mammalian heart perform the functions of regulatory efects modulation. Activation of α2-AR inhib its the synthesis of cyclic adenosine monophosphate (cAMP) by ade nylate cyclase. If currents of the myocardium cells are modulated by the level of cAMP, sympathetic and parasympathetic departments of the autonomic nervous system. Modulation of the If currents activity via cAMP is essential in the increase or decrease of heart rate by the departments of the autonomic nervous system. It has been shown that activation of adrenergic receptors activates If and thereby increases the chronotropic function of the heart through β-adrenoreceptor dependent increase in the level of cAMP. Since HCN channels and α2-AR are pre sent in cardiomyocytes, it is possible that If currents are an efector of adrenergic regulation of the heart through this type of receptor as well. The aim of this study is to investigate the efect of α2-adrenoreceptor stimulation after If preliminary blockade on the electrical activity of rat cardiomyocytes.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	α2-adrenoreceptors	ru_RU
dc.subject	If currents	ru_RU
dc.subject	rat heart	ru_RU
dc.title	Rat cardiomyocytes electrical activity during α2-adrenoreceptors stimulation after If currents blockade	ru_RU
dc.type	Articles in international journals and collections	ru_RU