| Form of presentation | Articles in international journals and collections |
| Year of publication | 2023 |
| Язык | русский |
|
Zefirov Timur Lvovich, author
Ziyatdinova Nafisa Ilgizovna, author
Krylova Alevtina Vasilevna, author
|
|
Zefirov Andrey Lvovich, author
|
|
Leonova Alina Maratovna, postgraduate kfu
|
| Bibliographic description in the original language |
Galieva A.M. Electrical activity of rat working myocardiocytes during alpha2-adrenoreceptor stimulation / A.M. Galieva, Zefrov A.L., Ziyatdinova N.I., Krylova A.V., Zefirov T.L. // Biophysical Reviews. - 2023. - Vol. 15. - p. 1502 |
| Annotation |
It is known that isolated rat myocardium contains beta1-adrenoreceptors, beta2-adrenoreceptors, beta3-adrenoreceptors, beta4-adrenoreceptors, as well as alpha1-adrenoreceptors and alpha2-adrenoreceptors.
Research indicate that α2-AR isoforms (α2А-, α2B- and α2C) are expressed in cardiac myocytes with the potential to safeguard cardiac muscle under adrenergic surge by governing intracellular Ca2+
handling and contractility. By adjusting the balance between protein kinase and phosphatase activities, sarcolemmal α2-ARs are capable of counterbalancing signaling cascades that provoke hypertrophic cardiac remodeling under chronic activation of adrenergic and angiotensinergic
signaling. In this regard, the reprograming gene or cell based therapies aimed at cardiac specifc restoration or enhancement of α2-AR signaling may represent future therapeutic directions for prevention or treatment of heart failure. |
| Keywords |
working myocardiocytes, alpha2-adrenoreceptor |
| The name of the journal |
Biophysical Reviews
|
| URL |
https://link.springer.com/article/10.1007/s12551-023-01150-w |
| Please use this ID to quote from or refer to the card |
https://repository.kpfu.ru/eng/?p_id=290512&p_lang=2 |
| Resource files | |
|
|
Full metadata record  |
| Field DC |
Value |
Language |
| dc.contributor.author |
Zefirov Timur Lvovich |
ru_RU |
| dc.contributor.author |
Ziyatdinova Nafisa Ilgizovna |
ru_RU |
| dc.contributor.author |
Krylova Alevtina Vasilevna |
ru_RU |
| dc.contributor.author |
Zefirov Andrey Lvovich |
ru_RU |
| dc.contributor.author |
Leonova Alina Maratovna |
ru_RU |
| dc.date.accessioned |
2023-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2023-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2023 |
ru_RU |
| dc.identifier.citation |
Galieva A.M. Electrical activity of rat working myocardiocytes during alpha2-adrenoreceptor stimulation / A.M. Galieva, Zefrov A.L., Ziyatdinova N.I., Krylova A.V., Zefirov T.L. // Biophysical Reviews. - 2023. - Vol. 15. - p. 1502 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/eng/?p_id=290512&p_lang=2 |
ru_RU |
| dc.description.abstract |
Biophysical Reviews |
ru_RU |
| dc.description.abstract |
It is known that isolated rat myocardium contains beta1-adrenoreceptors, beta2-adrenoreceptors, beta3-adrenoreceptors, beta4-adrenoreceptors, as well as alpha1-adrenoreceptors and alpha2-adrenoreceptors.
Research indicate that α2-AR isoforms (α2А-, α2B- and α2C) are expressed in cardiac myocytes with the potential to safeguard cardiac muscle under adrenergic surge by governing intracellular Ca2+
handling and contractility. By adjusting the balance between protein kinase and phosphatase activities, sarcolemmal α2-ARs are capable of counterbalancing signaling cascades that provoke hypertrophic cardiac remodeling under chronic activation of adrenergic and angiotensinergic
signaling. In this regard, the reprograming gene or cell based therapies aimed at cardiac specifc restoration or enhancement of α2-AR signaling may represent future therapeutic directions for prevention or treatment of heart failure. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
working myocardiocytes |
ru_RU |
| dc.subject |
alpha2-adrenoreceptor |
ru_RU |
| dc.title |
Electrical activity of rat working myocardiocytes during alpha2-adrenoreceptor stimulation |
ru_RU |
| dc.type |
Articles in international journals and collections |
ru_RU |
|
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