KFU. Card publication. Participation of alpha2-adrenoreceptors in the regulation of bioelectrical parameters of newborn rat atrial cardiomyocytes

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PARTICIPATION OF ALPHA2-ADRENORECEPTORS IN THE REGULATION OF BIOELECTRICAL PARAMETERS OF NEWBORN RAT ATRIAL CARDIOMYOCYTES

Form of presentation

Articles in Russian journals and collections

Year of publication

2023

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Authors, employees of KFU

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Iskakov Nikita Georgievich, author

Other authors

Zefirov Andrey Lvovich, author

Authors, postgraduates KFU

Leonova Alina Maratovna, postgraduate kfu

Bibliographic description in the original language

Galieva A.M. Participation of alpha2-adrenoreceptors in the regulation of bioelectrical parameters of newborn rat atrial cardiomyocytes /A.M. Galieva, N.I. Ziyatdinova, A.L. Zefrov ,N.G. Iskakov, T.L. Zefrov // Biophysical Reviews. - 2023. - Vol. 15. - p. 1515-1516.

Annotation

Adrenergic receptors, also called adrenoceptors, are proteins composed of 400 to 600 aminoacids, with seven membrane-spanning domains, and belong to the superfamily of G protein-coupled receptors (GPCR). They are membrane receptors that activate G proteins following the binding of a ligand, thus causing a change in the cell membrane permeability to one or more ions and/or activating an enzyme attached to the receptor. Gs and Gi proteins activate and inhibit the enzyme adenylylcyclase respectively, while Gq proteins activate phospholipase C. According to a number of authors, in rat ventricular and guinea pig and human atrial myocardium, activation of alpha2-adrenoreceptors leads to Gi-protein activation, which decreases adenylate cyclase activity, cAMP level, and thus protein kinase A activity, which eventually blocks norepinephrine exocytosis. Furthermore, it is not excluded that the Gq protein-protein kinase C pathway is also involved in this process. it is believed that alpha2-adrenoceptor subtypes (a-, c-, and c-) are associated with Gi protein, i.e., they implement a single signaling system.

Keywords

alpha2-adrenoreceptors, bioelectrical parameters, newborn rat, atrial cardiomyocytes

The name of the journal

Biophysical Reviews

URL

https://link.springer.com/article/10.1007/s12551-023-01150-w

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=290515&p_lang=2

Resource files

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Galieva_A._biophysics_2023_91_92.pdf	0,37	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Iskakov Nikita Georgievich	ru_RU
dc.contributor.author	Zefirov Andrey Lvovich	ru_RU
dc.contributor.author	Leonova Alina Maratovna	ru_RU
dc.date.accessioned	2023-01-01T00:00:00Z	ru_RU
dc.date.available	2023-01-01T00:00:00Z	ru_RU
dc.date.issued	2023	ru_RU
dc.identifier.citation	Galieva A.M. Participation of alpha2-adrenoreceptors in the regulation of bioelectrical parameters of newborn rat atrial cardiomyocytes /A.M. Galieva, N.I. Ziyatdinova, A.L. Zefrov ,N.G. Iskakov, T.L. Zefrov // Biophysical Reviews. - 2023. - Vol. 15. - p. 1515-1516.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=290515&p_lang=2	ru_RU
dc.description.abstract	Biophysical Reviews	ru_RU
dc.description.abstract	Adrenergic receptors, also called adrenoceptors, are proteins composed of 400 to 600 aminoacids, with seven membrane-spanning domains, and belong to the superfamily of G protein-coupled receptors (GPCR). They are membrane receptors that activate G proteins following the binding of a ligand, thus causing a change in the cell membrane permeability to one or more ions and/or activating an enzyme attached to the receptor. Gs and Gi proteins activate and inhibit the enzyme adenylylcyclase respectively, while Gq proteins activate phospholipase C. According to a number of authors, in rat ventricular and guinea pig and human atrial myocardium, activation of alpha2-adrenoreceptors leads to Gi-protein activation, which decreases adenylate cyclase activity, cAMP level, and thus protein kinase A activity, which eventually blocks norepinephrine exocytosis. Furthermore, it is not excluded that the Gq protein-protein kinase C pathway is also involved in this process. it is believed that alpha2-adrenoceptor subtypes (a-, c-, and c-) are associated with Gi protein, i.e., they implement a single signaling system.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	alpha2-adrenoreceptors	ru_RU
dc.subject	bioelectrical parameters	ru_RU
dc.subject	newborn rat	ru_RU
dc.subject	atrial cardiomyocytes	ru_RU
dc.title	Participation of alpha2-adrenoreceptors in the regulation of bioelectrical parameters of newborn rat atrial cardiomyocytes	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU