KFU. Card publication. Peculiarities of AP repolarization in cardiomyocytes of three-week-old rats during application of clonidine hydrochloride

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PECULIARITIES OF AP REPOLARIZATION IN CARDIOMYOCYTES OF THREE-WEEK-OLD RATS DURING APPLICATION OF CLONIDINE HYDROCHLORIDE

Form of presentation

Articles in international journals and collections

Year of publication

2023

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Authors, employees of KFU

Biktemirova Raisa Gabdullovna, author

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Authors, postgraduates KFU

Leonova Alina Maratovna, postgraduate kfu

Shakirov Ranis Rishatovich, postgraduate kfu

Bibliographic description in the original language

Galieva A.M. Peculiarities of AP repolarization in cardiomyocytes of three-week-old rats during application of clonidine hydrochloride / A.M. Galieva , N.I. Ziyatdinova ,R.R. Shakirov , R.G. Biktemirova,T.L. Zefrov //

Annotation

Activation of the sympathetic nervous system is responsible for the body's “fght or fight” reaction. The physiological responses to the activation of the sympathetic nervous system and adrenal medulla are mediated through the action of the endogenous catecholamines norepinephrine (or noradrenaline) and epinephrine (or adrenaline) on adrenergic receptors. Adrenergic receptors belong to the superfamily of G protein-coupled receptors (GPCR). Adrenoceptors are divided into alpha1, alpha2, beta1, beta2 and beta3 receptors. α2 receptors are coupled to inhibitory Gi proteins, that inactivate adenylyl cyclase, decreasing cyclic adenosine monophosphate (AMP) production. In addition to the endogenous ligands epinephrine and norepinephrine, they may be activated by several agonist drugs, including clonidine, brimonidine, and moxonidine.

Keywords

cardiomyocytes, three-week-old rats, clonidine hydrochloride

The name of the journal

Biophysical Reviews

URL

https://link.springer.com/article/10.1007/s12551-023-01150-w

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=290517&p_lang=2

Resource files

File name	Size (MB)	Format
Galieva_A._biophysics_2023_92_93.pdf	0,37	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Biktemirova Raisa Gabdullovna	ru_RU
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Leonova Alina Maratovna	ru_RU
dc.contributor.author	Shakirov Ranis Rishatovich	ru_RU
dc.date.accessioned	2023-01-01T00:00:00Z	ru_RU
dc.date.available	2023-01-01T00:00:00Z	ru_RU
dc.date.issued	2023	ru_RU
dc.identifier.citation	Galieva A.M. Peculiarities of AP repolarization in cardiomyocytes of three-week-old rats during application of clonidine hydrochloride / A.M. Galieva , N.I. Ziyatdinova ,R.R. Shakirov , R.G. Biktemirova,T.L. Zefrov //	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=290517&p_lang=2	ru_RU
dc.description.abstract	Biophysical Reviews	ru_RU
dc.description.abstract	Activation of the sympathetic nervous system is responsible for the body's “fght or fight” reaction. The physiological responses to the activation of the sympathetic nervous system and adrenal medulla are mediated through the action of the endogenous catecholamines norepinephrine (or noradrenaline) and epinephrine (or adrenaline) on adrenergic receptors. Adrenergic receptors belong to the superfamily of G protein-coupled receptors (GPCR). Adrenoceptors are divided into alpha1, alpha2, beta1, beta2 and beta3 receptors. α2 receptors are coupled to inhibitory Gi proteins, that inactivate adenylyl cyclase, decreasing cyclic adenosine monophosphate (AMP) production. In addition to the endogenous ligands epinephrine and norepinephrine, they may be activated by several agonist drugs, including clonidine, brimonidine, and moxonidine.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	cardiomyocytes	ru_RU
dc.subject	three-week-old rats	ru_RU
dc.subject	clonidine hydrochloride	ru_RU
dc.title	Peculiarities of AP repolarization in cardiomyocytes of three-week-old rats during application of clonidine hydrochloride	ru_RU
dc.type	Articles in international journals and collections	ru_RU