KFU. Card publication. Evaluation of the effectiveness and safety of photodynamic therapy in the treatment of precancerous diseases of the cervix (neoplasia) associated with the human papillomavirus: A systematic review

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EVALUATION OF THE EFFECTIVENESS AND SAFETY OF PHOTODYNAMIC THERAPY IN THE TREATMENT OF PRECANCEROUS DISEASES OF THE CERVIX (NEOPLASIA) ASSOCIATED WITH THE HUMAN PAPILLOMAVIRUS: A SYSTEMATIC REVIEW

Form of presentation

Articles in international journals and collections

Year of publication

2024

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Authors, employees of KFU

Zinchenko Sergey Viktorovich, author

Bibliographic description in the original language

Shanazarov, N. Evaluation of the effec-tiveness and safety of pho-todynamic therapy in the treatment of precancerous diseases of the cervix (neo-plasia) associated with the/ N. Shanazarov, G. Bariyeva, A.Avdeev,R.Albayevm, S.Kisikova, S. Zinchenko, I.Galiev/Photodiagnosis and Photodynamic Therapy. - 2024. - Vol.45, Is.. - Art. �103925.

Annotation

This study provides an overview of the effectiveness and safety of PDT for the treatment of HPV-associated precancerous cervical conditions and contains recent findings from relevant research studies. A comprehensive literature search of MEDLINE/PubMed, Cochrane Central Library, and Google Scholar was conducted, including analytic epidemiological studies, and 11 papers were included. The narrative synthesis approach was used to summarize the results of the included studies. Studies were critically appraised using The Joanna Briggs Institute (JBI) tool for assessing the risk of bias. The results of the study demonstrate that CRR for HPV remission ranges from 66.7 % to 92.73 %, whereas for CIN1 it fluctuates from 57.1 % to 83.3 %. The frequency of recurrence of the disease ranged from 3.3 % to 8.9 % during the follow-up period of up to 2 years. Adverse events were observed in 8 (66 %) studies and the most common were cervical stenosis, abdominal pain, vaginal pain, and focal edema. Five types of topical and intravenous applications along with lasers of various wavelengths and intensities were mostly used. However, all studies demonstrated relatively similar results. According to the results, PDT has demonstrated favorable outcomes, but no impressive effect on the treatment of CIN. It should be emphasized, that the effectiveness of PDT for the treatment of HPV-associated CIN may vary depending on some variables, including the kind of PDT agent used, the dosage, duration and frequency of PDT administration, the severity and location of the lesions, and the host immunological response.

Keywords

Cervical intraepithelial neoplasia Oncology Human papillomavirus Photodynamic therapy Effectiveness

The name of the journal

Photodiagnosis and Photodynamic Therapy

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85180800095&doi=10.1016%2fj.pdpdt.2023.103925&partnerID=40&md5=093ef48bcf5fe00f62d3537c8d0cc94f

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=295111&p_lang=2

Resource files

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Photodiagnosis_and_Photodynamic_Therapy.pdf	0,71	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zinchenko Sergey Viktorovich	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Shanazarov, N. Evaluation of the effec-tiveness and safety of pho-todynamic therapy in the treatment of precancerous diseases of the cervix (neo-plasia) associated with the/ N. Shanazarov, G. Bariyeva, A.Avdeev,R.Albayevm, S.Kisikova, S. Zinchenko, I.Galiev/Photodiagnosis and Photodynamic Therapy. - 2024. - Vol.45, Is.. - Art. �103925.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=295111&p_lang=2	ru_RU
dc.description.abstract	Photodiagnosis and Photodynamic Therapy	ru_RU
dc.description.abstract	This study provides an overview of the effectiveness and safety of PDT for the treatment of HPV-associated precancerous cervical conditions and contains recent findings from relevant research studies. A comprehensive literature search of MEDLINE/PubMed, Cochrane Central Library, and Google Scholar was conducted, including analytic epidemiological studies, and 11 papers were included. The narrative synthesis approach was used to summarize the results of the included studies. Studies were critically appraised using The Joanna Briggs Institute (JBI) tool for assessing the risk of bias. The results of the study demonstrate that CRR for HPV remission ranges from 66.7 % to 92.73 %, whereas for CIN1 it fluctuates from 57.1 % to 83.3 %. The frequency of recurrence of the disease ranged from 3.3 % to 8.9 % during the follow-up period of up to 2 years. Adverse events were observed in 8 (66 %) studies and the most common were cervical stenosis, abdominal pain, vaginal pain, and focal edema. Five types of topical and intravenous applications along with lasers of various wavelengths and intensities were mostly used. However, all studies demonstrated relatively similar results. According to the results, PDT has demonstrated favorable outcomes, but no impressive effect on the treatment of CIN. It should be emphasized, that the effectiveness of PDT for the treatment of HPV-associated CIN may vary depending on some variables, including the kind of PDT agent used, the dosage, duration and frequency of PDT administration, the severity and location of the lesions, and the host immunological response.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Evaluation of the effectiveness and safety of photodynamic therapy in the treatment of precancerous diseases of the cervix (neoplasia) associated with the human papillomavirus: A systematic review	ru_RU
dc.type	Articles in international journals and collections	ru_RU