KFU. Card publication. Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer?s Disease Drug Determination

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FEDERAL UNIVERSITY

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ELECTROCHEMICAL ACETYLCHOLINESTERASE SENSORS FOR ANTI-ALZHEIMER?S DISEASE DRUG DETERMINATION

Form of presentation

Articles in international journals and collections

Year of publication

2024

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Authors, employees of KFU

Evtyugin Gennadiy Arturovich, author

Ivanov Aleksey Nikolaevich, author

Bibliographic description in the original language

Ivanov A, Shamagsumova R, Larina M, Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer?s Disease Drug Determination//Biosensors. - 2024. - Vol.14, Is.2. - Art. �93.

Annotation

Neurodegenerative diseases and Alzheimer's disease (AD), as one of the most common causes of dementia, result in progressive losses of cholinergic neurons and a reduction in the presynaptic markers of the cholinergic system. These consequences can be compensated by the inhibition of acetylcholinesterase (AChE) followed by a decrease in the rate of acetylcholine hydrolysis. For this reason, anticholinesterase drugs with reversible inhibition effects are applied for the administration of neurodegenerative diseases. Their overdosage, variation in efficiency and recommendation of an individual daily dose require simple and reliable measurement devices capable of the assessment of the drug concentration in biological fluids and medications. In this review, the performance of electrochemical biosensors utilizing immobilized cholinesterases is considered to show their advantages and drawbacks in the determination of anticholinesterase drugs. In addition, common drugs applied in treating neurodegenerative diseases are briefly characterized. The immobilization of enzymes, nature of the signal recorded and its dependence on the transducer modification are considered and the analytical characteristics of appropriate biosensors are summarized for donepezil, huperzine A, rivastigmine, eserine and galantamine as common anti-dementia drugs. Finally, the prospects for the application of AChE-based biosensors in clinical practice are discussed.

Keywords

acetylcholinesteras, drug determination, electrochemical biosensor, reversible inhibition

The name of the journal

Biosensors

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185714550&doi=10.3390%2fbios14020093&partnerID=40&md5=e24d10c6dcc2a81ac9c68b42b7bcd41b

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=297436&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Evtyugin Gennadiy Arturovich	ru_RU
dc.contributor.author	Ivanov Aleksey Nikolaevich	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Ivanov A, Shamagsumova R, Larina M, Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer?s Disease Drug Determination//Biosensors. - 2024. - Vol.14, Is.2. - Art. �93.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=297436&p_lang=2	ru_RU
dc.description.abstract	Biosensors	ru_RU
dc.description.abstract	Neurodegenerative diseases and Alzheimer's disease (AD), as one of the most common causes of dementia, result in progressive losses of cholinergic neurons and a reduction in the presynaptic markers of the cholinergic system. These consequences can be compensated by the inhibition of acetylcholinesterase (AChE) followed by a decrease in the rate of acetylcholine hydrolysis. For this reason, anticholinesterase drugs with reversible inhibition effects are applied for the administration of neurodegenerative diseases. Their overdosage, variation in efficiency and recommendation of an individual daily dose require simple and reliable measurement devices capable of the assessment of the drug concentration in biological fluids and medications. In this review, the performance of electrochemical biosensors utilizing immobilized cholinesterases is considered to show their advantages and drawbacks in the determination of anticholinesterase drugs. In addition, common drugs applied in treating neurodegenerative diseases are briefly characterized. The immobilization of enzymes, nature of the signal recorded and its dependence on the transducer modification are considered and the analytical characteristics of appropriate biosensors are summarized for donepezil, huperzine A, rivastigmine, eserine and galantamine as common anti-dementia drugs. Finally, the prospects for the application of AChE-based biosensors in clinical practice are discussed.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	acetylcholinesteras	ru_RU
dc.subject	drug determination	ru_RU
dc.subject	electrochemical biosensor	ru_RU
dc.subject	reversible inhibition	ru_RU
dc.title	Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer?s Disease Drug Determination	ru_RU
dc.type	Articles in international journals and collections	ru_RU