KFU. Card publication. Solid-State Preparation of Inclusion Compounds of Native Cyclodextrins with Diclofenac Sodium

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FEDERAL UNIVERSITY

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SOLID-STATE PREPARATION OF INCLUSION COMPOUNDS OF NATIVE CYCLODEXTRINS WITH DICLOFENAC SODIUM

Form of presentation

Articles in Russian journals and collections

Year of publication

2024

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Authors, employees of KFU

Gatiatulin Askar Kamilevich, author

Gorbachuk Valeriy Vilenovich, author

Ziganshin Marat Akhmedovich, author

Klimovickiy Aleksandr Evgenevich, author

Bibliographic description in the original language

Gatiatulin, A.K., Klimovitskii, A.E., Ziganshin, M.A. and Gorbatchuk, V.V. Solid-State Preparation of Inclusion Compounds of Native Cyclodextrins with Diclofenac Sodium. Russ J Gen Chem 94, 1967–1971 (2024). https://doi.org/10.1134/S1070363224080097

Annotation

Inclusion compounds of diclofenac sodium, a non-steroidal anti-inflammatory drug, with native α-, β- and γ-cyclodextrins at varying levels of hydration were prepared by co-grinding in a ball mill. Using TG/DSC analysis, powder X-ray diffraction and solid-state IR spectroscopy, it was shown that when equimolar mixtures of native cyclodextrin and diclofenac are milled, complete inclusion of this pharmaceutical ingredient occurs, regardless of cyclodextrin hydration. The absence of water-guest competition in the solid-state inclusion process is explained by high affinity of diclofenac sodium to cyclodextrins. The prepared complexes have a significantly lower thermal stability than the separate native cyclodextrins and diclofenac sodium.

Keywords

cyclodextrin, diclofenac, inclusion compound, encapsulation

The name of the journal

Russian Journal of General Chemistry

URL

https://link.springer.com/article/10.1134/S1070363224080097

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=304984&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gatiatulin Askar Kamilevich	ru_RU
dc.contributor.author	Gorbachuk Valeriy Vilenovich	ru_RU
dc.contributor.author	Ziganshin Marat Akhmedovich	ru_RU
dc.contributor.author	Klimovickiy Aleksandr Evgenevich	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Gatiatulin, A.K., Klimovitskii, A.E., Ziganshin, M.A. and Gorbatchuk, V.V. Solid-State Preparation of Inclusion Compounds of Native Cyclodextrins with Diclofenac Sodium. Russ J Gen Chem 94, 1967–1971 (2024). https://doi.org/10.1134/S1070363224080097	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=304984&p_lang=2	ru_RU
dc.description.abstract	Russian Journal of General Chemistry	ru_RU
dc.description.abstract	Inclusion compounds of diclofenac sodium, a non-steroidal anti-inflammatory drug, with native α-, β- and γ-cyclodextrins at varying levels of hydration were prepared by co-grinding in a ball mill. Using TG/DSC analysis, powder X-ray diffraction and solid-state IR spectroscopy, it was shown that when equimolar mixtures of native cyclodextrin and diclofenac are milled, complete inclusion of this pharmaceutical ingredient occurs, regardless of cyclodextrin hydration. The absence of water-guest competition in the solid-state inclusion process is explained by high affinity of diclofenac sodium to cyclodextrins. The prepared complexes have a significantly lower thermal stability than the separate native cyclodextrins and diclofenac sodium.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	cyclodextrin	ru_RU
dc.subject	diclofenac	ru_RU
dc.subject	inclusion compound	ru_RU
dc.subject	encapsulation	ru_RU
dc.title	Solid-State Preparation of Inclusion Compounds of Native Cyclodextrins with Diclofenac Sodium	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU