KFU. Card publication. Predictive biomarkers for the diagnosis of different clinical forms of cardiovascular disease

KAZAN
FEDERAL UNIVERSITY

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PREDICTIVE BIOMARKERS FOR THE DIAGNOSIS OF DIFFERENT CLINICAL FORMS OF CARDIOVASCULAR DISEASE

Form of presentation

Articles in international journals and collections

Year of publication

2024

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Authors, employees of KFU

Abramov Sergey Nikolaevich, author

Abramova Zinaida Ivanovna, author

Ganeeva Liliya Akhatovna, author

Skibo Yuliya Valerevna, author

Other authors

LEGBA BORIS B. , author

VODOUNON CYRILLE A. , author

Bibliographic description in the original language

Vodounon Cyrille A. Predictive biomarkers for the diagnosis of different clinical forms of cardiovascular disease/ Cyrille A. Vodounon, Lilya A. Ganeeva, Sergey N. Abramov, Boris B. Legba, Yulia V. Skibo, Zinaida I. Abramova //JCDR. - 2024.- V. 15, Is 10. - P.1672-1689

Annotation

Journal of Cardiovascular Disease Research

Keywords

predictive biomarkers, diagnosis, cardiovascular disease

The name of the journal

Journal of Cardiovascular Disease Research

URL

https://www.jcdronline.org/paper.php?slug=predictive-biomarkers-for-the-diagnosis-of-different-clinical-forms-of-cardiovascular-disease

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=308832&p_lang=2

Resource files

File name	Size (MB)	Format
PREDICTIVE_BIOMARKERS_FOR_T_E_DIAGNOSIS_statya_2024.pdf	0,70	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abramov Sergey Nikolaevich	ru_RU
dc.contributor.author	Abramova Zinaida Ivanovna	ru_RU
dc.contributor.author	Ganeeva Liliya Akhatovna	ru_RU
dc.contributor.author	Skibo Yuliya Valerevna	ru_RU
dc.contributor.author	LEGBA BORIS B.	ru_RU
dc.contributor.author	VODOUNON CYRILLE A.	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Vodounon Cyrille A. Predictive biomarkers for the diagnosis of different clinical forms of cardiovascular disease/ Cyrille A. Vodounon, Lilya A. Ganeeva, Sergey N. Abramov, Boris B. Legba, Yulia V. Skibo, Zinaida I. Abramova //JCDR. - 2024.- V. 15, Is 10. - P.1672-1689	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=308832&p_lang=2	ru_RU
dc.description.abstract	Journal of Cardiovascular Disease Research	ru_RU
dc.description.abstract	Cardiovascular disease is a major health problem worldwide. One of the current challenges related to its prevention is that of early diagnosis and prognosis. This study focuses on the role of anti-DNA antibody in the diagnosis of different clinical forms of cardiovascular diseases. Anti-DNA antibodies were searched in the blood serum of 57 patients with cardiovascular disease of various forms and 27 relatively healthy donors. The determination of the level of anti-DNA antibodies was conducted by enzyme immunoassay. The catalytic activity of the antibodies was studied and the product was estimated by the agarose gel electrophoresis method. The results showed that the level of anti-DNA antibodies in patients with cardiovascular disease is significantly high compared to the level of the anti-DNA antibodies of found in DRS serum. A high level of antibody to double stranded DNA was observed in 70.70% of patients with cardiovascular diseases. The results of correlational analysis showed a direct feature dependency relationship between the antibody to double stranded DNA level and the antibody to single stranded DNA level with a correlation coefficient Rs=0.65 reaching a significant level, as the test value of the statistics (6.5) exceeded its tabular value (2.0). The anti-DNA antibodies found in the serum of the different groups of patients of cardiovascular diseases exhibit catalytic activities and are able to transform the super-coiled DNA of plasmids into linear and circular DNA. There is an inverse dependence relationship between the level of antibody and the catalytic activity rate. The results obtained lead us to suggest that the antiDNA antibodies play a significant role in the etiology of different form of cardiovascular disease and could be used as a biomarker in the diagnosis and the prognosis of the different form of this disease	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	predictive biomarkers	ru_RU
dc.subject	diagnosis	ru_RU
dc.subject	cardiovascular disease	ru_RU
dc.title	Predictive biomarkers for the diagnosis of different clinical forms of cardiovascular disease	ru_RU
dc.type	Articles in international journals and collections	ru_RU