KFU. Card publication. RIGHT ATRIAL CARDIOMYOCYTES ACTION POTENTIAL AMPLITUDE-TIME CHARACTERISTICS UNDER LEFT VENTRICLE EXPERIMENTAL MYOCARDIAL INFARCTION

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RIGHT ATRIAL CARDIOMYOCYTES ACTION POTENTIAL AMPLITUDE-TIME CHARACTERISTICS UNDER LEFT VENTRICLE EXPERIMENTAL MYOCARDIAL INFARCTION

Form of presentation

Articles in Russian journals and collections

Year of publication

2025

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Authors, employees of KFU

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Iskakov Nikita Georgievich, author

Kupcova Anna Mikhaylovna, author

Mansur Nur , author

Other authors

Zverev Aleksey Anatolevich, author

Bibliographic description in the original language

Kuptsova A.M. RIGHT ATRIAL CARDIOMYOCYTES ACTION POTENTIAL AMPLITUDE-TIME CHARACTERISTICS UNDER LEFT VENTRICLE EXPERIMENTAL MYOCARDIAL INFARCTION / A.M.Kuptsova, N. Mansour, A.A. Zverev, N.G. Iskakov, N.I. Ziyatdinova, T.L. Zefirov // Opera Med Physiol. 2025. - Vol. 12 (2). - r. 68-73.

Annotation

Cardiovascular diseases are among the most prevalent pathologies worldwide, and myocardial infarction (MI) is a common cause of ventricular arrhythmias and sudden cardiac death. The development of MI is accompanied by profound alterations in the electrophysiological properties of cardiomyocytes, including a decrease in the amplitude and propagation velocity of the action potential. These changes lead to disturbances in excitability and impulse conduction not only in the affected region but also throughout the entire heart. Understanding the mechanisms underlying these alterations is crucial for developing novel approaches to the prevention and treatment of cardiovascular complications. The study aimed to investigate the dynamics of electrical activity changes in the right atrial myocardium at different stages of left ventricular myocardial infarction (MI) development in rats. Experimental MI was induced by ligation of the left coronary artery. We evaluated the effects of acute, subacute, and long-term consequences MI phases on the amplitude-time characteristics of action potentials in working right atrial cardiomyocytes.

Keywords

myocardial infarction, action potential duration, heart, rat.

The name of the journal

Opera Medica et Physiologica

URL

https://operamedphys.org/content/right-atrial-cardiomyocytes-action-potential-amplitude-time-characteristics-under-left-0

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=314837&p_lang=2

Resource files

File name	Size (MB)	Format
OPERA_2025.pdf	0,35	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Iskakov Nikita Georgievich	ru_RU
dc.contributor.author	Kupcova Anna Mikhaylovna	ru_RU
dc.contributor.author	Mansur Nur	ru_RU
dc.contributor.author	Zverev Aleksey Anatolevich	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Kuptsova A.M. RIGHT ATRIAL CARDIOMYOCYTES ACTION POTENTIAL AMPLITUDE-TIME CHARACTERISTICS UNDER LEFT VENTRICLE EXPERIMENTAL MYOCARDIAL INFARCTION / A.M.Kuptsova, N. Mansour, A.A. Zverev, N.G. Iskakov, N.I. Ziyatdinova, T.L. Zefirov // Opera Med Physiol. 2025. - Vol. 12 (2). - �. 68-73.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=314837&p_lang=2	ru_RU
dc.description.abstract	Opera Medica et Physiologica	ru_RU
dc.description.abstract	Cardiovascular diseases are among the most prevalent pathologies worldwide, and myocardial infarction (MI) is a common cause of ventricular arrhythmias and sudden cardiac death. The development of MI is accompanied by profound alterations in the electrophysiological properties of cardiomyocytes, including a decrease in the amplitude and propagation velocity of the action potential. These changes lead to disturbances in excitability and impulse conduction not only in the affected region but also throughout the entire heart. Understanding the mechanisms underlying these alterations is crucial for developing novel approaches to the prevention and treatment of cardiovascular complications. The study aimed to investigate the dynamics of electrical activity changes in the right atrial myocardium at different stages of left ventricular myocardial infarction (MI) development in rats. Experimental MI was induced by ligation of the left coronary artery. We evaluated the effects of acute, subacute, and long-term consequences MI phases on the amplitude-time characteristics of action potentials in working right atrial cardiomyocytes.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	myocardial infarction	ru_RU
dc.subject	action potential duration	ru_RU
dc.subject	heart	ru_RU
dc.subject	rat.	ru_RU
dc.title	RIGHT ATRIAL CARDIOMYOCYTES ACTION POTENTIAL AMPLITUDE-TIME CHARACTERISTICS UNDER LEFT VENTRICLE EXPERIMENTAL MYOCARDIAL INFARCTION	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU