KFU. Card publication. The Combined Delivery of the Vegf, Ang, and Gdnf Genes Stimulates Angiogenesis and Improves Post-Ischemic Innervation and Regeneration in Skeletal Muscle

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THE COMBINED DELIVERY OF THE VEGF, ANG, AND GDNF GENES STIMULATES ANGIOGENESIS AND IMPROVES POST-ISCHEMIC INNERVATION AND REGENERATION IN SKELETAL MUSCLE

Form of presentation

Articles in Russian journals and collections

Year of publication

2024

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Authors, employees of KFU

Zakirova Elena Yurevna, author

Bibliographic description in the original language

Samatoshenkov I. V. The Combined Delivery of the Vegf, Ang, and Gdnf Genes Stimulates Angiogenesis and Improves Post-Ischemic Innervation and Regeneration in Skeletal Muscle / I. V. Samatoshenkov, A. M. Aimaletdinov, E. Yu. Zakirova [et al.] // Current Issues in Molecular Biology. - 2024. – Vol. 46, No. 8. – P. 8611-8626.h; DOI 10.3390/cimb46080507

Annotation

Current Issues in Molecular Biology

Keywords

Vegf, Ang, and Gdnf Genes

The name of the journal

Current Issues in Molecular Biology

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https://repository.kpfu.ru/eng/?p_id=315897&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zakirova Elena Yurevna	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Samatoshenkov I. V. The Combined Delivery of the Vegf, Ang, and Gdnf Genes Stimulates Angiogenesis and Improves Post-Ischemic Innervation and Regeneration in Skeletal Muscle / I. V. Samatoshenkov, A. M. Aimaletdinov, E. Yu. Zakirova [et al.] // Current Issues in Molecular Biology. - 2024. – Vol. 46, No. 8. – P. 8611-8626.h; DOI 10.3390/cimb46080507	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=315897&p_lang=2	ru_RU
dc.description.abstract	Current Issues in Molecular Biology	ru_RU
dc.description.abstract	In this study, the effects of different combinations of the genes Vegf, Ang, and Gdnf injected both using direct virus-mediated injection (adenovirus, Ad5) and umbilical cord blood mononuclear cells (UCBCs) on the processes of stimulation of post-ischemic innervation, angiogenesis, and regeneration in skeletal muscle were investigated in a rat hindlimb chronic ischemia model. It was shown that more pronounced stimulation of angiogenesis and restoration of post-ischemic innervation were achieved both in the early (28 days post-ischemia, dpi) and late (42 dpi) terms of the experiment in the calf muscle when UCBCs delivered the combination of Ad5-Vegf and Ad5-Ang compared to the direct injection of the same vector combination into the area of ischemia. At the same time, the inclusion of Ad5-Gdnf in the combination of Ad5-Vegf and Ad5-Ang directly injected or administered by UCBCs provided a significant increase in the number of centronuclear muscle fibers, indicating stimulation of post-ischemic reparative myogenesis. This study allowed us to determine the most effective gene combinations for angiogenesis and neurogenesis, which, in the future, may serve as the basis for the development of gene and gene cell products for the treatment of chronic lower limb ischemia.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Vegf	ru_RU
dc.subject	Ang	ru_RU
dc.subject	and Gdnf Genes	ru_RU
dc.title	The Combined Delivery of the Vegf, Ang, and Gdnf Genes Stimulates Angiogenesis and Improves Post-Ischemic Innervation and Regeneration in Skeletal Muscle	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU