KFU. Card publication. A voltammetric sensor based on tin dioxide nanoparticles for the determination of Taxifolin

KAZAN
FEDERAL UNIVERSITY

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A VOLTAMMETRIC SENSOR BASED ON TIN DIOXIDE NANOPARTICLES FOR THE DETERMINATION OF TAXIFOLIN

Form of presentation

Articles in international journals and collections

Year of publication

2025

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Authors, employees of KFU

Ziyatdinova Guzel Kamilevna, author

Authors, students KFU

Tarabukina Anna Denisovna, author

Bibliographic description in the original language

Ziyatdinova, G.K. A voltammetric sensor based on tin dioxide nanoparticles for the determination of Taxifolin / G.K. Ziyatdinova, A.D. Tarabukina // J. Anal. Chem. - 2025. - V. 80. - � 7. - P. 1264-1273.

Annotation

A voltammetric sensor for the determination of taxifolin is developed based on a glassy carbon electrode (GCE) modified with tin dioxide nanoparticles (SnO2 NPs) dispersed in N-hexadecylpyridinium bromide. The modification of the electrode surface enhances the reversibility of the electrochemical reaction and significantly increases redox currents compared to an unmodified GCE, by factors of 2.3 and 3.3 for the anodic and cathodic peaks, respectively. Scanning electron microscopy reveals a uniformly distributed layer of spherical SnO2 NPs on the electrode surface; their diameters range from 20 to 40 nm. This modification results in a 3.9-fold increase in the electrode's effective surface area and a 143-fold enhancement in the heterogeneous electron transfer rate constant. It was found that the electrooxidation of taxifolin involves protons. The electrode reaction follows a mixed control mechanism including both diffusion and adsorption components. Under differential pulse voltammetry conditions, using Britton–Robinson buffer of pH 6.0, the sensor detects taxifolin over a concentration range of 0.075 to 25 μM, with a limit of detection of 70.7 nM. These analytical parameters are comparable to those achieved by other electrochemical techniques; however, the proposed method offers greater simplicity and higher speed, and does not require complex electrode modification. The sensor demonstrated successful application to the analysis of dietary supplements containing dihydroquercetin (taxifolin). The results aligned with those obtained by coulometric titration using electrochemically generated bromine.

Keywords

Electrochemical sensors, modified electrodes, voltammetry, phenolic antioxidants, pharmaceutical analysis

The name of the journal

JOURNAL OF ANALYTICAL CHEMISTRY

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-105011693757&doi=10.1134%2fS1061934825700558&partnerID=40&md5=fe00cffea9248a2a2828926500c7cc53

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=316808&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ziyatdinova Guzel Kamilevna	ru_RU
dc.contributor.author	Tarabukina Anna Denisovna	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Ziyatdinova, G.K. A voltammetric sensor based on tin dioxide nanoparticles for the determination of Taxifolin / G.K. Ziyatdinova, A.D. Tarabukina // J. Anal. Chem. - 2025. - V. 80. - � 7. - P. 1264-1273.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=316808&p_lang=2	ru_RU
dc.description.abstract	JOURNAL OF ANALYTICAL CHEMISTRY	ru_RU
dc.description.abstract	A voltammetric sensor for the determination of taxifolin is developed based on a glassy carbon electrode (GCE) modified with tin dioxide nanoparticles (SnO2 NPs) dispersed in N-hexadecylpyridinium bromide. The modification of the electrode surface enhances the reversibility of the electrochemical reaction and significantly increases redox currents compared to an unmodified GCE, by factors of 2.3 and 3.3 for the anodic and cathodic peaks, respectively. Scanning electron microscopy reveals a uniformly distributed layer of spherical SnO2 NPs on the electrode surface; their diameters range from 20 to 40 nm. This modification results in a 3.9-fold increase in the electrode's effective surface area and a 143-fold enhancement in the heterogeneous electron transfer rate constant. It was found that the electrooxidation of taxifolin involves protons. The electrode reaction follows a mixed control mechanism including both diffusion and adsorption components. Under differential pulse voltammetry conditions, using Britton–Robinson buffer of pH 6.0, the sensor detects taxifolin over a concentration range of 0.075 to 25 μM, with a limit of detection of 70.7 nM. These analytical parameters are comparable to those achieved by other electrochemical techniques; however, the proposed method offers greater simplicity and higher speed, and does not require complex electrode modification. The sensor demonstrated successful application to the analysis of dietary supplements containing dihydroquercetin (taxifolin). The results aligned with those obtained by coulometric titration using electrochemically generated bromine.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Electrochemical sensors	ru_RU
dc.subject	modified electrodes	ru_RU
dc.subject	voltammetry	ru_RU
dc.subject	phenolic antioxidants	ru_RU
dc.subject	pharmaceutical analysis	ru_RU
dc.title	A voltammetric sensor based on tin dioxide nanoparticles for the determination of Taxifolin	ru_RU
dc.type	Articles in international journals and collections	ru_RU