KFU. Card publication. Neuroimplants and the Glial Scar: What Makes theBrain

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FEDERAL UNIVERSITY

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NEUROIMPLANTS AND THE GLIAL SCAR: WHAT MAKES THEBRAIN&NDASH;COMPUTER LINK WORK?

Form of presentation

Articles in international journals and collections

Year of publication

2025

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Authors, employees of KFU

Aganov Albert Vartanovich, author

Egorchev Anton Aleksandrovich, author

Melnikova Anastasiya Aleksandrovna, author

Pavelev Mikhail Nikolaevich, author

Other authors

Parpura Vladimir , author

Bibliographic description in the original language

Paveliev, M., Melnikova A., Egorchev A. A., Parpura V., Aganov A.V. “ Neuroimplants and the Glial Scar: What Makes the Brain–Computer Link Work?.” Journal of Neurochemistry 2025, 169, no. 9: e70203. https://doi.org/10.1111/jnc.70203

Annotation

Neuroimplants are likely major technological breakthroughs of the next decade with the potential for unprecedented social im-pact. In addition to attractive and miracle-looking possibilities, the major obstacle for the industry is complicated, unpredictable,and unfavorable side effects due to tissue damage, biocompatibility limitations, and foreign body response at the brain–implantinterface. Luckily, one major barrier preventing the connection of the neuroimplant to brain cells—the glial scar—has been stud-ied previously for its role in brain trauma. This review highlights pharmacological and tissue engineering avenues that could bereadily transferred from the brain trauma area to fast-growing neuroimplant engineering. The opportunities for chondroitinaseABC treatment, stem cells, and hydrogels for the prevention of glial scarring are emphasized. Alternatively, the glial scar mayalso be viewed not as an obstacle but as a possible regeneration-permissive component of the optimally working brain–neuro-implant interface. Feasible steps in that direction are discussed, including applications for chondroitin sulfate-binding peptides.Finally, the crucial role of new microscopy and data processing techniques for peri-implant glial scar monitoring is highlighted.To that end, we stress the importance of artificial intelligence, including artificial neuronal networks, for the analysis of cellmorphology at the brain–neuroimplant interface.

Keywords

brain injury, brain?computer interface, glial scar, microelectrode array, spinal cord injury, stem cells

The name of the journal

Journal of Neurochemistry

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=317095&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Aganov Albert Vartanovich	ru_RU
dc.contributor.author	Egorchev Anton Aleksandrovich	ru_RU
dc.contributor.author	Melnikova Anastasiya Aleksandrovna	ru_RU
dc.contributor.author	Pavelev Mikhail Nikolaevich	ru_RU
dc.contributor.author	Parpura Vladimir	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Paveliev, M., Melnikova A., Egorchev A. A., Parpura V., Aganov A.V. “ Neuroimplants and the Glial Scar: What Makes the Brain–Computer Link Work?.” Journal of Neurochemistry 2025, 169, no. 9: e70203. https://doi.org/10.1111/jnc.70203	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=317095&p_lang=2	ru_RU
dc.description.abstract	Journal of Neurochemistry	ru_RU
dc.description.abstract	Neuroimplants are likely major technological breakthroughs of the next decade with the potential for unprecedented social im-pact. In addition to attractive and miracle-looking possibilities, the major obstacle for the industry is complicated, unpredictable,and unfavorable side effects due to tissue damage, biocompatibility limitations, and foreign body response at the brain–implantinterface. Luckily, one major barrier preventing the connection of the neuroimplant to brain cells—the glial scar—has been stud-ied previously for its role in brain trauma. This review highlights pharmacological and tissue engineering avenues that could bereadily transferred from the brain trauma area to fast-growing neuroimplant engineering. The opportunities for chondroitinaseABC treatment, stem cells, and hydrogels for the prevention of glial scarring are emphasized. Alternatively, the glial scar mayalso be viewed not as an obstacle but as a possible regeneration-permissive component of the optimally working brain–neuro-implant interface. Feasible steps in that direction are discussed, including applications for chondroitin sulfate-binding peptides.Finally, the crucial role of new microscopy and data processing techniques for peri-implant glial scar monitoring is highlighted.To that end, we stress the importance of artificial intelligence, including artificial neuronal networks, for the analysis of cellmorphology at the brain–neuroimplant interface.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	brain injury	ru_RU
dc.subject	brain?computer interface	ru_RU
dc.subject	glial scar	ru_RU
dc.subject	microelectrode array	ru_RU
dc.subject	spinal cord injury	ru_RU
dc.subject	stem cells	ru_RU
dc.title	Neuroimplants and the Glial Scar: What Makes theBrain–Computer Link Work?	ru_RU
dc.type	Articles in international journals and collections	ru_RU